| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Thymic Stromal LymphoPoietin (TSLP) is an important mediator for the development of Th2-type allergic diseases, including atopic dermatitis (AD), in both human patients and murine models. However, the physiological role of TSLPR signaling by CD4 T cells in the development of skin inflammation by chronic allergen exposure remains to be elucidated. To investigate the role of TSLP in the progression of allergic inflammation, we used Tslpr conditional KO mice and a newly developed skin chronic inflammation model that features repetitive allergen challenge. In this study, we demonstrated that TSLPR on CD4 T cells is critical for development of chronic skin inflammation through enhancing IL-4 production and inhibiting cell death.
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