| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus has been shown to suppress autophagy. Regarding this activity, details in mechanism and a role TSST-1 on chronic skin infection of S. aureus were studied. TSST-1 expression was temperature-dependently regulated by SarAB system. The autophagy suppression mechanism of this toxin was suggested to be mediated by a small GTPase, Septin 7. Live-imaging demonstrated that TSST-1 promotes bacterial number of S. aureus in the epithelial cells. Skin infection in mouse model showed that TSST-1 promotes tissue damage and invasion of S. aureus in the deep dermis layer. These results suggested that TSST-1 may involve in the persistence of S. aureus in the host cells and promote chronic skin infection.
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