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Basic research of cancer therapy by improving anticancer drug sensitivity through tumor vascular remodeling

Research Project

Project/Area Number 17K08602
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionOsaka City University

Principal Investigator

Tomita Shuhei  大阪市立大学, 大学院医学研究科, 教授 (00263898)

Co-Investigator(Kenkyū-buntansha) 松永 慎司  大阪市立大学, 大学院医学研究科, 講師 (30704910)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords低酸素 / がん微小環境 / 腫瘍血管 / 腫瘍免疫 / PHD阻害剤 / HIF / PHD阻害薬 / 自然免疫 / 癌微小環境 / 癌治療
Outline of Final Research Achievements

The tumor microenvironment (TME) polarizes tumor-infiltrating macrophages toward tumor support. Macrophage-abundant tumors are highly malignant and are the cause of poor prognosis and therapeutic resistance. In this study, we show that the prolyl hydroxylase (PHD) inhibitor FG-4592 (FG) inhibits tumor growth of macrophage-abundant tumors and prolongs mouse survival. FG not only normalizes tumor vessels and improves tumor oxygenation but also directly affects macrophages and activates phagocytosis through the PHD-hypoxia-inducible factor (HIF) axis. Remarkably, FG can promote phagocytic ability of the Ly6Clo subset of tumor-infiltrating macrophages, leading to tumor growth inhibition. Moreover, Ly6Cneg macrophages contributed to blood vessel normalization. Using a malignant tumor mouse model, we characterized macrophage function and subsets. Altogether, our findings suggest that the PHD inhibitor can promote the anti-tumor potential of macrophages to improve cancer therapy.

Academic Significance and Societal Importance of the Research Achievements

研究の成果は、がん微小環境が造り出す腫瘍血管と正常血管の違いを明確化することにより組織再構築の分子基盤の解明に繋がると考えられる。また、PHD-HIFを基軸としたシグナルを介して形質変換した腫瘍内マクロファージがもたらす抗腫瘍効果についても同様に詳細な分子機序を明らかにする契機となる。これら研究遂行は、現在の腫瘍免疫療法では難治性を示すがんに対して、自然免疫の活性化過程を標的とした新しい腫瘍免疫療法を創出する可能性を有しており、新規創薬研究分野にも繋がることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (57 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (39 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 38 results,  Open Access: 30 results,  Acknowledgement Compliant: 4 results) Presentation (14 results) (of which Int'l Joint Research: 7 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] National Instututes of Health(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice2020

    • Author(s)
      Nishide Shunji、Uchida Junji、Matsunaga Shinji、Tokudome Kentaro、Yamaguchi Takehiro、Kabei Kazuya、Moriya Taiki、Miura Katsuyuki、Nakatani Tatsuya、Tomita Shuhei
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 143 Issue: 2 Pages: 122-126

    • DOI

      10.1016/j.jphs.2020.02.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats2020

    • Author(s)
      Shimokawa Takaomi、Yoneda Kozo、Yamagata Masayo、Hayashi Kohei、Tomita Shuhei
    • Journal Title

      European Journal of Pharmacology

      Volume: 871 Pages: 172917-172917

    • DOI

      10.1016/j.ejphar.2020.172917

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of PHD inhibitor on tumor microenvironment and tumor immune response2020

    • Author(s)
      Matsunaga S, Tomita S.
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 155 Issue: 1 Pages: 35-39

    • DOI

      10.1254/fpj.19119

    • NAID

      130007778893

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model2020

    • Author(s)
      Kabei Kazuya、Tateishi Yu、Shiota Masayuki、Osada-Oka Mayuko、Nishide Shunji、Uchida Junji、Nakatani Tatsuya、Matsunaga Shinji、Yamaguchi Takehiro、Tomita Shuhei、Miura Katsuyuki
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 142 Issue: 3 Pages: 93-100

    • DOI

      10.1016/j.jphs.2019.12.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Soluble urokinase-type plasminogen activator receptor represents exercise tolerance and predicts adverse cardiac events in patients with heart failure2020

    • Author(s)
      Ishikawa H, Izumiya Y, Shibata A, Ichikawa Y, Yamaguchi T, Yamaguchi Y, Kitada R, Iwata S, Ehara S, Tomita S, Hanatani A, Yoshiyama M.
    • Journal Title

      Heart Vessels.

