| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Leukotriene B4 (LTB4) is produced from arachidonic acid by leukotriene A4 hydrolase (LTA4H). LTA4H adds water molecule on LTA4 to generate LTB4 and also degrades proteins by using its aminopeptidase activity. LTA4H thus uses lipid and protein as substrates. In the present study, I generated LTA4H knockout mice and analyzed the biological significance of LTA4H in vivo. I found that contact dermatitis was ameliorated and obesity was improved in LTA4H deficient mice. The former is dependent on the LTB4 producing activity of LTA4H, but the latter is independent on the activity. In addition, I identified novel lipid mediator namely RvEx produced by LTA4H.These results suggested the biological significance of LTA4H in inflammation and obesity.
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