| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this research project, we attempted to clarify the role of Mer tyrosine kinase (Mer) in the novel oncogenic signal, Ras/IL-33 pathway. In the previous study, we concluded that Ras accelerates the expression of Mer in depending on IL-33. We found that IL-33 and Mer were required for Ras-induced cellular migration. Ras signal promoted the phosphorylation of Mer and the kinase activity of Mer was necessary for Ras-induced cellular migration. Taken together, it is suggested that Ras/IL-33 pathway contributes the cancer malignant progression via Mer tyrosine kinase.
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