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Discrimination of multi-drug resistant bacteria by machine learning.

Research Project

Project/Area Number 17K08827
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including mycology)
Research InstitutionOsaka University

Principal Investigator

Nishino Mitsuko  大阪大学, 産業科学研究所, 助教 (30510440)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords多剤耐性菌 / 電子顕微鏡 / 機械学習 / 細菌
Outline of Final Research Achievements

The emergence of multidrug-resistant bacteria is a global problem of today, and overcoming infectious diseases is one of the important medical issues. There is an urgent need to develop a method for suppressing the emergence of resistant bacteria, and a rapid detection method is required. The purpose of this study is to establish the image discrimination method of resistant bacteria using machine learning, paying attention to the morphological changes occurring in the process of multidrug resistance of bacteria.
As a result of working on the development of machine learning discrimination of electron microscope images using enoxacin resistant strains, we succeeded in image discrimination with accuracy of 90%. Furthermore, we succeeded in extracting and visualizing the structural features of resistant bacteria.

Academic Significance and Societal Importance of the Research Achievements

多剤耐性菌による感染症は世界的な問題であり、医療現場において耐性菌の出現を予測し感染拡大防止を講じる対策法の開発が重要な課題となっている。本研究は人工知能による画像識別法を用いて薬剤耐性菌の自動判別を行う学習アルゴリズムの構築に成功した。この成果により、多剤耐性化プロセスで生じる形態の変化から耐性菌の出現を予測し、院内感染拡大予防に役立つ情報基盤が提供できると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2019 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] The Golgin Protein Giantin Regulates Interconnections Between Golgi Stacks2019

    • Author(s)
      Satoh Ayano、Hayashi-Nishino Mitsuko、Shakuno Takuto、Masuda Junko、Koreishi Mayuko、Murakami Runa、Nakamura Yoshimasa、Nakamura Toshiyuki、Abe-Kanoh Naomi、Honjo Yasuko、Malsam Joerg、Yu Sidney、Nishino Kunihiko
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 7 Pages: 160-160

    • DOI

      10.3389/fcell.2019.00160

    • NAID

      120006733903

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 電子顕微鏡画像における薬剤耐性菌株の識別と形態的特徴の比較2019

    • Author(s)
      長野章宏、青木工太、西野美都子、福島愛子、岩崎憲治、古澤力、アンドレイ グルシニコフ、越後富夫、西野邦彦、八木康史
    • Organizer
      第215回情報処理学会コンピュータビジョンとイメージメディア研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] ゴルジンタンパク質であるGiantinはゴルジ体ゾーンの形成に関与するか?2018

    • Author(s)
      佐藤あやの、杓野拓斗、西野-林美都子、西野邦彦
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] A 3D modeling of Golgi stacks in giantin knockdown cells.2018

    • Author(s)
      Takuto Shakuno, Mitsuko Hayashi-Nishino, Kunihiko Nishino and Ayano Satoh
    • Organizer
      第70回日本細胞生物学会・第51回日本発生生物学会合同大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Characterization of the novel inhibitor for protein secretion.2018

    • Author(s)
      Ayano Satoh, Hideyuki Suzuki, Mitsuko Hayashi-Nishino, Kunihiko Nishino and Yuta Nishina
    • Organizer
      第70回日本細胞生物学会・第51回日本発生生物学会合同大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 畳み込みニューラルネットワークを用いた電子顕微鏡像における薬剤耐性菌の識別2018

    • Author(s)
      長野章宏、青木工太、武内優奈、西野美都子、西野邦彦、古澤力、岩崎憲治、越後富夫、八木康史
    • Organizer
      第207回CVIM研究発表会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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