SWI/SNF chromatin-remodeling complex status in tumors with sarcomatoid changes

• Project/Area Number: 17K08722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kyushu University
• Principal Investigator: Kohashi Kenichi 九州大学, 医学研究院, 准教授 (10529879)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: rhabdoid / sarcomatoid / SWI/SNF / gastric cancer / solid-type / 腎細胞癌 / SMARCA4 / 膀胱がん / 肉腫様変化 / ラブドイド様変化 / 人体病理学 / SWI/SNF型クロマチン再構成因子 / SMARCB1/INI1

Outline of Final Research Achievements

Urothelial carcinoma (UC) with sarcomatoid changes and solid-type poorly differentiated adenocarcinoma (solid-PDA) of the stomach show aberrant expressions of SWI/SNF chromatin remodeling complex-related proteins. Its related proteins may have an important role in tumorigenesis of UC with sarcomatoid changes and solid-PDA of the stomach.
In renal cell carcinoma (RCC), there is no significant correlation between expressions of SWI/SNF chromatin remodeling complex-related proteins and histological high-grade malignant transformation such as sarcomatoid and rhabdoid changes. However, the frequency of aberrant SMARCA4 immunoexpression of a sarcomatoid or rhabdoid component in clear cell RCC (ccRCC) was significantly higher than that in non-ccRCC. The evaluation of SMARCA4 immunoexpression may be a useful diagnostic tool to help distinguish ccRCC from non-ccRCC.

Academic Significance and Societal Importance of the Research Achievements

癌腫において、形態学的にとらえることができる高悪性度変化である肉腫様変化が、SWI/SNF型クロマチン再構成因子複合体関連蛋白異常と関連している可能性が示唆された。このことは、高悪性度変化へのリスクの評価や治療、また、それを抑制するような方策開発の一助になると考えられる。

Research Products

• [Journal Article] Diagnostic utility of pan‐Trk immunohistochemistry for inflammatory myofibroblastic tumours (2020)
  • Author(s): Yamamoto Hidetaka、Nozaki Yui、Kohashi Kenichi、Kinoshita Izumi、Oda Yoshinao
  • Journal Title: Histopathology Volume: - Issue: 5 Pages: 774-778
  • DOI: 10.1111/his.14010
  • Peer Reviewed
• [Journal Article] Comparative Study of Myxofibrosarcoma With Undifferentiated Pleomorphic Sarcoma (2020)
  • Author(s): Yoshimoto Masato、Yamada Yuichi、Ishihara Shin、Kohashi Kenichi、Toda Yu、Ito Yoshihiro、Yamamoto Hidetaka、Furue Masutaka、Nakashima Yasuharu、Oda Yoshinao
  • Journal Title: The American Journal of Surgical Pathology Volume: 44 Issue: 1 Pages: 87-97
  • DOI: 10.1097/pas.0000000000001389
  • Peer Reviewed
• [Journal Article] Solid‐type poorly differentiated adenocarcinoma of the stomach: Deficiency of mismatch repair and SWI/SNF complex (2020)
  • Author(s): Tsuruta Shinichi、Kohashi Kenichi、Yamada Yuichi、Fujiwara Minako、Koga Yutaka、Ihara Eikichi、Ogawa Yoshihiro、Oki Eiji、Nakamura Masafumi、Oda Yoshinao
  • Journal Title: Cancer Science Volume: 111 Issue: 3 Pages: 1008-1019
  • DOI: 10.1111/cas.14301
  • Peer Reviewed
• [Journal Article] Activation of the Akt/mammalian Target of Rapamycin Pathway in Combined Hepatocellular Carcinoma and Cholangiocarcinoma: Significant Correlation Between p-4E-BP1 Expression in Cholangiocarcinoma Component and Prognosis (2020)
  • Author(s): Okumura Y, Kohashi K, Tanaka Y, Kato M, Maehara Y, Ogawa Y, Oda Y.
  • Journal Title: Virchows Arch. Volume: -
  • Peer Reviewed
• [Journal Article] Soft Tissue Special Issue: Skeletal Muscle Tumors: A Clinicopathological Review (2020)
  • Author(s): Kohashi K, Kinoshita I, Oda Y.
