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Roel of extracellular NAD against malaria infection

Research Project

Project/Area Number 17K08653
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathological medical chemistry
Research InstitutionUniversity of Toyama

Principal Investigator

Nakagawa Takashi  富山大学, 学術研究部医学系, 教授 (40610374)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsマラリア / NAD代謝 / NAD
Outline of Final Research Achievements

In this research project, we elucidate how the extracellular NAD signal is involved in the defense against malaria infection. We hypothesised that NAD released from red blood cells at the early stage of malaria infection acts as an extracellular signal to prevent malaria infection. We revealed that the Preiss-handler pathway was activated by malaria infection. It was also found that NAD acts extracellularly on macrophages and promoted to releases various inflammatory cytokines. However, it was suggested that TLR4 was not involved in the macrophage activation and that there is an altenative pathway.

Academic Significance and Societal Importance of the Research Achievements

マラリアは現在においても年間2億人の人々が感染し、発展途上国を中心として100万人の死者を出す原虫感染症である。そのため、より効果的な治療薬の開発が望まれている。本研究は、マラリア感染においてNAD代謝が関与していることの一端を明らかにした研究であり、NAD代謝がマラリア治療の新たなターゲットとなることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (21 results)

All 2020 2019 2018 2017 Other

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 11 results) Presentation (3 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity2020

    • Author(s)
      Fujisaka Shiho、Usui Isao、Nawaz Allah、Igarashi Yoshiko、Okabe Keisuke、Furusawa Yukihiro、Watanabe Shiro、Yamamoto Seiji、Sasahara Masakiyo、Watanabe Yoshiyuki、Nagai Yoshinori、Yagi Kunimasa、Nakagawa Takashi、Tobe Kazuyuki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5544-5544

    • DOI

      10.1038/s41598-020-62506-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway2020

    • Author(s)
      Nishida Yasuhiro、Nawaz Allah、Kado Tomonobu、Takikawa Akiko、Igarashi Yoshiko、Onogi Yasuhiro、Wada Tsutomu、Sasaoka Toshiyasu、Yamamoto Seiji、Sasahara Masakiyo、Imura Johji、Tokuyama Kumpei、Usui Isao、Nakagawa Takashi、Fujisaka Shiho、Kunimasa Yagi、Tobe Kazuyuki
    • Journal Title

      Journal of Cachexia, Sarcopenia and Muscle

      Volume: 11 Issue: 1 Pages: 241-258

    • DOI

      10.1002/jcsm.12530

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity.2020

    • Author(s)
      Yasukawa K, Kinoshita D, Yaku K, Nakagawa T, Koshiba T.
    • Journal Title

      J Biol Chem.

      Volume: 295(2) Issue: 2 Pages: 444-457

    • DOI

      10.1074/jbc.ra119.010511

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD).2019

    • Author(s)
      Yaku K, Okabe K, Gulshan M, Takatsu K, Okamoto H, Nakagawa T.
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 13102-13102

    • DOI

      10.1038/s41598-019-49547-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases.2019

    • Author(s)
      Hikosaka K, Yaku K, Okabe K, Nakagawa T.
    • Journal Title

      Nutr Neurosci.

      Volume: - Issue: 5 Pages: 1-17

    • DOI

      10.1080/1028415x.2019.1637504

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implications of altered NAD metabolism in metabolic disorders.2019

    • Author(s)
      Okabe K, Yaku K, Tobe K, Nakagawa T.
    • Journal Title

      J Biomed Sci.

      Volume: 26(1) Issue: 1 Pages: 34-34

    • DOI

      10.1186/s12929-019-0527-8

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] NAD代謝 による老化・疾患制御2019

    • Author(s)
      中川崇
    • Journal Title

      臨床化学

      Volume: 48 Pages: 22-27

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice2018

    • Author(s)
      Nawaz Allah、Mehmood Arshad、Kanatani Yukiko、Kado Tomonobu、Igarashi Yoshiko、Takikawa Akiko、Yamamoto Seiji、Okabe Keisuke、Nakagawa Takashi、Yagi Kunimasa、Fujisaka Shiho、Tobe Kazuyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 11370-11370

    • DOI

      10.1038/s41598-018-29773-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance2018

    • Author(s)
      Gulshan Maryam、Yaku Keisuke、Okabe Keisuke、Mahmood Arshad、Sasaki Tsutomu、Yamamoto Masashi、Hikosaka Keisuke、Usui Isao、Kitamura Tadahiro、Tobe Kazuyuki、Nakagawa Takashi
    • Journal Title

      Aging Cell

      Volume: 17 Issue: 4

    • DOI

      10.1111/acel.12798

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice2018

    • Author(s)
      Matsui Sho、Sasaki Tsutomu、Kohno Daisuke、Yaku Keisuke、Inutsuka Ayumu、Yokota-Hashimoto Hiromi、Kikuchi Osamu、Suga Takayoshi、Kobayashi Masaki、Yamanaka Akihiro、Harada Akihiro、Nakagawa Takashi、Onaka Tatsushi、Kitamura Tadahiro
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1-17

    • DOI

      10.1038/s41467-018-07033-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] NAD metabolism: Implications in aging and longevity2018

    • Author(s)
      Yaku Keisuke、Okabe Keisuke、Nakagawa Takashi
    • Journal Title

      Ageing Research Reviews

      Volume: 47 Pages: 1-17

    • DOI

      10.1016/j.arr.2018.05.006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] NAD Metabolism in Cancer Therapeutics2018

    • Author(s)
      Yaku Keisuke、Okabe Keisuke、Hikosaka Keisuke、Nakagawa Takashi
    • Journal Title

      Frontiers in Oncology

      Volume: 8 Pages: 622-622

    • DOI

      10.3389/fonc.2018.00622

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice2018

    • Author(s)
      Okabe Keisuke、Usui Isao、Yaku Keisuke、Hirabayashi Yoshio、Tobe Kazuyuki、Nakagawa Takashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 504 Issue: 1 Pages: 309-314

    • DOI

      10.1016/j.bbrc.2018.08.180

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem-mass spectrometry2018

    • Author(s)
      Yaku K、Okabe K、Nakagawa T
    • Journal Title

      Biomedical Chromatography

      Volume: 32 Issue: 6 Pages: 1-11

    • DOI

      10.1002/bmc.4205

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors2017

    • Author(s)
      Nawaz Allah, , Usui Isao, , et al
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 286-301

    • DOI

      10.1038/s41467-017-00231-1

    • NAID

      120006535075

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting metabolic pathways for head and neck cancers therapeutics2017

    • Author(s)
      Yamamoto M、Inohara H、Nakagawa T
    • Journal Title

      Cancer and Metastasis Reviews

      Volume: 36 Issue: 3 Pages: 503-514

    • DOI

      10.1007/s10555-017-9691-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] NAD 代謝による老化制御機構2017

    • Author(s)
      夜久圭介、中川崇
    • Journal Title

      基礎老化研究

      Volume: 41 Pages: 23-27

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 新規NAD代謝経路の解析2019

    • Author(s)
      中川崇, 夜久圭介
    • Organizer
      日本ビタミン学会第71回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マラリア感染時の免疫応答におけるNADの役割2017

    • Author(s)
      夜久圭介,中川崇
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] NAD代謝の疾患生物学2017

    • Author(s)
      中川崇
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Remarks] 富山大学医学部分子医科薬理学講座ホームページ

    • URL

      http://www.med.u-toyama.ac.jp/pharma/index.html

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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