• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Regulation of sepsis by alarmin that induces the release of ectosomes with antibacterial potential from neutrophils

Research Project

Project/Area Number 17K08840
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including mycology)
Research InstitutionJuntendo University

Principal Investigator

Nagaoka Isao  順天堂大学, 保健医療学部, 特任教授 (60164399)

Co-Investigator(Kenkyū-buntansha) 桑原 京子  順天堂大学, 医学部, 非常勤講師 (10167976)
射場 敏明  順天堂大学, 医学部, 教授 (40193635)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords好中球 / エクトソーム / 敗血症 / 抗菌ペプチド / LL-37 / 細胞外小胞 / アラーミン / 生体防御ペプチド / エクソソーム / ectosome / alarmin / cathelicidin / microparticle
Outline of Final Research Achievements

Neutrophils release microvesicles (ectosomes) upon stimulation. Interestingly, ectosome level is elevated in sepsis survivors. Previously, we revealed that LL-37, an antimicrobial peptide, improves the survival of septic mice. In the present study, we elucidated the action of LL-37 on septic mice, by focusing on the release of ectosomes from neutrophils. The results revealed that the ectosome level was enhanced by LL-37-administration, accompanied with reduced bacterial load. Importantly, ectosomes from LL-37-injected septic mice contained antimicrobial proteins/peptides, suggesting that LL-37 induces the release of antibacterial ectosomes. In fact, LL-37 stimulated mouse neutrophils to release antibacterial ectosomes. Furthermore, the administration of ectosomes reduced the bacterial load and improved the survival of septic mice. These observations suggest that LL-37 induces the release of antibacterial ectosomes, thereby reducing the bacterial load and protecting mice from sepsis.

Academic Significance and Societal Importance of the Research Achievements

エクトソームは、敗血症において増加し、宿主細胞機能を変調させることから、敗血症治療の新たな標的として近年注目されている。申請者は、これまで、生体内抗菌ペプチドであるLL-37の宿主細胞に対する作用を解明してきたが、今回、LL-37が好中球を刺激して、抗菌活性をもつエクトソームの放出することで敗血症の病態改善に関与することを明らかにした。本研究の成果は、新たな視点で、生体内抗菌ペプチドの働きを解明したばかりでなく、将来、抗菌ペプチドを用いた安全かつ有効な敗血症治療法を開発するために有用な情報を提供するという点において意義深いと考える。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (93 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (7 results) Journal Article (31 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 31 results,  Open Access: 27 results) Presentation (42 results) (of which Int'l Joint Research: 9 results,  Invited: 17 results) Book (10 results) Remarks (3 results)

  • [Int'l Joint Research] Microcoat Biotechnologie GmbH(ドイツ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Microcoat Biotechnologie GmbH(ドイツ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Microcoat Biotechnologie GmbH(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Microcoat Biotechnologie GmbH(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Duke University(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Microcoat Biotechnologie GmbH(ドイツ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Manchester Royal Infirmary(英国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells2021

    • Author(s)
      Mijiti N, Someya A, Nagaoka I
    • Journal Title

      Exp Ther Med

      Volume: 22 Issue: 5 Pages: 1300-1300

    • DOI

      10.3892/etm.2021.10735

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] タマネギ外皮を摂取したマウス脳におけるMAO-A 酵素活性とセロトニン濃度への影響2021

    • Author(s)
      井上節子, 高野夏希, 神林美樹, 中島 滋, 長岡 功
    • Journal Title

      日本未病学会雑誌

      Volume: 27 Pages: 14-20

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] タマネギ外皮添加レシピの抗酸化力に与える調理方法と食品成分の影響2021

    • Author(s)
      井上節子, 岩井 達,戸田和正, 高尾茉帆, 嵐 雅子, 長岡 功
    • Journal Title

      Functional Food Research

      Volume: 17 Pages: 126-133

    • NAID

      130008145174

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outstanding contributions of LAL technology to pharmaceutical and medical science: Review of methods, progress, challenges, and future perspectives in early detection and management of bacterial infections and invasive fungal diseases2021

