Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
We have reported that vasoactive peptide adrenomedullin (AM) and its receptor activity-modifying protein RAMP2 possess angiogenic function and regulate vascular homeostasis. On the other hand, AM and RAMP2 are highly expressed in various cancers. In this study, using drug-inducible endothelial cell-specific RAMP2 knockout mice (DI-E-RAMP2-/-), we analyzed the significance of AM-RAMP2 system in cancer angiogenesis and metastasis. In tumor implantation model, we found that angiogenesis of primary lesion was suppressed, whereas spontaneous lung metastasis was increased. Vascular integrity regulated by the AM-RAMP2 system could thus be a hopeful therapeutic target for suppressing tumor metastasis.
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