| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Dysregulation of leptin receptor (LepR) signaling links to development of gastric tumors. In this study, we demonstrated that LepR signaling activation is essential for the induction of gastric tumor, intestinal metaplasia and dysbiosis of microbiota using both models of gene-targeting and high-fat diet-induced obese mice. LepR-deletion suppresses the development of these pathogenesis and dysbiosis. These results indicate that the gastric leptin signaling can regulate cell differentiation of the stomach and environment of gastric mucosa.
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