Development of a new treatment for skeletal muscle atrophy by targeting human pseudogene
| Project/Area Number |
17K08646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Fujita Health University |
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Principal Investigator |
Hitachi Keisuke 藤田医科大学, 総合医科学研究所, 助教 (10508469)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | タンパク質メチル化修飾 / 骨格筋 / 筋萎縮 / 筋肥大 / メチル化酵素 / タンパク質メチル化酵素 / 翻訳後修飾 / 質量分析 / 筋疾患 / 偽遺伝子 |
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| Outline of Final Research Achievements |
By analyzing the skeletal muscle tissue of the knockout mouse of protein methyltransferase Mettl21e, I revealed that Mettl21e is a novel regulator of skeletal muscle mass. I also identified a skeletal muscle protein as a substrate for Mettl21e and found that Mettl21e regulates skeletal muscle mass through the methylation of muscle protein. Although the use of Mettl21e to increase the size of human skeletal muscle cells has not yet been successful due to the issue of gene transfer efficiency, it was suggested that Mettl21e could be applied to new treatments for human muscle atrophy by improving the method.
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| Academic Significance and Societal Importance of the Research Achievements |
疾患や老化によって引き起こされる骨格筋の量の減少（筋萎縮）は、疾患での生存率やQOL（クオリティ・オブ・ライフ）を低下させるだけでなく、社会的な生産性の低下にもつながる。しかしながら、筋萎縮に対する安全で有効な治療薬は未だ存在しない。本研究により、骨格筋量の制御とタンパク質のメチル化修飾の意義が明らかとなったことで、将来的には特定のタンパク質のメチル化修飾を標的とした筋萎縮に対する新たな創薬が可能になると考えられる。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] UBL3 modification influences protein sorting to small extracellular vesicles.2018
Author(s)
Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
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Journal Title
Nature Communications
Volume: 9
Issue: 1
Pages: 3936-3936
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Multiplicity in Long Noncoding RNA Biomedical Sciences2018
Author(s)
3.R. Kurokawa, R. Komiya, T. Oyoshi, Y. Matsuno, H. Tani, M. Katahira, K. Hitachi, Y. Iwashita, T. Yamashita, K. Kondo, R. Yoneda, Y. Yamaoki, N. Ueda, T. Mashima, N. Kobayashi, T. Nagata, A. Kiyoishi, M. Miyake, F. Kano, M. Murata1, N. Hamad, K. Sasaki, N. Shoji
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Journal Title
Biomedical Sciences
Volume: 4
Issue: 2
Pages: 18-23
DOI
Related Report
Peer Reviewed / Open Access
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