      Volume: 35 Issue: 5 Pages: 681-688

    • DOI

      10.1007/s00380-019-01538-3

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019871

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of eribulin on breast cancer microenvironment identified using eribulin-resistant breast cancer cell lines.2020

    • Author(s)
      Goto W, Kashiwagi S, Asano Y, Takada K, Takahashi K, Fujita H, Takashima T, Shibutani M, Amano R, Tomita S, Hirakawa K, Ohira M.
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 8 Pages: 4031-4041

    • DOI

      10.21873/anticanres.13559

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model2019

    • Author(s)
      Nishide Shunji、Matsunaga Shinji、Shiota Masayuki、Yamaguchi Takehiro、Kitajima Shojiro、Maekawa Yoichi、Takeda Norihiko、Tomura Michio、Uchida Junji、Miura Katsuyuki、Nakatani Tatsuya、Tomita Shuhei
    • Journal Title

      iScience

      Volume: 21 Pages: 205-205

    • DOI

      10.1016/j.isci.2019.10.031

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical verification of dynamic monitoring of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in primary endocrine therapy for advanced breast cancer2019

    • Author(s)
      Takada K, Kashiwagi S, Asano Y, Goto W, Takahashi K, Shibutani M, Amano R, Takashima T, Tomita S, Hirakawa K, Ohira M.
    • Journal Title

      Anticancer Res

      Volume: 39 Issue: 10 Pages: 55815588-55815588

    • DOI

      10.21873/anticanres.13752

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improving the safety of high-concentration potassium chloride injection.2019

    • Author(s)
      Nakatani K, Nakagami-Yamaguchi E, Shinoda Y, Tomita S, Nakatani T.
    • Journal Title

      BMJ Open Qual.

      Volume: 8 Issue: 2 Pages: e000666-e000666

    • DOI

      10.1136/bmjoq-2019-000666

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Verification of the effects of calcium channel blockers on the immune microenvironment of breast cancer.2019

    • Author(s)
      Takada K, Kashiwagi S, Asano Y, Goto W, Takahashi K, Fujita H, Takashima T, Tomita S, Hirakawa K, Ohira M.
    • Journal Title

      BMC Cancer

      Volume: 19 Issue: 1 Pages: 615-615

    • DOI

      10.1186/s12885-019-5828-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic value of quality of life in endocrine therapy for elderly patients with breast cancer: a retrospective study2019

    • Author(s)
      Takada K, Kashiwagi S, Asano Y, Goto W, Takahashi K, Shibutani M, Amano R, Takashima T, Tomita S, Hirakawa K, Ohira M
    • Journal Title

      Anticancer Res

      Volume: 39 Issue: 6 Pages: 29412950-29412950

    • DOI

      10.21873/anticanres.13424

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical outcomes of recombinant human-soluble thrombomodulin treatment for disseminated intravascular coagulation in solid Tumors.2019

    • Author(s)
      Kashiwagi S, Asano Y, Takahashi K, Shibutani M, Amano R, Tomita S, Hirakawa K, Ohira M.
    • Journal Title

      Anticancer research

      Volume: 39 Issue: 5 Pages: 2259-2264

    • DOI

      10.21873/anticanres.13342

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates cardiac dysfunction after myocardial infarction independently of DPP-42019

    • Author(s)
      Yamaguchi Takehiro、Watanabe Ayano、Tanaka Masako、Shiota Masayuki、Osada-Oka Mayuko、Sano Soichi、Yoshiyama Minoru、Miura Katsuyuki、Kitajima Shojiro、Matsunaga Shinji、Tomita Shuhei、Iwao Hiroshi、Izumi Yasukatsu
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 139 Issue: 2 Pages: 112-119

    • DOI

      10.1016/j.jphs.2018.12.004

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical verification of the relationship between smoking and the immune microenvironment of breast cancer2019