  • Journal Title: Head and Neck Pathology Volume: 14 Pages: 12-20
  • Peer Reviewed
• [Journal Article] Establishment and Characterization of a Novel Primitive Yolk Sac Tumour Cell Line, TC587 (2020)
  • Author(s): IWASAKI TAKESHI、KOHASHI KENICHI、OHNO MASASUKE、TAGUCHI TOMOAKI、ODA YOSHINAO
  • Journal Title: Anticancer Research Volume: 40 Issue: 2 Pages: 759-766
  • DOI: 10.21873/anticanres.14007
  • Peer Reviewed / Open Access
• [Journal Article] Co-expression of IDO1 and PD-L1 in lung squamous cell carcinoma: Potential targets of novel combination therapy (2019)
  • Author(s): Takada Kazuki、Kohashi Kenichi、Shimokawa Mototsugu、Haro Akira、Osoegawa Atsushi、Tagawa Tetsuzo、Seto Takashi、Oda Yoshinao、Maehara Yoshihiko
  • Journal Title: Lung Cancer Volume: 128 Pages: 26-32
  • DOI: 10.1016/j.lungcan.2018.12.008
  • Peer Reviewed
• [Journal Article] A case of autonomous cortisol secretion in a patient with subclinical Cushing’s syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone (2019)
  • Author(s): Sakaguchi Chihiro、Ashida Kenji、Kohashi Kenichi、Ohe Kenji、Fujii Yoichi、Yano Seiichi、Matsuda Yayoi、Sakamoto Shohei、Sakamoto Ryuichi、Oda Yoshinao、Nomura Masatoshi、Ogawa Yoshihiro
  • Journal Title: BMC Endocrine Disorders Volume: 19 Issue: 1
  • DOI: 10.1186/s12902-019-0345-8
  • Peer Reviewed
• [Journal Article] Wnt/β-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development (2019)
  • Author(s): Fujii Shinsuke、Nagata Kengo、Matsumoto Shinji、Kohashi Ken-ichi、Kikuchi Akira、Oda Yoshinao、Kiyoshima Tamotsu、Wada Naohisa
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 4257-4257
  • DOI: 10.1038/s41598-019-39686-1
  • Peer Reviewed / Open Access
• [Journal Article] Glypican-3 expression in malignant small round cell tumors. (2019)
  • Author(s): Shibui Y, Miyoshi K, Kohashi K, Kinoshita Y, Kuda M, Yamamoto H, Taguchi T, Oda Y
  • Journal Title: Oncol Lett. Volume: 17 Pages: 3523-3528
  • DOI: 10.3892/ol.2019.9976
  • Peer Reviewed
• [Journal Article] Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma (2019)
  • Author(s): Takada Kazuki、Shimokawa Mototsugu、Tanaka Kensuke、Kohashi Kenichi、Haro Akira、Osoegawa Atsushi、Tagawa Tetsuzo、Azuma Koichi、Okamoto Isamu、Oda Yoshinao、Mori Masaki
  • Journal Title: PLOS ONE Volume: 14 Issue: 6 Pages: e0217991-e0217991
  • DOI: 10.1371/journal.pone.0217991
  • Peer Reviewed
• [Journal Article] Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall. (2019)
  • Author(s): Yorita K, Togashi Y, Nakagawa H, Miyazaki K, Sakata S, Baba S, Takeuchi K, Hayashi Y, Murakami I, Kuroda N, Oda Y, Kohashi K, Yamada Y, Kiyozawa D, Michal M, Michal M.
  • Journal Title: Pathol Int. Volume: 69 Issue: 6 Pages: 366-371
  • DOI: 10.1111/pin.12796
  • Peer Reviewed
• [Journal Article] A newborn case of jejunal ALK-negative inflammatory myofibroblastic tumor with ETV6-NTRK3 fusion. (2019)
  • Author(s): Masuda Y, Tsukamoto Y, Zenitani M, Oda Y, Kinoshita I, Kohashi K, Takemoto J, Hirota S, Shibata A, Koda T, Takeshima Y.
  • Journal Title: Pediatr Blood Cancer Volume: 10 Issue: 10 Pages: 27902-27902
  • DOI: 10.1002/pbc.27902
  • Peer Reviewed
• [Journal Article] Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial (2019)
  • Author(s): Shimizu Yasuhiro、Yoshikawa Toshiaki、Kojima Takashi、Shoda Kayoko、Nosaka Kazuto、Mizuno Shoichi、Wada Satoshi、Fujimoto Yuki、Sasada Tetsuro、Kohashi Kenichi、Bando Hideaki、Endo Itaru、Nakatsura Tetsuya
  • Journal Title: Cancer Science Volume: 110 Issue: 10 Pages: 3049-3060
  • DOI: 10.1111/cas.14165
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological Review of Solitary Fibrous Tumors: Dedifferentiation Is a Major Cause of Patient Death (2019)
  • Author(s): Yamada Y, Kohashi K, Kinoshita I, Yamamoto H, Iwasaki T, Yoshimoto M, Ishihara S, Toda Y, Itou Y, Koga Y, Hashisako M, Nozaki Y, Kiyozawa D, Kitahara D, Inoue T, Mukai M, Honda Y, Toyokawa G, Tsuchihashi K, Matsushita Y, Fushimi F, Taguchi K, Tamiya S, Oshiro Y, Furue M, Nakashima Y, Suzuki S, Iwaki T, Oda Y.
