• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanism of HSV cell-to-cell-spread

Research Project

Project/Area Number 17K08851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Virology
Research InstitutionKobe University (2019-2020)
The University of Tokyo (2017-2018)

Principal Investigator

Arii Jun  神戸大学, 医学研究科, 特命准教授 (30704928)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords単純ヘルペスウイルス / 糖タンパク質 / 細胞間伝播 / MEK/ERKシグナル / HSV / ヘルペスウイルス / 細胞内シグナル / ウイルス / ウイルス粒子形成 / 膜タンパク質 / レセプター
Outline of Final Research Achievements

Herpesviruses are ubiquitous pathogens of various animals, including humans. These viruses primarily pass through cell junctions to spread to uninfected cells. This method of cell-to-cell spread is an important pathogenic characteristic of these viruses. Here, we show that the host cell protein prohibitin-1 contributes to HSV-1 cell-to-cell spread via a downstream intracellular signaling cascade, the MAPK/ERK pathway. We also demonstrate that the role of the prohibitin-1-mediated MAPK/ERK pathway in viral cell-to-cell spread is conserved in representative members of every herpesvirus subfamily. This study has revealed a common molecular mechanism of the cell-to-cell spread of herpesviruses.

Academic Significance and Societal Importance of the Research Achievements

ヒトを宿主とするヘルペスウイルスは9種存在するが、その中には抗ウイルス剤がほぼ効果がないものも存在する。本研究が同定したPHB1およびMEK/ERKシグナルは、HSVだけでなく、ヘルペスウイルス科に属する三つの亜科すべてに共通して細胞間伝播を促進していた。すなわち本研究により、MEK/ERKシグナルに対する阻害剤は、すべてのヘルペスウイルス感染症に効果のある新規抗ヘルペスウイルス剤のターゲットとなりうる可能性が、提示できたと考えられる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (62 results)

All 2020 2019 2018 2017 Other

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 13 results,  Acknowledgement Compliant: 1 results) Presentation (37 results) (of which Int'l Joint Research: 13 results,  Invited: 4 results) Book (2 results) Remarks (8 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Prohibitin-1 Contributes to Cell-to-Cell Transmission of Herpes Simplex Virus 1 via the MAPK/ERK Signaling Pathway2020

    • Author(s)
      Watanabe Mizuki、Arii Jun、Takeshima Kosuke、Fukui Ayano、Shimojima Masayuki、Kozuka-Hata Hiroko、Oyama Masaaki、Minamitani Takeharu、Yasui Teruhito、Kubota Yuji、Takekawa Mutsuhiro、Kosugi Isao、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 3

    • DOI

      10.1128/jvi.01413-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Phosphatidylethanolamine Biosynthesis in Herpes Simplex Virus 1-Infected Cells in Progeny Virus Morphogenesis in the Cytoplasm and in Viral Pathogenicity in Vivo2020

    • Author(s)
      Arii Jun、Fukui Ayano、Shimanaka Yuta、Kono Nozomu、Arai Hiroyuki、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 94 Issue: 24

    • DOI

      10.1128/jvi.01572-20

    • URL

      https://pure.teikyo.jp/en/publications/96330edf-3a7e-4970-b1dc-574ba509a5bc

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ESCRT-III controls nuclear envelope deformation induced by progerin2020

    • Author(s)
      Arii Jun、Maeda Fumio、Maruzuru Yuhei、Koyanagi Naoto、Kato Akihisa、Mori Yasuko、Kawaguchi Yasushi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 18877-18877

    • DOI

      10.1038/s41598-020-75852-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication.2019

    • Author(s)
      Takeshima K, Arii J, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 93 Issue: 21

    • DOI

      10.1128/jvi.01290-19

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of the Interhexamer Contact Site for Hexagonal Lattice Formation of the Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication.2019

    • Author(s)
      Arii J, Takeshima K, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 93 Issue: 14

    • DOI

      10.1128/jvi.00498-19

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity.2018

    • Author(s)
      Arii J, Watanabe M, Maeda F, Tokai-Nishizumi N, Chihara T, Miura M, Maruzuru Y, Koyanagi N, Kato A, Kawaguchi Y.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 3379-3379

    • DOI

      10.1038/s41467-018-05889-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.2018

    • Author(s)
      Sato R, Kato A, Chimura T, Saitoh SI, Shibata T, Murakami Y, Fukui R, Liu K, Zhang Y, Arii J, Sun-Wada GH, Wada Y, Ikenoue T, Barber GN, Manabe T, Kawaguchi Y, Miyake K.
    • Journal Title

      Nat Immunol.

