| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
It is thought that pancreatic cancer cells release various factors that develop the surrounding environment and contribute to tumor malignancy. We established genetically engineered animal models for human pancreatic ductal adenocarcinoma that can develop in a short period. In our rat pancreatic cancer model, we identified some genes that are highly expressed. In addition, we identified transcription factors that regulate gene expression of these genes. The cytokines released from the stroma activate the transcription factors, which in turn upregulate the expression of various target genes and are thought to be involved in the progression of pancreatic cancer through cancer-stromal interactions.
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