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Central circuit mechanisms underlying infection-induced food intake inhibition

Research Project

Project/Area Number 17K08568
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionNagoya University

Principal Investigator

Nakamura Yoshiko  名古屋大学, 医学系研究科, 講師 (60548543)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsプロスタグランジン / 体温調節 / 恒常性 / 発熱 / 摂食 / 代謝 / 感染 / 脳、神経 / 生体恒常性
Outline of Final Research Achievements

Infection elicits a variety of central symptoms, such as fever, decreased appetite. However, the neural mechanism underlying the infection-induced food intake inhibition is unknown. In this study, I focused on preoptic area neurons that express prostaglandin EP3 receptors, which receive the pyrogenic mediator, prostaglandin E2, produced in response to infections. By using a technique to express reporter genes specifically in EP3 receptor-expressing neurons in the preoptic area, I revealed the brain sites to which EP3 receptor-expressing preoptic neurons project their axons, and also electrophysiologically recorded activities of these neurons. Based on the data obtained from these analyses, I hypothesized that the medullary reticular neurons are involved in the infection-induced suppression of appetite. I am currently testing this hypothesis to further elucidate the central neural circuit mechanisms of infection-induced symptoms.

Academic Significance and Societal Importance of the Research Achievements

プロスタグランジンE2の受容体であるEP3を発現する視床下部の視索前野ニューロンは発熱のスイッチとなることが知られている。しかしながら視索前野のEP3発現ニューロンの神経生理学的特性や、発熱以外の生理反応に関わることは知られていない。本研究によって、視索前野のEP3発現ニューロンが発熱のみならず、その他の感染症状や生理反応にも関わることで生命の維持に重要な役割を果たしていることが示唆された。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2022 2021 2020 2019 2018 2017 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (1 results) Remarks (4 results)

  • [Journal Article] A hypothalamomedullary network for physiological responses to environmental stresses2022

    • Author(s)
      Kazuhiro Nakamura, Yoshiko Nakamura, Naoya Kataoka
    • Journal Title

      Nature Reviews Neuroscience

      Volume: 23 Issue: 1 Pages: 35-52

    • DOI

      10.1038/s41583-021-00532-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 飢餓を生きぬく脳の仕組み2019

    • Author(s)
      中村佳子
    • Journal Title

      自律神経

      Volume: 56 Pages: 257-263

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 飢餓から生命を守るための脳の仕組み2019

    • Author(s)
      中村和弘、中村佳子
    • Journal Title

      脳神経内科

      Volume: 90 Pages: 618-626

    • Related Report
      2019 Research-status Report
  • [Journal Article] Hunger and satiety signaling: Modeling two hypothalamomedullary pathways for energy homeostasis.2018

    • Author(s)
      Kazuhiro Nakamura and Yoshiko Nakamura
    • Journal Title

      BioEssays

      Volume: 40 Issue: 8 Pages: 1700252-1700252

    • DOI

      10.1002/bies.201700252

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation.2017

    • Author(s)
      Takaki Yahiro, Naoya Kataoka, Yoshiko Nakamura & Kazuhiro Nakamura
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 5031-5041

    • DOI

      10.1038/s41598-017-05327-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.2017

    • Author(s)
      Yoshiko Nakamura & Kazuhiro Nakamura
    • Journal Title

      Pfulgers Arch. - Eur. J. Physiol.

      Volume: 印刷中 Issue: 5 Pages: 823-837

    • DOI

      10.1007/s00424-017-2090-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 飢餓反応の中枢神経回路メカニズム.2017

    • Author(s)
      中村和弘、中村佳子
    • Journal Title

      肥満研究

      Volume: 23 Pages: 161-168

    • Related Report
      2017 Research-status Report
  • [Presentation] 飢餓反応中枢神経メカニズム2021

    • Author(s)
      中村佳子 中村和弘
    • Organizer
      大阪大学蛋白質研究所セミナー、食行動の脳内基盤と分子機構
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Glutamatergic and GABAergic populations of prostaglandin EP3 receptor-expressing preoptic neurons are heat-responsive2020

    • Author(s)
      Yoshiko Nakamura
    • Organizer
      第97回日本生理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Prostaglandin EP3 receptor-expressing neurons in the preoptic area are activated by ambient heat exposure2019

    • Author(s)
      Yoshiko Nakamura, Kazuhiro Nakamura
    • Organizer
      Experimental Biology 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Heat exposure of rats activates prostaglandin EP3 receptor-expressing neurons in the preoptic area2018

    • Author(s)
      Yoshiko Nakamura and Kazuhiro Nakamura
    • Organizer
      PPTR2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ニューロペプチドYによる熱産生抑制と摂食亢進の神経メカニズム2018

    • Author(s)
      中村佳子
    • Organizer
      日本自律神経学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 温度知覚と体温調節行動は異なる温度感覚伝達路で駆動される2018

    • Author(s)
      中村和弘、八尋貴樹、片岡直也、中村佳子
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Lateral parabrachial nucleus mediates thermosensory signaling for behavioral thermoregulation2017

    • Author(s)
      Takaki Yahiro, Naoya Kataoka, Yoshiko Nakamura, Kazuhiro Nakamura
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 外側腕傍核を介した神経伝達が駆動する体温調節行動2017

    • Author(s)
      八尋貴樹、片岡直也、中村佳子、中村和弘
    • Organizer
      温熱生理研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Medullary reticular nuclei control metabolism and food intake during starvation2017

    • Author(s)
      Yoshiko Nakamura, Yuchio Yanagawa, Shaun F. Morrison and Kazuhiro Nakamura
    • Organizer
      国際自律神経学会 (ISAN2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ニューロペプチドYによる熱産生抑制と摂食亢進の神経メカニズム2017

    • Author(s)
      中村佳子、中村和弘
    • Organizer
      生命科学系合同年次大会 (ConBio2017)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 行動性体温調節を駆動する外側腕傍核を介した温度上行路の探索2017

    • Author(s)
      八尋貴樹、片岡直也、中村佳子、中村和弘
    • Organizer
      自律神経研究会
    • Related Report
      2017 Research-status Report
  • [Book] 生命誌年刊号「和ーなごむ・やわらぐ・あえる・のどまる」2018

    • Author(s)
      中村桂子編(中村佳子:飢えからからだを守る脳の神経回路)
    • Total Pages
      209
    • Publisher
      新曜社
    • ISBN
      9784788516007
    • Related Report
      2018 Research-status Report
  • [Remarks] 名古屋大学大学院医学系研究科統合生理学

    • URL

      https://www.med.nagoya-u.ac.jp/physiol2/

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
  • [Remarks] 名古屋大学大学院医学研究科統合生理学

    • URL

      https://www.med.nagoya-u.ac.jp/physiol2/

    • Related Report
      2019 Research-status Report
  • [Remarks] 名古屋大学大学院医学研究科統合生理学

    • URL

      https://www.med.nagoya-u.ac.jp/physiol2

    • Related Report
      2018 Research-status Report
  • [Remarks] 名古屋大学大学院医学系研究科統合生理学分野

    • URL

      https://www.med.nagoya-u.ac.jp/physiol2/

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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