    • Author(s)
      Tamura H, Reich J, Nagaoka I
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 5 Pages: 536-536

    • DOI

      10.3390/biomedicines9050536

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recent advances in the research and management of sepsis-associated DIC2021

    • Author(s)
      Iba T, Connors JM, Nagaoka I, Levy JH
    • Journal Title

      Int J Hematol

      Volume: 113 Issue: 1 Pages: 24-33

    • DOI

      10.1007/s12185-020-03053-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] II型コラーゲンとI型コラーゲンに対するバイオマーカーを用いた、各種運動競技選手における軟骨・骨 代謝の評価2021

    • Author(s)
      長岡 功, 吉村雅文
    • Journal Title

      日本未病学会雑誌

      Volume: 27 Pages: 74-77

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 機能性食品であるグルコサミンの関節保護作用の分子メカニズム2021

    • Author(s)
      長岡 功
    • Journal Title

      順天堂保健医療学雑誌

      Volume: 2 Pages: 2-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newly developed recombinant antithrombin protects the endothelial glycocalyx in an endotoxin-induced rat model of sepsis2020

    • Author(s)
      Iba T, Levy JH, Aihara K, Kadota K, Tanaka H, Sato K, Nagaoka I
    • Journal Title

      Int J Mol Sci

      Volume: 22 Issue: 1 Pages: 176-176

    • DOI

      10.3390/ijms22010176

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Yokukansan, a Japanese Herbal Medicine, Suppresses Substance P-induced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells2020

    • Author(s)
      Yamaguchi K, Yamazaki S, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I
    • Journal Title

      Endocr Metab Immune Disord Drug Targets

      Volume: - Issue: 7 Pages: 1073-1080

    • DOI

      10.2174/1871530320666200131103733

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine2020

    • Author(s)
      Yamagishi Y, Someya A, Nagaoka I
    • Journal Title

      Biomed Rep

      Volume: 13 Issue: 1 Pages: 37-42

    • DOI

      10.3892/br.2020.1304

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils2020

    • Author(s)
      Kumagai Y, Murakami T, Kuwahara-Arai, Iba T, Reich J, Nagaoka I
    • Journal Title

      Innate Immun

      Volume: 26 Issue: 7 Pages: 565-579

    • DOI

      10.1177/1753425920936754

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic potential of cathelicidin peptide LL-37, an antimicrobial agent, in a murine sepsis model2020

    • Author(s)
      Nagaoka I, Tamura H, Reich J
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 17 Pages: 5973-5973

    • DOI

      10.3390/ijms21175973

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic Action of Antimicrobial Cathelicidin Peptide LL-37 on a Murine Sepsis Model2020

    • Author(s)
      Nagaoka I, Hu Z, Hosoda H, Kumagai Y
    • Journal Title

      Juntendo Medical Journal

      Volume: 66 Issue: 4 Pages: 297-311

    • DOI

      10.14789/jmj.2020.66.JMJ20-R08

    • NAID

      130007893567

    • ISSN
      2187-9737, 2188-2126
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the 5-fluorouracil Plasma Level in Patients With Colorectal Cancer Undergoing Continuous Infusion Chemotherapy2019

    • Author(s)
      Abe Y, Sakuyama N, Sato T, Kishine K, Nagayasu K, Nakatani A, Kitajima M, Watanabe T, Nishimura K, Ochiai T, Nagaoka I
    • Journal Title

      Mol Clin Oncol ,

      Volume: 11 Pages: 289-295

    • DOI

      10.3892/mco.2019.1893

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bacterial Lipopolysaccharide and Antimicrobial LL-37 Enhance ICAM-1 Expression and NF-κB p65 Phosphorylation in Senescent Endothelial Cells2019

