| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We conducted an analysis focusing on weaver mutant mice that have a gene mutation in the G protein-activated inwardly-rectifying potassium channel (GIRK channel), and revealed that methamphetamine-induced reward was partially observed in heterozygous mutant mice and completely abolished in homozygous mutant mice. Furthermore, weaver mutant mice have enhanced methamphetamine-induced dopamine release in the nucleus accumbens, but its level is significantly reduced in wild-type mice. It was also revealed that the methamphetamine-induced neuronal activation was disappeared in the posterior shell region of the nucleus accumbens in weaver mutant mice.
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