| Project/Area Number |
17K08709
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Teikyo University |
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Principal Investigator |
Koike Ryoko 帝京大学, 医学部, 助手 (80535063)
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| Co-Investigator(Kenkyū-buntansha) |
坂本 優 公益財団法人佐々木研究所, 附属研究所, 副院長(移行) (20260101)
綾部 琢哉 帝京大学, 医学部, 教授 (00272568)
中川 俊介 帝京大学, 医学部, 講師 (70270874)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 卵巣明細胞腺癌 / 蛍光標識2次元ディファレンシャルゲル電気泳動法 / パクリタキセル / NNMT / 卵巣明細胞癌 / 抗がん剤耐性 / 化学療法 |
|---|
| Outline of Final Research Achievements |
Fluorescence-labeled two-dimensional differential gel electrophoresis showed that the expression of lab-named protein 1 was higher in ovarian clear cell carcinoma cell lines 1 and 2, which are poor responders to paclitaxel, than in cell lines 3 and 4, which are good responders to paclitaxel. The expression of lab-name protein 1 was higher in cell line 1 and 2 than in cell line 3 and 4. Kaplan-Meier survival analysis of 39 cases of ovarian adenocarcinoma showed that there were no deaths in the group with low expression of lab name protein1.
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| Academic Significance and Societal Importance of the Research Achievements |
卵巣明細胞腺癌ではラボネームprotein1が下がるとパクリタキセルの感受性が上がり、生命予後がよくなる可能性がある。
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