    • Author(s)
      Takada Koji、Kashiwagi Shinichiro、Asano Yuka、Goto Wataru、Takahashi Katsuyuki、Fujita Hisakazu、Takashima Tsutomu、Tomita Shuhei、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      Journal of Translational Medicine

      Volume: 17 Issue: 1 Pages: 13-13

    • DOI

      10.1186/s12967-019-1773-y

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possibility of avoiding axillary lymph node dissection by immune microenvironment monitoring in preoperative chemotherapy for breast cancer2018

    • Author(s)
      Takada Koji、Kashiwagi Shinichiro、Goto Wataru、Asano Yuka、Takahashi Katsuyuki、Fujita Hisakazu、Takashima Tsutomu、Tomita Shuhei、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      Journal of Translational Medicine

      Volume: 16 Issue: 1 Pages: 318-318

    • DOI

      10.1186/s12967-018-1692-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive value of lymphocyte-to-monocyte ratio in the preoperative setting for progression of patients with breast cancer2018

    • Author(s)
      Goto Wataru、Kashiwagi Shinichiro、Asano Yuka、Takada Koji、Takahashi Katsuyuki、Hatano Takaharu、Takashima Tsutomu、Tomita Shuhei、Motomura Hisashi、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 1137-1137

    • DOI

      10.1186/s12885-018-5051-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy2018

    • Author(s)
      Goto Wataru、Kashiwagi Shinichiro、Takada Koji、Asano Yuka、Takahashi Katsuyuki、Fujita Hisakazu、Takashima Tsutomu、Tomita Shuhei、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      Journal of Translational Medicine

      Volume: 16 Issue: 1 Pages: 307-307

    • DOI

      10.1186/s12967-018-1679-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive value of improvement in the immune tumour microenvironment in patients with breast cancer treated with neoadjuvant chemotherapy2018

    • Author(s)
      Goto Wataru、Kashiwagi Shinichiro、Asano Yuka、Takada Koji、Takahashi Katsuyuki、Hatano Takaharu、Takashima Tsutomu、Tomita Shuhei、Motomura Hisashi、Ohsawa Masahiko、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      ESMO Open

      Volume: 3 Issue: 6 Pages: e000305-e000305

    • DOI

      10.1136/esmoopen-2017-000305

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of re-biopsy for recurrent breast cancer in the immune tumour microenvironment2018

    • Author(s)
      Takada Koji、Kashiwagi Shinichiro、Goto Wataru、Asano Yuka、Takahashi Katsuyuki、Hatano Takaharu、Takashima Tsutomu、Tomita Shuhei、Motomura Hisashi、Ohsawa Masahiko、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      British Journal of Cancer

      Volume: 119 Issue: 5 Pages: 572-579

    • DOI

      10.1038/s41416-018-0197-4

    • NAID

      120006548611

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019691

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel evaluation scale for QOL (QOL-ACD-BP) in preoperative chemotherapy for breast cancer2018

    • Author(s)
      Takada Koji、Kashiwagi Shinichiro、Goto Wataru、Asano Yuka、Takahashi Katsuyuki、Morisaki Tamami、Takashima Tsutomu、Tomita Shuhei、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 144 Issue: 8 Pages: 1547-1559

    • DOI

      10.1007/s00432-018-2670-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells2018

    • Author(s)
      Kitajima Shojiro、Lee Kian Leong、Fujioka Masaki、Sun Wendi、You Jia、Chia Grace Sushin、Wanibuchi Hideki、Tomita Shuhei、Araki Marito、Kato Hiroyuki、Poellinger Lorenz
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 27 Pages: 19123-19135

    • DOI

      10.18632/oncotarget.24919

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Significance of the Neutrophil?to?Lymphocyte Ratio in Endocrine Therapy for Stage IV Breast Cancer2018

    • Author(s)
      Iimori N, Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Hatano T, Takashima T, Tomita S, Motomura H, Hirakawa K, Ohira M.
    • Journal Title

      In Vivo

      Volume: 32 Issue: 3

    • DOI

      10.21873/invivo.11292

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Use of the tumor-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to combination therapy with pertuzumab, trastuzumab, and docetaxel for advanced HER2-positive breast cancer2018

