| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Nonalcoholic steatohepatitis (NASH) is a fatal disease caused by the accumulation of fat, mainly triglycerides, in hepatocytes, resulting in inflammation and fibrosis. In the present study, we analyzed the pathogenesis of NASH in spontaneously developing p62 and Nrf2 double-deleted (DKO) mice. The results showed that the increased percentage of gram-negative bacteria in DKO mice compared to wild-type mice, high levels of inflammatory metabolites in the feces, decreased intestinal barrier function, and decreased phagocytosis of hepatic kupffer cells were deeply involved in the disease. It was suggested that Nrf2 deficiency was a major factor in these causes.
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