| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To analyze the adaptive immune response to highly pathogenic avian influenza (HPAI) H5N1 virus infection that causes severe pneumonia, we compared the pathogenesis and induction of antigen-specific antibodies in mice and cynomolgus macaques infected with seasonal H1N1 or HPAI H5N1 viruses.
In HPAI H5N1 virus-infected animals, the interaction between dendritic cells and CD4+ T cells was more sparse and antibody induction was much weaker than in H1N1-infected animals. It was considered that the severity of HPAI H5N1 virus infection was due to abnormal dendritic cell activation and accumulation, and subsequent failure of T cells to activate B cells and reduce antibody production. In contrast, prophylactic vaccination induced potent antibody production and prevented severe disease caused by HPAI H5N1 virus infection.
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