| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The location and the function of disulfide bond in occludin, a transmembrane protein in tight junction, was investigated. A disulfide bond in extracellular loop of occludin affects its stability under hypoxia via HIF-1 and its ubiquitination. Occludin affects cell proliferation and apoptosis via its ubiquitination. Cysteines in intracytoplasmic tail of occludin may be involved in cell signaling due to its high activity. Also 3 cysteines in transmembrane lesion of occludin form disulfide bond.
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