| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We recorded the spontaneous automaticity from the myocardial layer of isolated pulmonary veins with high-speed 3-dimensional confocal microscopy and glass microelectrode technique. Spontaneous automaticity was observed in isolated pulmonary vein preparations and firing frequency was enhanced by angiotensinⅡ, while reduced by losartan, AT1 receptor blocker. AngiotensinⅡ affected the diastolic depolarization slope and induced local calcium oscillations followed by spontaneous automaticity. These results indicated that spontaneous automaticity of the pulmonary vein myocardium is influenced by the renin-angiotensin system.
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