    • Author(s)
      Suzuki K, Ohkuma M, Nagaoka I
    • Journal Title

      Int J Mol Med

      Volume: 44 Pages: 1187-1196

    • DOI

      10.3892/ijmm.2019.4294

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Potential Use of Grape Phytochemicals for Preventing the Development of Intestine-Related and Subsequent Inflammatory Diseases2019

    • Author(s)
      Santa K, Kumazawa Y, Nagaoka I
    • Journal Title

      Endocr Metab Immune Disord Drug Targets

      Volume: 19 Issue: 6 Pages: 794-802

    • DOI

      10.2174/1871530319666190529105226

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Aging on the Tendon Structure and Tendon-Associated Gene Expression in Mouse Foot Flexor Tendon2019

    • Author(s)
      Sugiyama Y, Naito K, Goto K, Kojima Y, Furuhata A, Igarashi M, Nagaoka I, Kaneko K
    • Journal Title

      Biomed Rep

      Volume: 10 Pages: 238-244

    • DOI

      10.3892/br.2019.1200

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chondroprotective Action of Glucosamine, a Chitosan Monomer, on the Joint Health of Athletes2019

    • Author(s)
      Nagaoka I, Tsuruta A, Yoshimura M
    • Journal Title

      Int J Biol Macromol

      Volume: 132 Pages: 795-800

    • DOI

      10.1016/j.ijbiomac.2019.03.234

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cartilage Metabolism in Endurance Athletes and Chondroprotective Action of Glucosamine2019

    • Author(s)
      Nagaoka I
    • Journal Title

      Juntendo Medical Journal

      Volume: 65 Issue: 2 Pages: 184-193

    • DOI

      10.14789/jmj.2019.65.JMJ19-LN01

    • NAID

      130007670504

    • ISSN
      2187-9737, 2188-2126
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low Endotoxin Recovery-Masking of Naturally Occurring Endotoxin.2019

    • Author(s)
      Reich J, Weyer FA, Tamura H, Nagaoka I, Motschmann H
    • Journal Title

      Int J Mol Sci

      Volume: 20 Issue: 4 Pages: 838-838

    • DOI

      10.3390/ijms20040838

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of primary tumor location as a predictive factor in patients suffering from colorectal cancer treated with cytotoxic anticancer agents based on the collagen gel droplet-embedded drug sensitivity test.2019

    • Author(s)
      Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Nagayasu K, Sakuyama N, Sato T, Kishine K, Abe Y, Nagaoka I
    • Journal Title

      Oncol Lett

      Volume: 17 Pages: 1842-1850

    • DOI

      10.3892/ol.2018.9805

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MrgX2-mediated internalization of LL-37 and degranulation of human LAD2 mast cells.2018

    • Author(s)
      Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I.
    • Journal Title

      Molecular Medicine Reports

      Volume: 18 Pages: 4951-4959

    • DOI

      10.3892/mmr.2018.9532

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protection of the endothelial glycocalyx by antithrombin in an endotoxin-induced rat model of sepsis.2018

    • Author(s)
      Iba T, Levy JH, Hirota T, Hiki M, Sato K, Murakami T, Nagaoka I.
    • Journal Title

      Thrombosis Research

      Volume: 171 Pages: 1-6

    • DOI

      10.1016/j.thromres.2018.09.042

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the effect of the administration of a glucosamine-containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double-blind placebo-controlled study.2018

    • Author(s)
      Tsuruta A, Horiike T, Yoshimura M, Nagaoka I
    • Journal Title

      Mol Med Rep

      Volume: 18 Pages: 3941-3948

    • DOI

      10.3892/mmr.2018.9396

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of the kinetics and mechanism of low endotoxin recovery in a matrix for biopharmaceutical drug products.2018

    • Author(s)
      Reich J, Tamura H, Nagaoka I.
    • Journal Title

      Biologicals

      Volume: 53 Pages: 1-9

    • DOI

      10.1016/j.biologicals.2018.04.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] JAK2/STAT3 pathway as a therapeutic target in ovarian cancers.2018