  • Journal Title: Virchows Arch. Volume: 475 Pages: 467-477
  • Peer Reviewed
• [Journal Article] Efficacy of the NCCV Cocktail‐1 vaccine for refractory pediatric solid tumors: A phase I clinical trial (2019)
  • Author(s): Akazawa Yu、Hosono Ako、Yoshikawa Toshiaki、Kaneda Hide、Nitani Chika、Hara Junichi、Kinoshita Yoshiaki、Kohashi Kenichi、Manabe Atsushi、Fukutani Miki、Wakabayashi Masashi、Sato Akihiro、Shoda Kayoko、Shimomura Manami、Mizuno Shoichi、Nakamoto Yasunari、Nakatsura Tetsuya
  • Journal Title: Cancer Science Volume: 110 Issue: 12 Pages: 3650-3662
  • DOI: 10.1111/cas.14206
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of Liver Fibrosis Using CT Under Respiratory Control: New Attempt Using Deformation Vectors Obtained by Non-rigid Registration Technique (2019)
  • Author(s): NISHIE AKIHIRO、AKAHORI SADATO、ASAYAMA YOSHIKI、ISHIGAMI KOUSEI、USHIJIMA YASUHIRO、KAKIHARA DAISUKE、NAKAYAMA TOMOHIRO、TAKAYAMA YUKIHISA、FUJITA NOBUHIRO、MORITA KOICHIRO、ISHIMATSU KEISUKE、TAKAO SEIICHIRO、YOSHIZUMI TOMOHARU、KOHASHI KENICHI、LI YUANZHONG、HONDA HIROSHI
  • Journal Title: Anticancer Research Volume: 39 Issue: 3 Pages: 1417-1424
  • DOI: 10.21873/anticanres.13257
  • Peer Reviewed
• [Journal Article] Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients (2019)
  • Author(s): Souzaki Ryota、Kawakubo Naonori、Matsuura Toshiharu、Yoshimaru Koichiro、Koga Yuhki、Takemoto Junkichi、Shibui Yuichi、Kohashi Kenichi、Hayashida Makoto、Oda Yoshinao、Ohga Shouichi、Taguchi Tomoaki
  • Journal Title: Pediatric Surgery International Volume: 35 Issue: 5 Pages: 551-557
  • DOI: 10.1007/s00383-019-04458-5
  • Peer Reviewed
• [Journal Article] HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors (2019)
  • Author(s): Takemoto Junkichi、Kuda Masaaki、Kohashi Kenichi、Yamada Yuichi、Koga Yutaka、Kinoshita Izumi、Souzaki Ryota、Taguchi Tomoaki、Oda Yoshinao
  • Journal Title: Human Pathology Volume: 85 Pages: 162-167
  • DOI: 10.1016/j.humpath.2018.11.004
  • Peer Reviewed
• [Journal Article] Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor (2018)
  • Author(s): Abe Tatsuro、Kohashi Kenichi、Takemoto Junkichi、Kinoshita Fumio、Eto Masatoshi、Oda Yoshinao
  • Journal Title: Journal of Cancer Volume: 9 Issue: 23 Pages: 4440-4448
  • DOI: 10.7150/jca.25279
  • Peer Reviewed
• [Journal Article] Primary intrahepatic cholangiocarcinoma with sarcomatous stroma: case report and review of the literature (2018)
  • Author(s): Yugawa Kyohei、Yoshizumi Tomoharu、Mano Yohei、Harada Noboru、Itoh Shinji、Ikegami Toru、Soejima Yuji、Fujita Nobuhiro、Kohashi Kenichi、Aishima Shinichi、Oda Yoshinao、Mori Masaki
  • Journal Title: Surgical Case Reports Volume: 4 Issue: 1 Pages: 138-138
  • DOI: 10.1186/s40792-018-0543-z
  • Peer Reviewed
• [Journal Article] Radiological Features of IDO1+/PDL1+ Lung Adenocarcinoma: A Retrospective Single-institution Study (2018)
  • Author(s): TAKADA KAZUKI、TOYOKAWA GOUJI、TAGAWA TETSUZO、SHIMOKAWA MOTOTSUGU、KOHASHI KENICHI、HARO AKIRA、OSOEGAWA ATSUSHI、ODA YOSHINAO、MAEHARA YOSHIHIKO
  • Journal Title: Anticancer Research Volume: 38 Issue: 9 Pages: 5295-5303
  • DOI: 10.21873/anticanres.12856
  • Peer Reviewed
• [Journal Article] Indoleamine 2,3-dioxygenase 1 and programmed cell death-ligand 1 co-expression correlates with aggressive features in lung adenocarcinoma (2018)
  • Author(s): Kozuma Yuka、Takada Kazuki、Toyokawa Gouji、Kohashi Kenichi、Shimokawa Mototsugu、Hirai Fumihiko、Tagawa Tetsuzo、Okamoto Tatsuro、Oda Yoshinao、Maehara Yoshihiko
  • Journal Title: European Journal of Cancer Volume: 101 Pages: 20-29
  • DOI: 10.1016/j.ejca.2018.06.020
  • Peer Reviewed
