Development of advanced pseud-parasite with self-assembly-nanoparts (SNAP) for subunit vaccines
| Project/Area Number |
17K08810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kagoshima University |
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Principal Investigator |
Miyata Takeshi 鹿児島大学, 農水産獣医学域農学系, 准教授 (20448591)
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| Co-Investigator(Kenkyū-buntansha) |
門川 淳一 鹿児島大学, 理工学域工学系, 教授 (30241722)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マラリア / ナノパーツ / ワクチン / 自己集合 / 感染防御・制御 / プラットフォーム / ナノ粒子 |
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| Outline of Final Research Achievements |
We have been developing subunit vaccines based on recombinant protein antigens using several self-nanoassembley-parts(SNAPs). In detail, a mesh-like molecule produced by modifying a branched-chain to the antigen showed a remarkable enhancement of the antibody production response in animal experiments. To put this technology to practical use, we are working on the optimization of the method of production.
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| Academic Significance and Societal Importance of the Research Achievements |
本技術は、人獣共通感染症に対するワクチンの開発に資するものであり、2020年現在、人類が直面している未曾有の感染症危機に対する解決策として、重要な技術の基礎を造るものである。ワクチンは最小の費用で、最大の効果を生み出す感染症対策に重要な技術であるが、病原体ごとに適切なワクチン開発を進める必要もあり、実用化に向けた多くの有効でかつ多様な戦略を推し進めることが重要である。
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Evaluation of vaccine potential of 2-Cys peroxiredoxin from the hard tick Haemaphysalis longicornis2018
Author(s)
Kusakisako, K., Miyata, T., Tsujio, M., Galay, R. L., Talactac, M. R., Hernandez, E. P., Fujisaki, K. and Tanaka, T.
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Journal Title
Exp. Appl. Acarol.
Volume: 74 (1)
Issue: 1
Pages: 73-84
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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