    • Author(s)
      Takada Koji、Kashiwagi Shinichiro、Goto Wataru、Asano Yuka、Takahashi Katsuyuki、Takashima Tsutomu、Tomita Shuhei、Ohsawa Masahiko、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      Journal of Translational Medicine

      Volume: 16 Issue: 1 Pages: 86-86

    • DOI

      10.1186/s12967-018-1460-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of the treatment response to pre-operative chemotherapy in breast cancer by the checkpoint protein expression2018

    • Author(s)
      Asano Y, Kashiwagi S, Goto W, Takada K, Takahashi K, Morisaki T, Fujita H, Takashima T, Tomita S, Ohsawa M, Hirakawa K, Ohira M.
    • Journal Title

      Journal of translational Medicine

      Volume: 16 Issue: 1 Pages: 87-87

    • DOI

      10.1186/s12967-018-1458-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prediction of Treatment Response to Neoadjuvant Chemotherapy in Breast Cancer by Subtype Using Tumor-infiltrating Lymphocytes2018

    • Author(s)
      Asano Y, Kashiwagi S, Goto W, Takada K, Takahashi K, Hatano T, Takashima T, Tomita S, Motomura H, Ohsawa M, Hirakawa K, Ohira M.
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 4 Pages: 2311-2321

    • DOI

      10.21873/anticanres.12476

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study on the progression types of cancer in patients with breast cancer undergoing eribulin chemotherapy and tumor microenvironment2018

    • Author(s)
      Kashiwagi S, Tsujio G, Asano Y, Goto W, Takada K, Takahashi K, Morisaki T, Fujita H, Takashima T, Tomita S, Ohsawa M, Hirakawa K, Ohira M.
    • Journal Title

      Journal of translational Medicine

      Volume: 16 Issue: 1 Pages: 54-54

    • DOI

      10.1186/s12967-018-1443-5

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules2018

    • Author(s)
      Kabei Kazuya、Tateishi Yu、Nozaki Masakazu、Tanaka Masako、Shiota Masayuki、Osada-Oka Mayuko、Nishide Shunji、Uchida Junji、Nakatani Tatsuya、Tomita Shuhei、Miura Katsuyuki
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 136 Issue: 1 Pages: 31-38

    • DOI

      10.1016/j.jphs.2017.12.004

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mesenchymal?epithelial Transition and Tumor Vascular Remodeling in Eribulin Chemotherapy for Breast Cancer2018

    • Author(s)
      Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Hatano T, Tanaka S, Takashima T, Tomita S, Motomura H, Ohsawa M, Hirakawa K, Ohira M.
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 1 Pages: 401-410

    • DOI

      10.21873/anticanres.12236

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Red ginseng extracts attenuate skin inflammation in atopic dermatitis through p70 ribosomal protein S6 kinase activation2018

    • Author(s)
      Osada-Oka Mayuko、Hirai Sayaka、Izumi Yasukatsu、Misumi Kazuhiro、Samukawa Keiichi、Tomita Shuhei、Miura Katsuyuki、Minamiyama Yukiko、Iwao Hiroshi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 136 Issue: 1 Pages: 9-15

    • DOI

      10.1016/j.jphs.2017.11.002

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal-epithelial Transition and Tumor Vascular Remodeling in Eribulin Chemotherapy for Breast Cancer.2018

    • Author(s)
      Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Hatano T, Tanaka S, Takashima T, Tomita S, Motomura H, Ohsawa M, Hirakawa K, Ohira M
    • Journal Title

      Anticancer Res

      Volume: 38 Pages: 401-410

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of hypoxia inducible factor-1α in the temporomandibular joint2017

    • Author(s)
      Mino-Oka A, Izawa T, Shinohara T, Mori H, Yasue A, Tomita S, Tanaka E
    • Journal Title

      Archives of Oral Biology

      Volume: 73(1) Pages: 274-281

    • DOI

      10.1016/j.archoralbio.2016.10.028

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice.2017

    • Author(s)
      Islam J, Sato S, Watanabe K, Watanabe T, Ardiansyah, Hirahara K, Aoyama Y, Tomita S, Aso H, Komai M, Shirakawa H
    • Journal Title

