| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is well understood that the protein ubiquitin modification system is involved in diseases development such as infectious diseases, cancer, and neurodegenerative diseases. However, the significance of ubiquitin system in bacterial infection remains largely unknown. In this study, we elucidated the role of the ubiquitin modification system in the pathogenic bacteria infection using structural, biochemical, and pathological approaches. We found that ubiquitin is modified under the bacterial infection and modulated host immune signaling. Based on our results, we will plan to develop new therapeutic tools against pathogenic bacteria infection.
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