• [Journal Article] The Utility of Muscle-Sparing Axillar Skin Crease Incision with Thoracoscopic Surgery in Children (2018)
  • Author(s): Souzaki Ryota、Kawakubo Naonori、Miyoshi Kina、Obata Satoshi、Kinoshita Yoshiaki、Takemoto Junkichi、Kohashi Kenichi、Oda Yoshinao、Taguchi Tomoaki
  • Journal Title: Journal of Laparoendoscopic & Advanced Surgical Techniques Volume: 28 Issue: 11 Pages: 1378-1382
  • DOI: 10.1089/lap.2018.0169
  • Peer Reviewed
• [Journal Article] Successful chemotherapeutic treatment for metastatic littoral cell angioma (2018)
  • Author(s): Takayoshi Kotoe、Doi Goro、Tsuruta Nobuhiro、Yoshihiro Tomoyasu、Nio Kenta、Tsuchihashi Kenji、Ariyama Hiroshi、Odawara Jun、Shimoda Shinji、Kohashi Kenichi、Oda Yoshinao、Itoh Shinji、Harimoto Norifumi、Maehara Yoshihiko、Kusaba Hitoshi、Akashi Koichi、Baba Eishi
  • Journal Title: Medicine Volume: 97 Issue: 15 Pages: e0378-e0378
  • DOI: 10.1097/md.0000000000010378
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemical evaluation of H3K27 trimethylation in malignant peripheral nerve sheath tumors (2018)
  • Author(s): Otsuka Hiroshi、Kohashi Kenichi、Yoshimoto Masato、Ishihara Shin、Toda Yu、Yamada Yuichi、Yamamoto Hidetaka、Nakashima Yasuharu、Oda Yoshinao
  • Journal Title: Pathology - Research and Practice Volume: 214 Issue: 3 Pages: 417-425
  • DOI: 10.1016/j.prp.2017.12.015
  • Peer Reviewed
• [Journal Article] PD-L1 expression according to the EGFR status in primary lung adenocarcinoma (2018)
  • Author(s): Takada Kazuki、Toyokawa Gouji、Tagawa Tetsuzo、Kohashi Kenichi、Shimokawa Mototsugu、Akamine Takaki、Takamori Shinkichi、Hirai Fumihiko、Shoji Fumihiro、Okamoto Tatsuro、Oda Yoshinao、Maehara Yoshihiko
  • Journal Title: Lung Cancer Volume: 116 Pages: 1-6
  • DOI: 10.1016/j.lungcan.2017.12.003
  • Peer Reviewed
• [Journal Article] SWI/SNF Chromatin-remodeling Complex Status in SMARCB1/INI1-preserved Epithelioid Sarcoma (2018)
  • Author(s): Kohashi Kenichi、Yamamoto Hidetaka、Yamada Yuichi、Kinoshita Izumi、Taguchi Tomoaki、Iwamoto Yukihide、Oda Yoshinao
  • Journal Title: The American Journal of Surgical Pathology Volume: 42 Issue: 3 Pages: 312-318
  • DOI: 10.1097/pas.0000000000001011
  • Peer Reviewed
• [Journal Article] Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone (2018)
  • Author(s): Yamamoto Hidetaka、Iwasaki Takeshi、Yamada Yuichi、Matsumoto Yoshihiro、Otsuka Hiroshi、Yoshimoto Masato、Kohashi Kenichi、Taguchi Kenichi、Yokoyama Ryohei、Nakashima Yasuharu、Oda Yoshinao
  • Journal Title: Human Pathology Volume: 73 Pages: 41-50
  • DOI: 10.1016/j.humpath.2017.11.020
  • Peer Reviewed
• [Journal Article] Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion (2018)
  • Author(s): Kohsaka Shinji、Saito Tsuyoshi、Akaike Keisuke、Suehara Yoshiyuki、Hayashi Takuo、Takagi Tatsuya、Kaneko Kazuo、Ueno Toshihide、Kojima Shinya、Kohashi Ken-ichi、Mano Hiroyuki、Oda Yoshinao、Yao Takashi
  • Journal Title: Human Pathology Volume: 72 Pages: 167-173
  • DOI: 10.1016/j.humpath.2017.08.017
  • Peer Reviewed / Open Access
• [Journal Article] Phase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors (2017)
  • Author(s): Tsuchiya Nobuhiro、Hosono Ako、Yoshikawa Toshiaki、Shoda Kayoko、Nosaka Kazuto、Shimomura Manami、Hara Junichi、Nitani Chika、Manabe Atsushi、Yoshihara Hiroki、Hosoya Yosuke、Kaneda Hide、Kinoshita Yoshiaki、Kohashi Kenichi、Yoshimura Kenichi、Fujinami Norihiro、Saito Keigo、Mizuno Shoichi、Nakatsura Tetsuya
  • Journal Title: OncoImmunology Volume: 7 Issue: 1 Pages: e1377872-e1377872
  • DOI: 10.1080/2162402x.2017.1377872
  • Peer Reviewed / Open Access
• [Journal Article] Highlighted version successful resection of a tracheal metastasis of rectal cancer: a case report (2017)
