| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, we have demonstrated for the first time that a newly identified liver-derived factor, neuregulin 1, is induced in liver of diabetic mice with increased its protein levels in blood. In diabetic conditions, loss of hepatic neuregulin 1 aggravates glucose tolerance while administration of neuregulin 1 protein ameliorates it. These results strongly suggest that neuregulin 1 serves as a defensive mechanism against type 2 diabetes and could be a novel therapeutic target for type 2 diabetes.
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