| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Apolipoprotein E (apoE) is a 34 kDa glycoprotein and its role on lipid metabolism is a ligand for lipoprotein receptor on the liver. We created apoE-deficient model using rabbits, which have more similar lipoprotein metabolism to humans than mice. To investigate the role of apoE in lipoprotein metabolism and atherosclerosis, we analyzed plasma lipids, lipoproteins and susceptibility to a diet-induced atherosclerosis of apoE-deficient rabbits. ApoE-deficent rabbits showed higher plasma total cholesterol and triglycerides levels than those of wild-type rabbits on a high cholesterol-diet. This increase was due to an elevated plasma βVLDL, and the βVLDL showed enriched apoB-48. Our studies revealed that deficiency of apoE in rabbits promotes aortic atherosclerosis.
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