| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
P-bodies (PBs) are cytoplasmic messenger ribonucleoprotein (mRNP) granules mainly composed of mRNAs and proteins involved in translation repression and mRNA decay. To elucidate the role of PBs, which are formed in the early stages of infection with a protozoan parasite Trypanosoma cruzi (T. cruzi), in regulating host mRNA metabolism, we analyzed the impact of PB depletion on host transcriptome during T. cruzi infection. The results indicated that the expression of inflammatory cytokines and activation of innate immune-related signaling pathways were enhanced in PB-defective cells compared to wild-type cells. Our results show for the first time that T. cruzi may establish infection by negatively regulating the host innate immune response through the promotion of PB assembly.
|