  • Author(s): Akamine Takaki、Toyokawa Gouji、Kohashi Kenichi、Matsubara Taichi、Kozuma Yuka、Haratake Naoki、Takamori Shinkichi、Katsura Masakazu、Takada Kazuki、Shoji Fumihiro、Okamoto Tatsuro、Oda Yoshinao、Maehara Yoshihiko
  • Journal Title: Journal of Thoracic Disease Volume: 9 Issue: 9 Pages: E797-E800
  • DOI: 10.21037/jtd.2017.07.94
  • Peer Reviewed
• [Journal Article] Association Between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer. (2017)
  • Author(s): Takada K, Toyokawa G, Tagawa T, Kohashi K, Akamine T, Takamori S, Hirai F, Shoji F, Okamoto T, Oda Y, Maehara Y
  • Journal Title: Anticancer Res. Volume: 12 Pages: 7073-7082
  • Peer Reviewed
• [Journal Article] A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance (2017)
  • Author(s): Kuma Yuki、Yamada Yuichi、Yamamoto Hidetaka、Kohashi Kenichi、Ito Takamichi、Furue Masutaka、Oda Yoshinao
  • Journal Title: Human Pathology Volume: 70 Pages: 55-61
  • DOI: 10.1016/j.humpath.2017.10.004
  • Peer Reviewed
• [Journal Article] Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma (2017)
  • Author(s): Tsuruta Nobuhiro、Takayoshi Kotoe、Arita Shuji、Aikawa Tomomi、Ariyama Hiroshi、Kusaba Hitoshi、Ohuchida Kenoki、Nagai Eishi、Kohashi Kenichi、Hirahashi Minako、Inadomi Kyoko、Tanaka Mamoru、Sagara Kosuke、Okumura Yuta、Nio Kenta、Nakano Michitaka、Nakamura Masafumi、Oda Yoshinao、Akashi Koichi、Baba Eishi
  • Journal Title: Oncology Letters Volume: 14 Issue: 2 Pages: 1500-1504
  • DOI: 10.3892/ol.2017.6299
  • Peer Reviewed
• [Journal Article] Soft tissue sarcomas: From a morphological to a molecular biological approach (2017)
  • Author(s): Oda Yoshinao、Yamamoto Hidetaka、Kohashi Kenichi、Yamada Yuichi、Iura Kunio、Ishii Takeaki、Maekawa Akira、Bekki Hirofumi
  • Journal Title: Pathology International Volume: 67 Issue: 9 Pages: 435-446
  • DOI: 10.1111/pin.12565
  • Peer Reviewed
• [Journal Article] MAGEA4 expression in bone and soft tissue tumors: its utility as a target for immunotherapy and diagnostic marker combined with NY-ESO-1 (2017)
  • Author(s): Iura Kunio、Kohashi Kenichi、Ishii Takeaki、Maekawa Akira、Bekki Hirofumi、Otsuka Hiroshi、Yamada Yuichi、Yamamoto Hidetaka、Matsumoto Yoshihiro、Iwamoto Yukihide、Oda Yoshinao
  • Journal Title: Virchows Archiv Volume: 471 Issue: 3 Pages: 383-392
  • DOI: 10.1007/s00428-017-2206-z
  • Peer Reviewed
• [Journal Article] Alteration of PDGFR β -Akt-mTOR pathway signaling in fibrosarcomatous transformation of dermatofibrosarcoma protuberans (2017)
  • Author(s): Hiraki-Hotokebuchi Yuka、Yamada Yuichi、Kohashi Kenichi、Yamamoto Hidetaka、Endo Makoto、Setsu Nokitaka、Yuki Kuma、Ito Takamichi、Iwamoto Yukihide、Furue Masutaka、Oda Yoshinao
  • Journal Title: Human Pathology Volume: 67 Pages: 60-68
  • DOI: 10.1016/j.humpath.2017.07.001
  • Peer Reviewed
• [Journal Article] Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions (2017)
  • Author(s): Tanaka Mio、Kohashi Kenichi、Kushitani Kei、Yoshida Misa、Kurihara Sho、Kawashima Masumi、Ueda Yuka、Souzaki Ryota、Kinoshita Yoshiaki、Oda Yoshinao、Takeshima Yukio、Hiyama Eiso、Taguchi Tomoaki、Tanaka Yukichi
  • Journal Title: Human Pathology Volume: 66 Pages: 177-182
  • DOI: 10.1016/j.humpath.2017.06.013
  • Peer Reviewed / Open Access
• [Journal Article] Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report (2017)
  • Author(s): Okumura Yukihiko、Kohashi Kenichi、Wang Huanlin、Kato Masaki、Maehara Yoshihiko、Ogawa Yoshihiro、Oda Yoshinao
  • Journal Title: Pathology - Research and Practice Volume: 213 Issue: 10 Pages: 1322-1326
  • DOI: 10.1016/j.prp.2017.06.001
  • Peer Reviewed
• [Journal Article] SMARCA4-deficient thoracic sarcoma: report of a case and insights into how to reach the diagnosis using limited samples and resources (2017)