    • Author(s)
      Yoshikawa T, Miyamoto M, Aoyama T, Soyama H, Goto T, Hirata J, Suzuki A, Nagaoka I, Tsuda H, Furuya K, Takano M
    • Journal Title

      Oncol Lett

      Volume: 15 Pages: 5772-5780

    • DOI

      10.3892/ol.2018.8028

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effect of a newly developed fucose-deficient recombinant antithrombin against histone-induced endothelial damage.2018

    • Author(s)
      Iba T, Hirota T, Sato K, Nagaoka I
    • Journal Title

      International Journal of Hematology

      Volume: 107 Issue: 5 Pages: 528-534

    • DOI

      10.1007/s12185-018-2402-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model.2017

    • Author(s)
      Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I, Sakamoto K
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 13 Issue: 6 Pages: 2969-2974

    • DOI

      10.3892/etm.2017.4308

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide.2017

    • Author(s)
      Hu Z, Murakami T, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoka I.
    • Journal Title

      Int J Mol Med.

      Volume: in press Issue: 3 Pages: 549-558

    • DOI

      10.3892/ijmm.2017.2870

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model.2017

    • Author(s)
      Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I
    • Journal Title

      Molecular Medicine Reports

      Volume: 16 Issue: 4 Pages: 5618-5626

    • DOI

      10.3892/mmr.2017.7267

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The comparison of the protective effects of α- and β-antithrombin against vascular endothelial cell damage induced by histone in vitro.2017

    • Author(s)
      Iba T, Sasaki T, Ohshima K, Sato K, Nagaoka I, Thachil J
    • Journal Title

      TH Open

      Volume: 1 Issue: 01 Pages: e3-e10

    • DOI

      10.1055/s-0037-1603926

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Therapeutic potential of cathelicidin peptide LL-37, an antimicrobial agent, in a murine sepsis model2021

    • Author(s)
      Nagaoka I
    • Organizer
      2021 11th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体防御ペプチドLL-37は、抗菌活性を有する細胞外小胞の放出を介してマウス敗血症の病態改善をする2021

    • Author(s)
      熊谷由美, 角田宗一郎, 桒原京子, 長岡 功
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] スポーツと未病:アスリートの軟骨代謝に及ぼす機能性表示食品グルコサミンの効果2021

    • Author(s)
      長岡 功, 染谷明正, 五十嵐庸, 吉村雅文
    • Organizer
      第28回日本未病システム学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] アスリートの軟骨代謝とグルコサミンの軟骨保護作用 -抗炎症作用とオートファジー誘導作用-2021

    • Author(s)
      長岡 功
    • Organizer
      第26回ifia JAPAN 2021(国際食品素材/添加物展・会議)・第19回HFE JAPAN 2021(ヘルスフードエキスポ)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] コラーゲンペプチドとグルコサミンの関節機能に及ぼす効果2021

    • Author(s)
      長岡 功
    • Organizer
      機能性食品用ペプチド研究会(60回)&美容・アンチエイジング食品研究会(35回)第7回合同研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] LL-37 ameliorates mouse sepsis by inducing the secretion of antibacterial extracellular vesicles2021

    • Author(s)
      Kumagai Y, Kakuta S, Kuwahara K, Susaki E, Nagaoka I
    • Organizer
      10th Annual Meeting ISEV (International Society of Extracellular Vesicles) 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト抗菌ペプチドLL-3による血管内皮細胞のオートファジー誘導と細胞死のメカニズム2021

    • Author(s)
      鈴木 香, 長岡 功
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アセチルグルコサミンによる炎症性サイトカイン産生の抑制 -グルコサミンとの比較-2021

    • Author(s)
      染谷明正, 洲﨑悦生, 長岡 功
    • Organizer
      第28回日本未病システム学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Recent findings of chondroprotective and antiinflammatory actions of glucosamine, a chitosan monomer2020