      J Nutr Biochem

      Volume: 42 Pages: 43-50

    • DOI

      10.1016/j.jnutbio.2016.12.019

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Use of tumor-infiltrating lymphocytes (TILs) to predict the treatment response to eribulin chemotherapy in breast cancer.2017

    • Author(s)
      Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Noda S, Takashima T, Onoda N, Tomita S, Ohsawa M, Hirakawa K, Ohira M.
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 2 Pages: e0170634-e0170634

    • DOI

      10.1371/journal.pone.0170634

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model.2017

    • Author(s)
      Koyama S, Matsunaga S, Imanishi M, Maekawa Y, Kitano H, Takeuchi H, Tomita S
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 45621-45621

    • DOI

      10.1038/srep45621

    • NAID

      120006535012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reoxygenation with 100% Oxygen Following Hypoxia in Mice Causes Apoptosis.2017

    • Author(s)
      Nishimura Y, Ueki M, Imanishi M, Tomita S, Ueno M, Morishita J, Nishiyama T.
    • Journal Title

      Shock

      Volume: 48 Issue: 5 Pages: 590-594

    • DOI

      10.1097/shk.0000000000000891

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circulating tumor cell clusters-associated gene plakoglobin is a significant prognostic predictor in patients with breast cancer2017

    • Author(s)
      Goto Wataru、Kashiwagi Shinichiro、Asano Yuka、Takada Koji、Takahashi Katsuyuki、Hatano Takaharu、Takashima Tsutomu、Tomita Shuhei、Motomura Hisashi、Ohsawa Masahiko、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      Biomark Res

      Volume: 5 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s40364-017-0099-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells2017

    • Author(s)
      Kita Kazuaki、Shiota Masayuki、Tanaka Masako、Otsuka Asuka、Matsumoto Masaki、Kato Minoru、Tamada Satoshi、Iwao Hiroshi、Miura Katsuyuki、Nakatani Tatsuya、Tomita Shuhei
    • Journal Title

      Cancer Sci

      Volume: 108 Issue: 9 Pages: 1820-1827

    • DOI

      10.1111/cas.13318

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Using TILs to Predict Therapeutic Effect of Chemotherapy (Pertuzumab, Trastuzumab, Docetaxel) on HER2-positive Breast Cancer.2017

    • Author(s)
      Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Hatano T, Takashima T, Tomita S, Motomura H, Ohsawa M, Hirakawa K, Ohira M
    • Journal Title

      Anticancer Res

      Volume: 37 Pages: 5623-5630

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prediction of survival after neoadjuvant chemotherapy for breast cancer by evaluation of tumor-infiltrating lymphocytes and residual cancer burden2017

    • Author(s)
      Asano Yuka、Kashiwagi Shinichiro、Goto Wataru、Takada Koji、Takahashi Katsuyuki、Hatano Takaharu、Noda Satoru、Takashima Tsutomu、Onoda Naoyoshi、Tomita Shuhei、Motomura Hisashi、Ohsawa Masahiko、Hirakawa Kosei、Ohira Masaichi
    • Journal Title

      BMC Cancer

      Volume: 17 Issue: 1 Pages: 888-888

    • DOI

      10.1186/s12885-017-3927-8

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Alteration the phenotype of tumor-infiltrating macrophages via the PHD-HIF axis inhibits tumor growth in mice.2020

    • Author(s)
      Shunji Nishide, Shinji Matsunaga, Takehiro Yamaguchi, Norihiko Takeda, Junji Uchida, Katsuyuki Miura, Tatsuya Nakatani and Shuhei Tomita
    • Organizer
      Keystone Symposia -Hypoxia: Molecules, Mechanisms and Disease-
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PHD阻害剤による腫瘍浸潤マクロファージの表現型変化は腫瘍環境改善を誘導する2020

    • Author(s)
      松永 慎司、西出 峻治、徳留 健太郎、山口 雄大、冨田 修平
    • Organizer
      第93回日本薬理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胎児期低酸素ストレス負荷による自閉症様症状の発現には抑制性シナプス関連遺伝子の発現低下が関与する2020

