| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
By analyzing the skeletal muscle tissue of the knockout mouse of protein methyltransferase Mettl21e, I revealed that Mettl21e is a novel regulator of skeletal muscle mass. I also identified a skeletal muscle protein as a substrate for Mettl21e and found that Mettl21e regulates skeletal muscle mass through the methylation of muscle protein. Although the use of Mettl21e to increase the size of human skeletal muscle cells has not yet been successful due to the issue of gene transfer efficiency, it was suggested that Mettl21e could be applied to new treatments for human muscle atrophy by improving the method.
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