The novel oncogenic signal with tyrosine phosphorylation induced by Ras
| Project/Area Number |
17K08641
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
Ohta Satoshi 自治医科大学, 医学部, 講師 (40528428)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | Ras / Mer / IL-33 / がんの悪性化 / がん / 発がんシグナル / Merチロシンキナーゼ / シグナル伝達 |
|---|
| Outline of Final Research Achievements |
In this research project, we attempted to clarify the role of Mer tyrosine kinase (Mer) in the novel oncogenic signal, Ras/IL-33 pathway. In the previous study, we concluded that Ras accelerates the expression of Mer in depending on IL-33. We found that IL-33 and Mer were required for Ras-induced cellular migration. Ras signal promoted the phosphorylation of Mer and the kinase activity of Mer was necessary for Ras-induced cellular migration. Taken together, it is suggested that Ras/IL-33 pathway contributes the cancer malignant progression via Mer tyrosine kinase.
|
| Academic Significance and Societal Importance of the Research Achievements |
Ras遺伝子の変異によるRasシグナルの異常な活性化は、多くのがんの原因となることが知られており、特に難治性がんの一つである膵がんでは約90%の患者でRas遺伝子の変異が見つかっている。Rasの下流シグナルに関してもMAPキナーゼをはじめとして多くの知見が集積している一方で、MAPキナーゼ経路を標的とした抗がん剤治療には、耐性を示す患者も多く存在する。本研究によって新規Rasシグナルの構成因子とその機能が明らかなることは、今後の抗がん剤開発において重要な基盤となると期待される。
|
Report
(4 results)
Research Products
(10 results)
-
[Journal Article] Oncogenic Ras mutant causes thehyper-activation of NF-kB via acceleration of its transcriptional activation.2019
Author(s)
(10)Tago K, Funakoshi-Tago M, Ohta S, Kawata H, Saitoh H, Horie H, Aoki-Ohmura C, Yamauchi J, Tanaka A, Matsugi J, Yanagisawa K.
-
Journal Title
Mol Oncol.
Volume: 13(11)
Pages: 2493-2510
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