      Volume: 19 Issue: 10 Pages: 1071-1082

    • DOI

      10.1038/s41590-018-0203-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity.2018

    • Author(s)
      Kato A, Oda S, Watanabe M, Oyama M, Kozuka-Hata H, Koyanagi N, Maruzuru Y, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 92 Issue: 18

    • DOI

      10.1128/jvi.01035-18

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis.2018

    • Author(s)
      Koyanagi N, Kato A, Takeshima K, Maruzuru Y, Kozuka-Hata H, Oyama M, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 92 Issue: 17

    • DOI

      10.1128/jvi.00807-18

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of HSV Glycoproteins in Mediating Cell Entry.2018

    • Author(s)
      Arii J, Kawaguchi Y.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 1045 Pages: 3-21

    • DOI

      10.1007/978-981-10-7230-7_1

    • ISBN
      9789811072291, 9789811072307
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018

    • Author(s)
      Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
    • Journal Title

      Cell Host Microbe.

      Volume: 23 Issue: 2 Pages: 254-265

    • DOI

      10.1016/j.chom.2017.12.014

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells.2017

    • Author(s)
      F. Maeda, J. Arii, Y. Hirohata, Y. Maruzuru, N. Koyanagi, A. Kato and Y. Kawaguchi.
    • Journal Title

      J. Virol.

      Volume: 印刷中 Issue: 12

    • DOI

      10.1128/jvi.00271-17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Herpes Simplex Virus 1 Small Capsomere-Interacting Protein VP26 Regulates Nucleocapsid Maturation.2017

    • Author(s)
      Kobayashi R, Kato A, Sagara H, Watanabe M, Maruzuru Y, Koyanagi N, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 91 Issue: 18

    • DOI

      10.1128/jvi.01068-17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.2017

    • Author(s)
      Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.
    • Journal Title

      J Clin Invest.

      Volume: 127 Issue: 10 Pages: 3784-3795

    • DOI

      10.1172/jci92931

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 単純ヘルペスウイルスによる核膜通過の分子機構2019

    • Author(s)
      有井 潤
    • Organizer
      ウイルス研究の潮流シリーズセミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 単純ヘルペスウイルスによる核膜の再構築2019

    • Author(s)
      有井潤、川口寧
    • Organizer
      第92回 日本生化学会 シンポジウム・病原体と宿主が交差するオルガネラ・ゾーン
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] HSV-1 Nuclear Egress Complex カプシド結合部位のウイルス増殖における役割2019

    • Author(s)
      竹島 功高、有井 潤、丸鶴 雄平、小柳 直人、加藤 哲久、川口 寧
    • Organizer
      第67回 日本ウイルス学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Roles of the Inter-Hexamer Contact Site for Hexagonal Lattice Formation of Herpes Simplex Virus 1 Nuclear Egress Complex in Viral Primary Envelopment and Replication2019

    • Author(s)
      Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第18回 あわじ感染と免疫国際フォーラム
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of the Capsid Binding Site in the Herpes Simplex Virus 1 Nuclear Egress Complex and Its Role in Viral Primary Envelopment and Replication2019

    • Author(s)
      Kosuke Takeshima, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第18回 あわじ感染と免疫国際フォーラム
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] HSV-1 UL-31/UL-34六量体間結合は、核膜間のウイルス粒子形成とウイルス増殖に貢献する2018

    • Author(s)
      有井潤, 竹島功高, 丸鶴雄平, 小栁直人, 加藤哲久, 川口寧
    • Organizer
      第32回ヘルペスウイルス研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Primary EnvelopmentにおけるHSV-1 UL31 α-helix9の役割2018

    • Author(s)
      竹島功高, 有井潤, 丸鶴雄平, 小栁直人, 加藤哲久, 川口寧
    • Organizer
      第32回ヘルペスウイルス研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Molecular mechanisms of entry and egress of herpes simplex virus 12018

    • Author(s)
      Jun Arii
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] A single amino acid substitution in HSV-1 UL31 at an inter-hexamer contact site abrogates primary envelopment and viral growth2018

    • Author(s)
      Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Residues in α-helix 9 of HSV-1 UL31 is critical for interaction with UL25 and incorporation of capsid into vesicles in the perinuclear space2018

    • Author(s)
      Kosuke Takeshima, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第66回日本ウイルス学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity2018

    • Author(s)
      有井潤, 渡邉瑞季, 前田史雄, 丸鶴雄平, 小栁直人, 加藤哲久, 川口寧
    • Organizer
      第18回東京大学生命科学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] A single amino acid substitution in herpes simplex virus 1 UL31 at an inter-hexamer contact site abrogates primary envelopment and viral growth2018

    • Author(s)
      Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      43rd Annual International Herpesvirus Workshop
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of amino acid residues in the α-helix 9 of HSV-1 UL31 in its interaction with capsid proteins and nuclear egress2018

    • Author(s)
      Kosuke Takeshima, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      43rd Annual International Herpesvirus Workshop
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A single amino acid substitution in herpes simplex virus 1 UL31 at an inter-hexamer contact site abrogates primary envelopment and viral growth2018

    • Author(s)
      Jun Arii, Kosuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      The 17th Awaji International Forum on Infection and Immunity
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of amino acid residues in the α-helix 9 of HSV-1 UL31 in its interaction with capsid proteins and nuclear egress2018

