| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We have shown that deprivation of social play behavior in adolescent rats leads to impaired social behavior in adult rats. The purpose of this study was to test the hypothesis that this phenomenon is related to plastic dysfunction of oxytocin neural circuits. In this study, we generated genetically modified rats to identify the oxytocin neural circuits activated by social play behavior and manipulate their activities. Since oxytocin receptor-deficient rats showed no abnormalities in social play behavior during adolescence and social behavior after maturation, we are verifying the roles of oxytocin-synthesizing neurons by selective ablation of these neurons.
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