  • Author(s): Kuwamoto Satoshi、Matsushita Michiko、Takeda Kenichi、Tanaka Natsumi、Endo Yukari、Yamasaki Akira、Kohashi Kenichi、Oda Yoshinao、Horie Yasushi
  • Journal Title: Human Pathology Volume: 70 Pages: 92-97
  • DOI: 10.1016/j.humpath.2017.05.024
  • Peer Reviewed
• [Journal Article] Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: A case report (2017)
  • Author(s): Yoshihiro Tomoyasu、Nio Kenta、Tsuchihashi Kenji、Ariyama Hiroshi、Kohashi Kenichi、Tsuruta Nobuhiro、Hanamura Fumiyasu、Inadomi Kyoko、Ito Mamoru、Sagara Kosuke、Okumura Yuta、Nakano Michitaka、Arita Shuji、Kusaba Hitoshi、Oda Yoshinao、Akashi Koichi、Baba Eishi
  • Journal Title: Molecular and Clinical Oncology Volume: 6 Issue: 6 Pages: 866-870
  • DOI: 10.3892/mco.2017.1240
  • Peer Reviewed
• [Journal Article] Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma (2017)
  • Author(s): Ishii Takeaki、Kohashi Kenichi、Ootsuka Hiroshi、Iura Kunio、Maekawa Akira、Yamada Yuichi、Bekki Hirofumi、Yoshimoto Masato、Yamamoto Hidetaka、Iwamoto Yukihide、Oda Yoshinao
  • Journal Title: Pathology - Research and Practice Volume: 213 Issue: 6 Pages: 634-638
  • DOI: 10.1016/j.prp.2017.04.022
  • Peer Reviewed
• [Journal Article] A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma (2017)
  • Author(s): Takizawa Katsumi、Kohashi Kenichi、Negishi Takahito、Taguchi Kenichi、Yamada Yuichi、Nakamura Motonobu、Oda Yoshinao
  • Journal Title: Pathology - Research and Practice Volume: 213 Issue: 6 Pages: 702-705
  • DOI: 10.1016/j.prp.2017.04.017
  • Peer Reviewed
• [Journal Article] Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans (2017)
  • Author(s): K Tsuchihashi, H Kusaba, Y Yamada, Y Okumura, H Kumagai, M Komoda, K Uchino, T Yoshihiro, N Tsuruta, F Hanamura, K Inadomi, M Ito, K Sagara, M Nakano, K Nio, K Kohashi, S Arita, H Ariyama, R Tominaga, Y Oda, K Akashi, E Baba
  • Journal Title: Molecular and Clinical Oncology Volume: 印刷中 Issue: 5 Pages: 665-668
  • DOI: 10.3892/mco.2017.1197
  • Peer Reviewed
• [Journal Article] HIF-1α, MDM2, CDK4, and p16 expression in ischemic fasciitis, focusing on its ischemic condition (2017)
  • Author(s): Yamada Yuichi、Kinoshita Izumi、Kohashi Kenichi、Yamamoto Hidetaka、Kuma Yuki、Ito Takamichi、Koda Kenji、Kisanuki Atsushi、Kurosawa Manabu、Yoshimura Michiko、Furue Masutaka、Oda Yoshinao
  • Journal Title: Virchows Archiv Volume: 471 Issue: 1 Pages: 117-122
  • DOI: 10.1007/s00428-017-2122-2
  • Peer Reviewed
• [Journal Article] Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors (2017)
  • Author(s): Bekki Hirofumi、Yamamoto Hidetaka、Takizawa Katsumi、Iwasaki Takeshi、Otsuka Hiroshi、Yamada Yuichi、Kohashi Kenichi、Harimaya Katsumi、Iwamoto Yukihide、Oda Yoshinao
  • Journal Title: Pathology - Research and Practice Volume: 213 Issue: 6 Pages: 674-679
  • DOI: 10.1016/j.prp.2016.12.001
  • Peer Reviewed
• [Journal Article] Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma (2017)
  • Author(s): Wang Huanlin、Kohashi Kenichi、Yoshizumi Tomoharu、Okumura Yukihiko、Tanaka Yuki、Shimokawa Masahiro、Iwasaki Takeshi、Aishima Shinichi、Maehara Yoshihiko、Oda Yoshinao
  • Journal Title: Human Pathology Volume: 64 Pages: 69-75
  • DOI: 10.1016/j.humpath.2017.03.007
  • Peer Reviewed
• [Journal Article] Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status. (2017)
  • Author(s): Yamashita K, Kohashi K, Yamada Y, Nishida Y, Urakawa H, Oda Y, Toyokuni S.
  • Journal Title: Hum Pathol. Volume: 印刷中 Pages: 63-69
  • DOI: 10.1016/j.humpath.2017.02.007
  • Peer Reviewed
• [Journal Article] Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes. (2017)
  • Author(s): Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y.
