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The significance of host immune status and microRNA abnormalities in EBV-associated tumor

Research Project

Project/Area Number 17K08716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionThe University of Tokyo

Principal Investigator

Shinozaki-Ushiku Aya  東京大学, 医学部附属病院, 講師 (60581824)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsEBウイルス / microRNA / 潜伏感染遺伝子 / Micro RNA / MicroRNA / マイクロRNA / 宿主免疫
Outline of Final Research Achievements

To explore the significance of immune host status during EBV-associated oncogenesis, analyses of EBV-microRNAs expression, latent gene expression and EBV copy number were performed using 90 cases of EBV-related tumors. EBV-microRNA expression and copy numbers were high in the relatively immunocompetent hosts. In addition, EBV-microRNA expression was higher in lymphoproliferative disorders than in monomorphic malignant lymphomas, suggesting the significance of EBV-microRNA in early stage of oncogenesis.

Academic Significance and Societal Importance of the Research Achievements

本研究ではEBVに関連した上皮性あるいはリンパ球性の腫瘍発生の過程において,比較的早期の段階からEBV由来のmicroRNAの発現が重要であることを明らかにした.高齢化や移植医療の発達などにより,潜在的な免疫不全状態の患者が増加し,これに伴ってEBVに関連した腫瘍発生が増加することが予想される.本研究がEBVに関連した腫瘍発生の機序の一端を明らかにすることにより,診断や治療における有益な情報となる可能性がある.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2020 2019 2018 2017 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Extranodal NK/T-cell lymphoma of the nasal cavity developed in a patient with intestinal Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder.2018

    • Author(s)
      Furuya G, Abe H, Shinozaki-Ushiku A, Yamashita A, Ihara S, Hirata Y, Chiba A, Fujioka Y, Kurokawa M, Koike K, Fukayama M.
    • Journal Title

      Pathol Res Pract

      Volume: 214 Issue: 7 Pages: 1051-1055

    • DOI

      10.1016/j.prp.2018.05.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8+/Foxp3+ T cells2018

    • Author(s)
      Abe Hiroyuki、Saito Ruri、Ichimura Takashi、Iwasaki Akiko、Yamazawa Sho、Shinozaki-Ushiku Aya、Morikawa Teppei、Ushiku Tetsuo、Yamashita Hiroharu、Seto Yasuyuki、Fukayama Masashi
    • Journal Title

      Virchows archiv

      Volume: 印刷中 Issue: 4 Pages: 643-651

    • DOI

      10.1007/s00428-018-2332-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features and outcomes of secondary intraocular lymphoma2017

    • Author(s)
      Karakawa Ayako、Taoka Kazuki、Kaburaki Toshikatsu、Tanaka Rie、Shinozaki-Ushiku Aya、Hayashi Hiroyuki、Miyagi-Maeshima Akiko、Nishimura Yu、Uekusa Toshimasa、Kojima Yui、Fukayama Masashi、Kurokawa Mineo、Aihara Makoto
    • Journal Title

      British Journal of Haematology

      Volume: - Issue: 4 Pages: 668-671

    • DOI

      10.1111/bjh.15005

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polymorphic lymphoproliferative disorders in patients with rheumatoid arthritis are associated with a better clinical outcome2017

    • Author(s)
      Tsukui Daisuke、Kanda Hiroko、Shinozaki-Ushiku Aya、Tateishi Shoko、Takeshima Yusuke、Nagafuchi Yasuo、Sasaki Oh、Iwasaki Yukiko、Harada Hiroaki、Shibuya Mihoko、Sumitomo Shuji、Shoda Hirofumi、Kubo Kanae、Fujio Keishi、Nakamura Fumihiko、Kurokawa Mineo、Fukayama Masashi、Yamamoto Kazuhiko
    • Journal Title

      Modern Rheumatology

      Volume: 23 Issue: 4 Pages: 1-5

    • DOI

      10.1080/14397595.2017.1387223

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mizuno H, Koya J, Fujioka Y, Ibaraki T, Nakamura F, Hayashi A, Shinozaki-Ushiku A, Akamatsu N, Hasegawa K, Kokudo N, Fukuyama M, Kurokawa M.2017

    • Author(s)
      Extranodal NK/T cell lymphoma in a living donor liver transplant recipient.
    • Journal Title

      Ann Hematol.

      Volume: Mar 9. Issue: 6 Pages: 1051-1052

    • DOI

      10.1007/s00277-017-2969-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] EBウイルス関連胃癌2017

    • Author(s)
      牛久綾・牛久哲男
    • Journal Title

      消化器・肝臓内科

      Volume: 2 Pages: 49-54

    • Related Report
      2017 Research-status Report
  • [Journal Article] EBウイルス関連胃癌とH.pylori2017

    • Author(s)
      牛久綾・牛久哲男
    • Journal Title

      臨床消化器内科

      Volume: 32 Pages: 1497-1502

    • Related Report
      2017 Research-status Report
  • [Presentation] EBV関連腫瘍における宿主の免疫状態およびmicroRNA異常の意義の解明2020

    • Author(s)
      久米 絢子, 牛久 綾, 牛久 哲男
    • Organizer
      第109回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] EBV関連腫瘍における宿主の免疫状態およびmicroRNA発現異常の意義の解明2019

    • Author(s)
      久米絢子, 牛久綾, 国田朱子, 深山正久, 牛久哲男
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Epstein-Barr virus-associated gastric carcinoma -The roles of cellular and viral microRNAs in its carcinogenesis-2017

    • Author(s)
      Aya Shinozaki-Ushiku
    • Organizer
      Belfast Pathology 2017 (10th Joint Meeting of the British Division of the International Academy of Pathology and the Pathologocal Society of Great Britaion & Ireland)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 東京大学医学部 人体病理学・病理診断学ホームページ

    • URL

      http://pathol.umin.ac.jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学医学部 人体病理学・病理診断学分野のホームページ

    • URL

      http://pathol.umin.ac.jp/

    • Related Report
      2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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