| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Fibroblast activation protein, induced in cancer-associated fibroblast (CAF) by co-culture with esophageal squamous cell carcinoma (ESCC) cell, triggered secretion of CCL2 and IL-6 through activation of PTEN/Akt and MEK/Erk signaling resulting in the migration/invasion promotion in ESCC cell and macrophage (Mφ) as well as M2 differentiation of Mφ. Plasminogen activator inhibitor-1 (PAI-1), induced during CAF-like differentiation, promoted migration/invasion in ESCC cell and Mφ activated PTEN/Akt and MEK/Erk signaling through LRP1 receptor. High expression of PAI-1 in the cancer stroma and LRP1 in the cancer nest significantly associated with a poor prognosis of ESCC patients.
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