  • Journal Title: Virchows Arch. Volume: 470 Issue: 4 Pages: 373-380
  • DOI: 10.1007/s00428-017-2072-8
  • Peer Reviewed
• [Journal Article] Oncogenic roles of SMARCB1/INI1 and its deficient tumors. (2017)
  • Author(s): Kohashi K, Oda Y.
  • Journal Title: Cancer Sci. Volume: 印刷中 Issue: 4 Pages: 547-552
  • DOI: 10.1111/cas.13173
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 肉腫様変化やラブドイドを伴う腎癌におけるクロマチンリモデリング因子に関する検討 (2019)
  • Author(s): 木下史生、孝橋賢一、江藤正俊、小田義直
  • Organizer: 第108回日本病理学会総会
• [Presentation] 炎症性筋線維芽細胞腫瘍における pan-TRK 免疫組織化学染色の診断的有用性 (2019)
  • Author(s): 山元英崇、野崎優衣、孝橋賢一、田口健一、小田義直
  • Organizer: 第108回日本病理学会総会
• [Presentation] 粘液線維肉腫の臨床病理学的検討：未分化多形肉腫様変化 (2019)
  • Author(s): 吉本昌人、山田裕一、石原新、孝橋賢一、戸田雄、伊東良広、山元英崇、古江増隆、中島康晴、小田義直
  • Organizer: 第108回日本病理学会総会
• [Presentation] 脱分化型脂肪肉腫において MDM2/HMGA2 の増幅比率は予後と相関する (2019)
  • Author(s): 山下享子、孝橋賢一、山田裕一、赤塚慎也、小田義直
  • Organizer: 第108回日本病理学会総会
• [Presentation] Hormone receptor-associated low-grade myoepithelial tumor:SMARCB1/INI1欠失軟部腫瘍の14症例 (2019)
  • Author(s): 木下伊寿美、孝橋賢一、山田裕一、山元英崇、小田義直
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 充実型低分化腺癌におけるミスマッチ修復蛋白とSWI/SNF複合体の欠失 (2019)
  • Author(s): 鶴田伸一、孝橋賢一、山田裕一、藤原美奈子、古賀裕、小田義直
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 未分化多形肉腫におけるPD-L1とIDO-1の発現の検討 (2019)
  • Author(s): 石原新、山田裕一、岩崎健、伊東良広、戸田雄、吉本昌人、孝橋賢一、山元英崇、藤原稔史、中島康晴、薛宇孝、遠藤誠、松本嘉寛、中島康晴、小田義直
  • Organizer: 第52回日本整形外科学会骨軟部腫瘍学術総会
• [Presentation] 骨肉腫におけるPDL1とIDO1の発現 (2019)
  • Author(s): 戸田雄、孝橋賢一、山田裕一、吉本昌人、石原新、伊東良広、岩崎健、山元英崇、藤原稔史、
  • Organizer: 第52回日本整形外科学会骨軟部腫瘍学術総会
• [Presentation] 後腹膜脂肪肉腫の組織診断とその鑑別 (2019)
  • Author(s): 孝橋賢一、山元英崇、山田裕一、木下伊寿美、小田義直
  • Organizer: 第52回日本整形外科学会骨軟部腫瘍学術総会
  • Invited
• [Presentation] Diagnostic utility of pan-TRK immunohistochemistry in inflammatory myofibroblastic tumor (2019)
  • Author(s): Yamamoto H, Nozaki Y, Kohashi K, Oda Y
  • Organizer: 108th Annual Meeting of USCAP
  • Int'l Joint Research
• [Presentation] Prognostic impact of the MDM2/HMGA2 ratio and clinicopathological factors in well-differentiated and dedifferentiated liposarcoma (2019)
  • Author(s): Yamashita K, Kohashi K, Yamada Y, Akatsuka S, Oda Y
  • Organizer: 108th Annual Meeting of USCAP
  • Int'l Joint Research
• [Presentation] 脾臓低形成例に発症した肺炎球菌によるWaterhouse-Friderichsen症候群の一剖検例 (2018)
  • Author(s): 北原大地,畑中優衣、松下能文、孝橋賢一、新屋剛広、竹内宏樹、山本一視、小田義直
  • Organizer: 日本病理学会総会
• [Presentation] 乳児線維症から横紋筋肉腫へ悪性転化を来した一例 (2018)
  • Author(s): 木下伊寿美、山田裕一、孝橋賢一、山元英崇、小田義直
  • Organizer: 日本病理学会総会
• [Presentation] HidradenomaにおけるCRTC1/3-MAML2融合遺伝子の発現と臨床病理学的検討 (2018)
