| Project/Area Number |
17K08692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Kshima Ryoji 滋賀医科大学, 医学部, 教授 (40252382)
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| Co-Investigator(Kenkyū-buntansha) |
福田 昌英 大分大学, 医学部, 医員 (80854299)
向所 賢一 滋賀医科大学, 医学部, 准教授 (50343223)
松原 亜季子 滋賀医科大学, 医学部, 助教 (80626325)
石垣 宏仁 滋賀医科大学, 医学部, 助教 (90432301)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | fundic gland polyps / foveolar cell / parietal cell protrusion / PPIs / 胃底腺ポリープ / プロトンポンプ阻害薬 / 胃底腺ポリープ様病変 / 消化器 / 胃 / ヘリコバクター・ピロリ菌 |
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| Outline of Final Research Achievements |
Our study showed that hyperplastic foveolar cells and parietal cells in fundic gland polyps were significantly more frequent with PPI treatment than without PPI treatment. Furthermore, multiplex immunohistochemical stains showed the double-positive cell ratio of MUC5AC, a marker of foveolar epithelium, and Ki67 the in the deep mucosal layers of FGPs were significantly higher with PPI treatment than without PPI treatment. In the gene analysis, b-catenin gene mutations were found in only 9.7% of FGPs with PPI treatment.Enlargement of fundic gland cysts due to parietal cell protrusion and foveolar cell hyperplasia, especially in the deep layer of fundic glands, may promote the enlargement of FGPs in patients on PPIs.
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| Academic Significance and Societal Importance of the Research Achievements |
プロトンポンプ阻害薬で増大する胃底腺ポリープの増大のメカニズムの一部を明らかにすることが出来た。近年、腫瘍性異型を伴った胃底腺ポリープや出血を伴った胃底腺ポリープの報告も増えており、これらのポリープ発生、制御に役立つ新たな知見であるかもしれない。
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