cell cell interaction with macrophages and lymphoma

• Project/Area Number: 17K08763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kumamoto University
• Principal Investigator: horlad hasita 熊本大学, 大学院生命科学研究部(医), 研究員 (00644840)
• Co-Investigator(Kenkyū-buntansha): 菰原 義弘 熊本大学, 大学院生命科学研究部(医), 准教授 (40449921)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: マクロファージ / CADM1 / リンパ腫 / 細胞間相互作用

Outline of Final Research Achievements

We clarified the importance of macrophages in various malignant tumors such as lymphoma. The expression of PD-L1 and CD163 in macrophages was increased by a cancer cell-derived factor, and it was revealed that these molecules contribute to tumor development.

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍におけるマクロファージの役割を明らかにすることで、マクロファージを標的にした新しい治療法の開発につながることができる。

Research Products

• [Journal Article] Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment (2020)
  • Author(s): Pan Cheng、Fujiwara Yukio、Horlad Hasita、Shiraishi Daisuke、Iriki Toyohisa、Tsuboki Jyunko、Ikeda Tsuyoshi、Komohara Yoshihiro
  • Journal Title: Frontiers in Pharmacology Volume: 11 Pages: 00262-00262
  • DOI: 10.3389/fphar.2020.00262
  • Peer Reviewed / Open Access
• [Journal Article] Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma (2018)
  • Author(s): Yoshihiro Komohara,1,2) Osamu Noyori,3) Yoichi Saito,1) Hiroto Takeya,1) Muhammad Baghdadi,4) Fumihito Kitagawa,4) Naoki Hama,4) Kozo Ishikawa,4) Yutaka Okuno,5) Kisato Nosaka,5) Ken-ichiro Seino,4) Masao Matsuoka,5) and Shinya Suzu3)
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 58 Issue: 4 Pages: 152-160
  • DOI: 10.3960/jslrt.18034
  • NAID: 130007529824
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Journal Article] CD163 is required for protumoral activation of macrophages in human and murine sarcoma. (2018)
  • Author(s): Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
  • Journal Title: Cancer Res Volume: in press Issue: 12 Pages: 3255-3266
  • DOI: 10.1158/0008-5472.can-17-2011
  • Peer Reviewed
• [Journal Article] Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages. (2017)
  • Author(s): Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 57 Issue: 1 Pages: 15-20
  • DOI: 10.3960/jslrt.17003
  • NAID: 130005709559
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Journal Article] Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines (2017)
  • Author(s): Ma C, Horlad H, Pan C, Yano H, Ohnishi K, Fujiwara Y, Matsuoka M, Lee A, Niidome T, Yamanaka R, Takeya M, Komohara Y
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 57 Issue: 1 Pages: 21-25
  • DOI: 10.3960/jslrt.17006
  • NAID: 130005709510
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] M2-likeマーカーであるCD163はマクロファージの腫瘍促進性活性化に関与する (2018)
  • Author(s): 菰原義弘、白石大偉輔、西東洋一、Horlad Hasita、藤原章雄
  • Organizer: 第22回 日本がん免疫学会総会
• [Presentation] 悪性リンパ腫ではコレステロール代謝経路が治療標的になりうる. (2017)
  • Author(s): Horlad Hasita,藤原章雄、新野大輔、菊川吉高、奥野豊、松岡雅夫、竹屋元裕、菰原義弘
  • Organizer: 第106回 日本病理学会総会
• [Presentation] B細胞性リンパ腫におけるIL-34の重要性. (2017)
  • Author(s): 菰原義弘、馬超亜、潘 程、Carreras Joaquim、中村直哉、竹屋元裕
  • Organizer: 第57回 日本リンパ網内系学会