cell cell interaction with macrophages and lymphoma
Project/Area Number |
17K08763
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Kumamoto University |
Principal Investigator |
horlad hasita 熊本大学, 大学院生命科学研究部(医), 研究員 (00644840)
|
Co-Investigator(Kenkyū-buntansha) |
菰原 義弘 熊本大学, 大学院生命科学研究部(医), 准教授 (40449921)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | マクロファージ / CADM1 / リンパ腫 / 細胞間相互作用 |
Outline of Final Research Achievements |
We clarified the importance of macrophages in various malignant tumors such as lymphoma. The expression of PD-L1 and CD163 in macrophages was increased by a cancer cell-derived factor, and it was revealed that these molecules contribute to tumor development.
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Academic Significance and Societal Importance of the Research Achievements |
悪性腫瘍におけるマクロファージの役割を明らかにすることで、マクロファージを標的にした新しい治療法の開発につながることができる。
|
Report
(4 results)
Research Products
(8 results)
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[Journal Article] Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma2018
Author(s)
Yoshihiro Komohara,1,2) Osamu Noyori,3) Yoichi Saito,1) Hiroto Takeya,1) Muhammad Baghdadi,4) Fumihito Kitagawa,4) Naoki Hama,4) Kozo Ishikawa,4) Yutaka Okuno,5) Kisato Nosaka,5) Ken-ichiro Seino,4) Masao Matsuoka,5) and Shinya Suzu3)
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Journal Title
Journal of Clinical and Experimental Hematopathology
Volume: 58
Issue: 4
Pages: 152-160
DOI
NAID
ISSN
1346-4280, 1880-9952
Related Report
Peer Reviewed / Open Access
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[Journal Article] CD163 is required for protumoral activation of macrophages in human and murine sarcoma.2018
Author(s)
Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
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Journal Title
Cancer Res
Volume: in press
Issue: 12
Pages: 3255-3266
DOI
Related Report
Peer Reviewed
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[Journal Article] Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages.2017
Author(s)
Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M
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Journal Title
Journal of Clinical and Experimental Hematopathology
Volume: 57
Issue: 1
Pages: 15-20
DOI
NAID
ISSN
1346-4280, 1880-9952
Related Report
Peer Reviewed / Open Access
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[Journal Article] Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines2017
Author(s)
Ma C, Horlad H, Pan C, Yano H, Ohnishi K, Fujiwara Y, Matsuoka M, Lee A, Niidome T, Yamanaka R, Takeya M, Komohara Y
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Journal Title
Journal of Clinical and Experimental Hematopathology
Volume: 57
Issue: 1
Pages: 21-25
DOI
NAID
ISSN
1346-4280, 1880-9952
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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