    • Author(s)
      Nagaoka I
    • Organizer
      The 30th Annual Meeting and International Symposium, The Korean Society of Chitin and Chitosan
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] キチン・キトサンからグルコサミンまで2020

    • Author(s)
      長岡 功
    • Organizer
      食のミライ技術フェア2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] グルコサミンの抗炎症作用2020

    • Author(s)
      長岡 功
    • Organizer
      食品開発展2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 生体防御ペプチドLL-37 の敗血症モデルに対する保護効果2020

    • Author(s)
      長岡 功, 熊谷由美, 細田浩司, 村上泰介, 鈴木 香
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Invited
  • [Presentation] Antimicrobial peptide LL-37 induces antibacterial ectosomes from neutrophils2020

    • Author(s)
      熊谷由美, 村上泰介, 桑原京子, 長岡 功
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Invited
  • [Presentation] ヒト抗菌ペプチドLL-37 が血管内皮細胞のオートファジーおよび細胞死に及ぼす影響2020

    • Author(s)
      鈴木 香, 大熊真理, 長岡 功
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 生体防御ペプチドLL-37による抗菌活性を有する細胞外小胞の放出を介したマウス敗血症の病態改善2020

    • Author(s)
      熊谷由美, 射場敏明, 長岡 功
    • Organizer
      第7回日本細胞外小胞学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Antimicrobial peptide LL-37 induces neutrophil-derived extracellular vesicles with antibacterial potential and protects murine sepsis2020

    • Author(s)
      Kumagai Y, Murakami T, Kuwahara K, Nagaoka I
    • Organizer
      ISEV (International Society of Extracellular Vesicles) 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒト抗菌ペプチドLL-37 が血管内皮細胞のオートファジーおよび細胞死に及ぼす影響2020

    • Author(s)
      鈴木 香, 大熊真理, 長岡 功
    • Organizer
      93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] グルコサミンと健康 -グルコサミンの軟骨保護作用と抗炎症作用2019

    • Author(s)
      長岡 功
    • Organizer
      第14回ファンクショナルフード学会・研修会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Recent aspects of the chondroprotective and antiinflammatory actions of glucosamine, a chitosan monomer.2019

    • Author(s)
      Nagaoka I
    • Organizer
      The 29th Annual Meeting & International Symposium, The Korean Society for Chitin and Chitosan
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] アスリートの軟骨代謝に及ぼす機能性食品の効果2019

    • Author(s)
      長岡 功
    • Organizer
      第24回ifia JAPAN 2019(国際食品素材/添加物展・会議)・第17回HFE JAPAN 2019(ヘルスフードエキスポ)
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 機能性食品の軟骨代謝に及ぼす影響2019

    • Author(s)
      長岡 功, 鶴田曉史, 堀池 巧, 吉村雅文
    • Organizer
      日本農芸化学会2019年度(平成31年度)大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 老化血管内皮細胞におけるLPS応答の増強効果2019

    • Author(s)
      鈴木 香, 大熊真理, 長岡 功
    • Organizer
      第25回日本エンドトキシン・自然免疫研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 抗菌ペプチドLL-37による好中球細胞外(エクトソーム)の放出を介したマウス敗血症の病態改善2019

    • Author(s)
      熊谷由美, 村上泰介, 桒原 京子, 長岡 功
    • Organizer
      第6回日本細胞外小胞学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヒト抗菌ペプチドLL-37が血管内皮細胞のオートファジーおよび細胞死に及ぼす影響2019

    • Author(s)
      鈴木 香, 大熊真理, 長岡 功
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 抗菌ペプチドLL-37は好中球からの細胞外小胞の放出を介してマウス敗血症を改善する2019

    • Author(s)
      熊谷由美, 村上泰介, 長岡 功
    • Organizer
      第66回トキシンシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] Antimicrobial peptide LL-37 ameliorates mouse sepsis through microparticle release from neutrophils2019

