Elucidation of new mechanism of blood-brain barrier breakdown due to cerebral cytomegalovirus infection and search for treatment method
| Project/Area Number |
17K08784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Kawasaki Hideya 浜松医科大学, 光尖端医学教育研究センター, 准教授 (90397381)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | サイトメガロウイルス / 血液脳関門 / 微粒子 / ナノスーツ / ナノスーツ法 / ナノ粒子 |
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| Outline of Final Research Achievements |
After birth, healthy people rarely cause serious health problems due to CMV, but in recent years, the relationship between CMV antibody carriers and dementia has begun to attract attention. The detailed mechanism is unknown, but the relationship with CMV persistent infection has been pointed out. There are many reports that BBB failure is involved in the onset of dementia, and it is highly possible that CMV-induced BBB failure is a mechanism for the progression of dementia. Currently, little research has been conducted on the mechanism of BBB failure by CMV, and this application is considered to be positioned as important research in Japan and overseas, and we have proceeded with this research. The influence of the corona and the creation of the experimental model did not go well, and it was not possible to proceed as originally planned.
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| Academic Significance and Societal Importance of the Research Achievements |
われわれはCMV急性感染におけるin vivoでのBBB破綻現象を観察したが、未だCMV慢性持続感染によってin vivo BBB破綻現象を確認したという報告はない。本研究でその現象が確認されれば、CMV慢性持続感染による認知症を含めた変性疾患の新しい病理機序の説明をすることができる。またCMV感染のCyPA-MMP活性化経路によるBBB破綻機序が解明されれば、そこをtargetにした新しい治療につながると考えた。コロナの影響や実験モデルの作成がうまくいかず、当初の計画通りは進むことができなかった。
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Report
(6 results)
Research Products
(53 results)
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[Journal Article] Metformin reduces pleural fibroelastosis by inhibition of extracellular matrix production induced by CD90-positive myofibroblasts.2021
Author(s)
Aoshima Yoichiro,Enomoto Yasunori,Fukada Atsuki,Kurita Yuki,Matsushima Sayomi,Meguro Shiori,Kosugi Isao,Kawasaki Hideya,Katsura Hiroaki,Fujisawa Tomoyuki,Enomoto Noriyuki,Nakamura Yutaro,Inui Naoki,Suda Takafumi,Iwashita Toshihide
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Journal Title
American journal of translational research
Volume: 13
Pages: 12318-12337
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation2021
Author(s)
Shinmura K, Kusafuka K, Kawasaki H, Kato H, Hariyama T, Tsuchiya K, Kawanishi Y, Funai K, Misawa K, Mineta H, Sugimura H
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Journal Title
Journal of Pathology
Volume: -
Issue: 5
Pages: 519-530
DOI
Related Report
Peer Reviewed
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[Journal Article] Podoplanin-positive myofibroblasts: a pathological hallmark of pleuroparenchymal fibroelastosis.2018
Author(s)
Enomoto Y, Matsushima S, Meguro S, Kawasaki H, Kosugi I, Fujisawa T, Enomoto N, Inui N, Nakamura Y, Suda T, Iwashita T.
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Journal Title
Histopathology.
Volume: 印刷中
Issue: 7
Pages: 1209-1215
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phenotypic characterization of perivascular myoid cell neoplasms, using myosin 1B, a newly identified human pericyte marker2017
Author(s)
Shiori Meguro, Taisuke Akamatsu, Sayomi Matsushima, Isao Kosugi, Hideya Kawasaki, Yoshifumi Arai, Satoshi Baba, Takashi Tsuchida, Yoji Shido, Takafumi Suda, Toshihide Iwashita
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Journal Title
Human Pathology
Volume: 62
Pages: 187-198
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Evaluation of epigenetic inactivation of vascular endothelial growth factor receptors in head and neck squamous cell carcinoma.2017
Author(s)
Misawa Y, Misawa K, Kawasaki H, Imai A, Mochizuki D, Ishikawa R, Endo S, Mima M, Kanazawa T, Iwashita T, Mineta H.
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Journal Title
Tumour Biol.
Volume: 39
Issue: 7
Pages: 1-15
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A modified ‘NanoSuit’ preserves wet samples in high vacuum: direct observations on cells and tissues in field-emission scanning electron microscopy.2017
Author(s)
Takaku Y, Suzuki H, Kawasaki H, Ohta I, Ishii D, Hirakawa S, Tsutsui T, Matsumoto H, Takehara S, Nakane C, Sakaida K, Suzuki C, Muranaka Y, Kikuchi H, Konno H, Shimomura M, Hariyama T
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Journal Title
R Soc Open Sci
Volume: なし
Issue: 3
Pages: 160887-160887
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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