  • Author(s): 隈有希、山田裕一、山元英崇、孝橋賢一、伊東孝通、古江増隆、小田義直
  • Organizer: 日本病理学会総会
• [Presentation] 横紋筋肉腫におけるがん精巣抗原MPHOSPH1発現の検討 (2018)
  • Author(s): 武本淳吉、孝橋賢一、渋井勇一、阿部立郎、木下伊寿美、山田裕一、山元英崇、田口智章、小田義直
  • Organizer: 日本病理学会総会
• [Presentation] SMARRCB1/INI1陽性類上皮肉腫におけるSWI/SNF複合体関連蛋白発現 (2018)
  • Author(s): 孝橋賢一、山元英崇、山田裕一、木下伊寿美
  • Organizer: 日本整形外科学会 骨軟部腫瘍学術集会
• [Presentation] 画像初見と病理所見が乖離した脛骨骨肉腫の１例 (2018)
  • Author(s): 戸田雄、孝橋賢一、石原新、吉本昌人、大塚 洋、山田裕一、山元英崇、田口健一、横山良平、小田義直
  • Organizer: 日本整形外科学会 骨軟部腫瘍学術集会
• [Presentation] 胎児肝細胞組織が遺残した肝間葉性過誤腫の一例 (2018)
  • Author(s): 渋井勇一、宗﨑良太、木下義晶、鴨打周、武本淳吉、孝橋賢一、松浦俊治、小田義直、田口智章
  • Organizer: 小児血液がん学会
• [Presentation] 長期生存している悪性ラブドイド腫瘍の1例 (2018)
  • Author(s): 三島泰彦、孝橋賢一、渋井勇一、武本淳吉、宗﨑良太、小田義直、田口智章
  • Organizer: 小児血液がん学会
• [Presentation] 中枢神経原発悪性黒色腫に対してNivolumabを使用した小児例 (2018)
  • Author(s): 大場詩子、古賀友紀、川口理一郎、中島健太郎、石村匡崇、赤木洋二郎、秦暢宏、吉本幸司、孝橋賢一、飯原弘二、小田義直、大賀正一
  • Organizer: 小児血液がん学会
• [Presentation] 感染による敗血症性ショックをきたした巨大リンパ管奇形の1例 (2018)
  • Author(s): 宗﨑良太、吉田聖、武本淳吉、渋井勇一、孝橋賢一、小田義直、田口智章
  • Organizer: 小児血液がん学会
• [Presentation] 12.ロボット支援腎部分切除術を施行した学童後期のWilms腫瘍男児例 (2018)
  • Author(s): 渋井勇一、宗崎良太、木下義晶、宮嵜航、武本淳吉、川久保尚徳、孝橋賢一、江上直樹、大場詩子、古賀友紀、波止亮、猪口淳一、小田義直、大賀正一、江藤正俊
  • Organizer: 小児外科学会学術集会
• [Presentation] 骨軟部腫瘍の遺伝子解析と病理診断への応用 上皮様軟部腫瘍の鑑別診断と遺伝子異常 (2018)
  • Author(s): 孝橋賢一、山元英崇、山田裕一、木下伊寿美、小田義直
  • Organizer: 日本病理学会総会
  • Invited
• [Presentation] 多機能な細胞接着分子が関わるがんの理解－診断・治療への応用をめざして：軟部腫瘍における接着分子の発現 (2018)
  • Author(s): 山元英崇、孝橋賢一、齋藤剛、小田義直
  • Organizer: 日本病理学会総会
  • Invited
• [Presentation] 形態学的、分子生物学的アプローチによる小児固形腫瘍の病理診断：小児上皮様軟部腫瘍の鑑別診断 (2018)
  • Author(s): 孝橋賢一、山元英崇、山田裕一、木下伊寿美、小田義直
  • Organizer: 小児血液がん学会
  • Invited
• [Presentation] Diagnostic utility of pan-TRK immunohistochemistry in inflammatory myofibroblastic tumor (2018)
  • Author(s): Hidetaka Yamamoto, Yui Nozaki, Kenichi Kohashi, Yoshinao Oda
  • Organizer: Annual Meeting of the United States and Canadian Academy of Pathology
  • Int'l Joint Research
• [Presentation] Brachyury expression in SMARCB1/INI1-deficient tumors (2018)
  • Author(s): K Kohashi, H Yamamoto, Y Yamada, Y Oda
  • Organizer: United States and Canadian Academy of Pathology Annual Meeting
• [Presentation] 小児軟部腫瘍における病理診断の進め方 (2017)
  • Author(s): 孝橋賢一、木下伊寿美、小田義直
  • Organizer: 日本病理学会総会
• [Presentation] SMARCB1/INI1-deficient tumorの鑑別診断 (2017)
  • Author(s): 孝橋賢一、山元英崇、山田裕一、木下伊寿美、小田義直
  • Organizer: 日本整形外科学会 骨軟部腫瘍学術集会
• [Presentation] 骨軟部腫瘍の病理組織分類の現状と基盤となる遺伝子異常 (2017)
  • Author(s): 孝橋賢一、山元英崇、山田裕一、木下伊寿美、小田義直
  • Organizer: 日本臨床細胞学会