    • Author(s)
      熊谷由美, 村上泰介, 桑原京子, 長岡 功
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 老化血管内皮細胞におけるLPS炎症応答の増幅効果2019

    • Author(s)
      鈴木 香,長岡 功
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] MrgX2 を介した抗菌ペプチドLL-37 のマスト細胞内への移行と脱顆粒2019

    • Author(s)
      村上泰介, 鈴木 香, 長岡 功
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 宿主細胞の細胞死に注目した、抗菌ペプチドLL-37の敗血症マウスモデルに対する効果.2018

    • Author(s)
      長岡 功
    • Organizer
      第33回日本Shock学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Chondroprotective action of glucosamine, a chitosan monomer, on the joint health of athletes.2018

    • Author(s)
      Nagaoka I
    • Organizer
      14th ICCC/12th APCCS/32nd JSCCC
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗菌ペプチドLL-37による好中球細胞外小胞(エクトソーム)の産生を介したマウス敗血症の病態改善.2018

    • Author(s)
      熊谷由美, 村上泰介, 桒原京子, Reich Johannes, 田村弘志, 長岡 功
    • Organizer
      第24回日本エンドトキシン・自然免疫研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 好中球細胞外小胞の産生を介したLL-37によるマウス敗血症の病態改善.2018

    • Author(s)
      熊谷由美, 村上泰介, 桒原京子, 射場敏明, 長岡 功
    • Organizer
      第101回日本細菌学会関東支部総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Human cathelicidin peptide LL-37 ameliorates sepsis in a mouse model through induction of microparticles with antibacterial potential from neutrophils.2018

    • Author(s)
      Kumagai Y, Murakami T, Reich J, Tamura H, Nagaoka I
    • Organizer
      Joint Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] MrgX2-mediated internalization of LL-37 and degranulation of human LAD2 mast cells.2018

    • Author(s)
      Murakami T, Suzuki K, Niyonsaba F, Reich J, Tamura H, Nagaoka I
    • Organizer
      oint Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒト抗菌ペプチドLL-37による血管内皮細胞のオートファジーと細胞死に対する作用.2018

    • Author(s)
      鈴木 香, 大熊真理, 長岡 功
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Mas-related gene X2を介した、マスト細胞への抗菌ペプチドLL-37細胞内移行と脱顆粒応答.2018

    • Author(s)
      村上泰介, 森林叔子, 鈴木 香, 長岡 功
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Antimicrobial peptide LL-37 induces microparticle release from neutrophils in a mouse sepsis model.2018

    • Author(s)
      熊谷由美,Li Yan,村上泰介,田村弘志,長岡 功
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Analysis of the components of neutrophil-derived microparticles with antibacterial activity.2018

    • Author(s)
      Li Yan,熊谷由美,鈴木 香,長岡 功
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒト抗菌ペプチド LL-37 による血管内皮細胞のオートファジー誘導.2018

    • Author(s)
      鈴木 香,大熊真理,長岡 功
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 抗菌ペプチドLL-37はNET形成を誘導して敗血症マウスモデルの生存率を改善する.2017

    • Author(s)
      細田浩司, 中村果歩, 胡 忠双, 田村弘志, 長岡 功
    • Organizer
      第64回トキシンシンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] NETs形成に注目した、抗菌ペプチドLL-37の敗血症マウスモデルに対する効果の検討.2017

    • Author(s)
      長岡 功, 細田浩司, 中村果歩, 胡 忠双, 村上泰介, 鈴木 香, 田村弘志
    • Organizer
      第23回日本エンドトキシン・自然免疫研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Antimicrobial cathelicidin peptide LL-37 protects septic mice by modulating macrophage pyroptosis and neutrophil NETosis.2017