    • Author(s)
      徳留 健太郎、松永 慎司、山口 雄大、冨田 修平
    • Organizer
      第93回日本薬理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リナグリプチンは心筋梗塞後のDPP-4非依存的に左室リモデリングを抑制する2020

    • Author(s)
      山口 雄大、泉 康雄、塩田 正之、松永 慎司、德留 健太郎、三浦 克之、岩尾 洋、冨田 修平
    • Organizer
      第93回日本薬理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リポポリサッカライド誘発性腎障害に対するヨヒンビンの効果2020

    • Author(s)
      下川 隆臣、山形 雅代、林 耕平、冨田 修平、米田 耕造
    • Organizer
      第93回日本薬理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肺血管内皮細胞由来低酸素応答因子 HIF が肺高血圧症の 病態形成に果たす役割2018

    • Author(s)
      冨田修平,山口雄大,松永慎司
    • Organizer
      第47回日本心脈管作動物質学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] The role of HIF-1 in the development of renal fibrosis with special reference to HIF-1 dependent gene expression.2018

    • Author(s)
      Kabei K., Nozaki M., Uchida J., Nakatani T., Tomita S. and Miura K
    • Organizer
      ISN Frontiers 2018, Feb.22-25, Tokyo
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prolyl Hydroxylase inhibitor repaired chemo-sensitivity through tumor blood vessel normalization in tumor mouse model.2018

    • Author(s)
      Shinji Matsunaga, Shunji Nishide, Masayuki Shiota, Takehiro Yamaghchi, Shojiro Kitajima, Katsuyuki Miura and Shuhei Tomita.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology, July 1-6, Kyoto
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dipeptidyl Peptidase-4 (DPP-4) inhibition Attenuates Cardiac Dysfunction after Myocardial Infarction Independently of DPP-4.2018

    • Author(s)
      Yamaguchi T, Izumi Y, Shiota M, Tanaka M, Osada-Oka M, Matsunaga S, Kitajima S, Miura K, Iwao H, Tomita S
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology, July 1-6, Kyoto
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hypoxia-inducible factor-1α regulates energy fuel metabolism and mediates metabolic plasticity during ammonia stress response in ovarian cancer stem-like cells.2018

    • Author(s)
      Shojiro Kitajima, Kian Leong Lee, Hiroki Hikasa, Shinji Matsunaga, Takehiro Yamaguchi, Shuhei Tomita, Marito Araki, Hiroyuki Kato and Lorenz Poellinger
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology, July 1-6, Kyoto
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The role of HIF-1 in the development of renal fibrosis in mouse UUO model with special reference to HIF-1 dependent gene expression.2018

    • Author(s)
      Kabei K., Osada-Oka M.,Nozaki M., Shiota M., Tanaka M., Tomita S. and Miura K.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology, July 1-6, Kyoto
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The new role of HIF-1 in the development of renal fibrosis in mouse UUO model.2018

    • Author(s)
      Kabei K., Uchida J., Tateishi Y., Nishide S., Kosoku A., Iwai T., Kuwabara N., Nakatani T. and Miura K.
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology, July 1-6, Kyoto
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血管リモデリングにおける平滑筋由来HIF-1αの役割2017

    • Author(s)
      冨田修平
    • Organizer
      第46回日本心脈管作動物質学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Role of hypoxia inducible factor-1 in Vascular Remodeling2017

    • Author(s)
      Shuhei Tomita
    • Organizer
      第94回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Book] カラー 新しい薬理学2018

    • Author(s)
      石井邦明、西山 成
    • Total Pages
      588
    • Publisher
      西村書店
    • ISBN
      9784890134854
    • Related Report
      2018 Research-status Report
  • [Remarks]

    • URL

      http://www.med.osaka-cu.ac.jp/departments/bunshi-pharmacology.shtml

    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 腫瘍関連マクロファージ賦活化剤2019

    • Inventor(s)
      冨田修平・松永慎司・西出峻治・内田潤次
    • Industrial Property Rights Holder
      冨田修平・松永慎司・西出峻治・内田潤次
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-143014
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-12-27  

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