| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We investigated the role of microsomal prostaglandin E synthase-1 (mPGES-1) in demyelination and motor dysfunction induced by cuprizone, one of the well-established models of multiple sclerosis (MS). Demyelination in the brain was induced in mPGES-1 knock-out (KO) and wild-type (WT) mice by feeding ad libitum with a powdered diet containing cuprizone. Cuprizone up-regulated the expression of mPGES-1 in the brain of WT mice. Interestingly, mPGES-1 KO mice exhibited lower degree of demyelination and reduced motor dysfunction compared to WT mice. These data indicate that mPGES-1 and its derived prostaglandin E2 (PGE2) might contribute to the pathophysiology of MS and open possible novel therapeutic approaches for MS.
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