    • Author(s)
      Nagaoka Isao, Hosoda Hiroshi, Hu Zhongshuang, Nakamura Kaho, Murakami Taisuke, Tamura Hiroshi, Johannes
    • Organizer
      Society for Leukocyte Biology 50th Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 理学療法NAVI リスクに備えて臨床に活かす 理学療法にすぐに役立つ薬の知識2021

    • Author(s)
      長岡 功
    • Total Pages
      352
    • Publisher
      医学書院
    • ISBN
      9784260043410
    • Related Report
      2021 Annual Research Report
  • [Book] エンドトキシン・自然免疫研究23 -エンドトキシン研究の基礎から臨床へ、新しい時代へのアプローチ2020

    • Author(s)
      鈴木 香, 長岡 功
    • Total Pages
      86
    • Publisher
      医学図書出版株式会社
    • Related Report
      2020 Research-status Report
  • [Book] エンドトキシン・自然免疫研究23 -エンドトキシン研究の基礎から臨床へ、新しい時代へのアプローチ2020

    • Author(s)
      田村弘志, Johannes Reich, 長岡 功
    • Total Pages
      86
    • Publisher
      医学図書出版株式会社
    • Related Report
      2020 Research-status Report
  • [Book] Functional Food Research 16 機能性食品とスクラム形成2020

    • Author(s)
      長岡 功
    • Total Pages
      137
    • Publisher
      インフォノーツパブリッシング
    • Related Report
      2020 Research-status Report
  • [Book] エンドトキシン・自然免疫研究22 -エンドトキシン・自然免疫研究の新たな可能性を求めて2019

    • Author(s)
      Kracklauer M, Tamura H, Nagaoka I, Reich J
    • Total Pages
      82
    • Publisher
      医学図書出版株式会社
    • Related Report
      2019 Research-status Report
  • [Book] エンドトキシン・自然免疫研究22 -エンドトキシン・自然免疫研究の新たな可能性を求めて2019

    • Author(s)
      熊谷由美, 村上泰介, 桒原京子, Reich Johannes, 田村弘志, 長岡 功
    • Total Pages
      82
    • Publisher
      医学図書出版株式会社
    • Related Report
      2019 Research-status Report
  • [Book] 分子栄養学 -科学的根拠に基づく食理学2019

    • Author(s)
      長岡 功
    • Total Pages
      241
    • Publisher
      東京化学同人
    • ISBN
      9784807916733
    • Related Report
      2019 Research-status Report
  • [Book] エンドトキシン・自然免疫研究21- エンドトキシン・自然免疫研究のフロンティアをめざして2018

    • Author(s)
      長岡 功, 細田浩司, 中村果歩, 胡 忠双, 村上泰介, 鈴木 香, 田村弘志
    • Total Pages
      69
    • Publisher
      医学図書出版株式会社
    • Related Report
      2018 Research-status Report
  • [Book] 血流改善成分の開発と応用2018

    • Author(s)
      長岡功
    • Total Pages
      231
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313412
    • Related Report
      2018 Research-status Report
  • [Book] 抗菌ペプチドの機能解明と技術利用2017

    • Author(s)
      長岡 功
    • Total Pages
      239
    • Publisher
      シーエムシー出版
    • ISBN
      9784781312453
    • Related Report
      2017 Research-status Report
  • [Remarks] 順天堂大学大学院医学研究科生化学・生体防御学ホームページ

    • URL

      https://www.juntendo.ac.jp/graduate/laboratory/labo/seikagaku_seitaibogyo/html/book1_j.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] 順天堂大学大学院医学研究科生化学・生体防御学ホームページ

    • URL

      https://www.juntendo.ac.jp/graduate/laboratory/labo/seikagaku_seitaibogyo/html/index_j.html

    • Related Report
      2020 Research-status Report 2019 Research-status Report 2018 Research-status Report
  • [Remarks] 順天堂大学大学院医学研究科生化学・生体防御学ホームページ

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/seikagaku_seitaibogyo/html/index_j.html

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi