Identification of molecules which are released from nerons to induce neuroinflammation
| Project/Area Number |
17K08593
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kobe University |
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Principal Investigator |
Kitaoka Shiho 神戸大学, 医学研究科, 講師 (00545246)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 反復ストレス / 脳内炎症 / ミクログリア / TLR / PGE2 / DREADD / 神経細胞 / DAMPs / 薬理学 |
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| Outline of Final Research Achievements |
Social stress activates microglia through Toll-like receptor in the medial prefrontal cortex. The inflammatory cytokines such as IL-1αand TNFα released from prefrontal microglia are required to induce social avoidance. In the subcortical region, stress produces prostaglandin E2 in a Toll-like receptor dependent manner. In addition, monoacylglycerol lipase, is crucial for stress-induced PGE2 production and social avoidance. These results show that social stress releases different inflammation-related molecules from microglia in the respective brain regions.
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| Academic Significance and Societal Importance of the Research Achievements |
脳内には神経細胞のほか、ミクログリアなどのグリア細胞が存在し、脳機能の維持に関与している。近年、生理条件下で、ミクログリアの遺伝子発現が脳領域間で異なることが報告されているものの、機能的意義については不明な点が多い。本研究成果は、炎症に関わるToll様受容体とプロスタグランジンE2を手掛かりとして、反復ストレスが異なる脳領域のミクログリアで誘導する変化を明らかにし、さらに脳機能変化との関連性を示した点において学術的意義があると考えられる。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice2017
Author(s)
Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawa A, Narumiya S, *Furuyashiki T.
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Journal Title
Mol Psychiatry
Volume: -
Issue: 8
Pages: 1717-1730
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Depressive-like behaviors are regulated by NOX1/NADPH oxidase by redox modification of NMDA receptor 1.2017
Author(s)
Ibi M, Liu J, Arakawa N, Kitaoka S, Kawaji A, Matsuda KI, Iwata K, Matsumoto M, Katsuyama M, Zhu K, Teramukai S, Furuyashiki T, Yabe-Nishimura C.
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Journal Title
J Neurosci
Volume: 37
Issue: 15
Pages: 4200-4212
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Repeated stress induces behavioral changes through inflammation-like response.2019
Author(s)
Shiho Kitaoka, Xiang Nie, Kohei Tanaka, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Yuki Imoto, Eri Segi-Nishida, Shuh Narumiya, Tomoyuki Furuyashiki
Organizer
Japan-UK Neuroscience Symposium
Related Report
Invited
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[Presentation] Repeated stress-induced behavioral changes and inflammation-like responses2019
Author(s)
Shiho Kitaoka, Xiang Nie, Kohei Tanaka, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Yuki Imoto, Eri Segi-Nishida, Shuh Narumiya, Tomoyuki Furuyashiki
Organizer
第92回日本薬理学会年会
Related Report
Invited
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[Presentation] Innate immune molecules mediated microglial activation in the medial prefrontal cortex are critical for repeated stress-induced behavioral changes in mice2018
Author(s)
Shiho Kitaoka, Xiang Nie, Kohei Tanaka, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Yuki Imoto, Eri Segi-Nishida, Shuh Narumiya, Tomoyuki Furuyashiki
Organizer
Young Glia
Related Report
Int'l Joint Research
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[Presentation] Innate immune receptors in microglia in the medial prefrontal cortex are critical for social avoidance induced by repeated social defeat stress in mice.2017
Author(s)
Shiho Kitaoka, Xiang Nie, Kohei Tanaka, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Yabin Lu, Yuki Imoto, Eri Segi-Nishida, Shuh Narumiya, Tomoyuki Furuyashiki
Organizer
第40回日本神経科学大会
Related Report
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