| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
1) Using mDia1/3 DKO mice, we found that mDia1/3 promoted differentiation of nTreg cells. 2) We induced differentiation of iTreg cells in vitro and found that mDia1 / 3 is also essential for iTreg differentiation. 3) When we stimulated TCR signaling that is critical for Treg differntiation, we found that the F-actin structure and kinetics of mDia1/3-deficient T cells were significantly inhibited. 4) For gene expression analysis, we generated mDia1/3 cDKO mice in which Treg cells were fluorescently labeled with EGFP.
|
