| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Lymphocyte-specific adaptor protein, Lnk (also known as Sh2b3), is primarily expressed in hematopoietic cells where it functions as a negative regulator of cytokine signaling and cell proliferation. Single nucleotide polymorphisms in Lnk are associated with autoimmune and cardiovascular disorders, but the mechanism by which Lnk contributes to those diseases is unknown. We found that Lnk-/- mice showed glucose intolerance and insulin resistance, and the expansion and activation of group 1-innate lymphoid cells (G1-ILCs) in adipose tissues. The results delineate a primary mechanism by which Lnk/Sh2b3 regulates homeostatic processes in adipose tissues and also how it affects the risk of diabetes by regulating the expansion and activation of adipose G1-ILCs and their contribution to insulin resistance.
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