    • Author(s)
      Kosuke Takeshima, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      The 17th Awaji International Forum on Infection and Immunity
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 単純ヘルペスウイルス(HSV)の細胞間伝播を促進する宿主細胞膜タンパク質の同定2017

    • Author(s)
      渡邉瑞季, 有井潤, 下島昌幸, 加藤哲久, 川口寧
    • Organizer
      第14回ウイルス学キャンプ in 湯河原
    • Related Report
      2017 Research-status Report
  • [Presentation] 単純ヘルペスウイルスと宿主細胞膜との相互作用2017

    • Author(s)
      有井 潤
    • Organizer
      第14回ウイルス学キャンプ in 湯河原
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] HSV-1 UL51 リン酸化制御機構と細胞種依存的な新規機能の解明2017

    • Author(s)
      尾田真也, 加藤哲久, 丸鶴雄平, 小栁直人, 有井潤, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] HSV-2のウイルス増殖および病原性はUL13プロテインキナーゼのリン酸化によって制御される2017

    • Author(s)
      小栁直人, 加藤哲久, 丸鶴雄平, 有井潤, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] ESCRT-IIIは小胞媒介性核外輸送における膜切断を仲介し、核内膜の恒常性維持に寄与する2017

    • Author(s)
      有井潤, 渡邉瑞季, 前田史雄, 加藤哲久, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inhibition of AIM2 inflammasome activation by an HSV-1 virion component enables efficient viral replication in vivo2017

    • Author(s)
      Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Jun Arii, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 単純ヘルペスウイルス1型UL34は小胞体の形態制御を行い、ヌクレオカプシドの核出芽輸送制御因子の核膜への集積に関与する2017

    • Author(s)
      前田史雄, 廣畑吉崇, 有井潤, 加藤哲久, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 単純ヘルペスウイルス(HSV)の細胞間感染を促進する宿主タンパク質の同定2017

    • Author(s)
      渡邉瑞季, 有井潤, 下島昌幸, 加藤哲久, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヘルペスウイルスカプシドの核外輸送は宿主機構のハイジャックによって達成される2017

    • Author(s)
      有井潤, 渡邉瑞季, 川口寧
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 単純ヘルペスウイルスgEと相互作用して細胞間感染を促進する宿主因子の同定2017

    • Author(s)
      渡邉瑞季, 有井潤, 下島昌幸, 川口寧
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ESCRT-III mediates vesicle-mediated nuclear export to regulate nuclear egress of HSV-1 capsids and integrity of the inner nuclear membrane2017

    • Author(s)
      Jun Arii, Mizuki Watanabe, Fumio Maeda, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Cell type-specific regulation of the nuclear egress of herpes simplex virus type1 by phosphorylation of UL51 Ser-1842017

    • Author(s)
      Shinya Oda, Akihisa Kato, Yuhei Maruzuru, Naoto Koyanagi, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Evasion of AIM2-Dependent Inflamasome Activation by Herpes Simplex Virus 1 Virion Protein Enables Efficient Viral Replication In Vivo2017

    • Author(s)
      Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Zhuoming Liu, Tomoko Ando, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] A host cell membrane protein interacts with HSV-1 gE and promotes viral cell-to-cell spread2017

    • Author(s)
      Mizuki Watanabe, Jun Arii, Masayuki Shimojima, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Function of the herpes simplex virus 2 protein kinase UL13 in vitro and in vivo is regulated by phosphorylation2017

    • Author(s)
      Naoto Koyanagi, Akihisa Kato, Yuhei Maruzuru, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Molecular mechanism of HSV-1 nuclear egress2017

    • Author(s)
      Jun Arii
    • Organizer
      CAS-IMSUT Workshop on Infectious Diseases
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inhibition of AIM2 inflammasome activation by an HSV-1 virion component enables efficient viral replication in vivo2017

    • Author(s)
      Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Jun Arii, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of a host cell membrane protein that interacts with HSV-1 gE and promotes viral cell-to-cell spread2017

    • Author(s)
      Mizuki Watanabe, Jun Arii, Masayuki Shimojima, Naoto Koyanagi, Yuhei Maruzuru, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Herpes simplex virus type 1 UL51 Protein Regulates Virion Morphogenesis in the Nucleus in a Cell type and Phosphorylation-Dependent Manner2017

    • Author(s)
      Shinya Oda, Akihisa Kato, Naoto Koyanagi, Yuhei Maruzuru, Jun Arii and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ESCRT-III mediates vesicle-mediated nuclear export and regulates the integrity of the inner nuclear membrane2017

    • Author(s)
      Jun Arii, Mizuki Watanabe, Fumio Maeda, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Regulation of herpes simplex virus-2 UL13 protein kinase by phosphorylation is important for viral replication, pathogenic manifestations, and virulence in vivo2017

    • Author(s)
      Naoto Koyanagi, Akihisa Kato, Yuhei Maruzuru, Jun Arii and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Herpes simplex 1 UL34 Protein Regurates the Global Architecture of the Endoplasmic Reticulum in Infected Cells2017

    • Author(s)
      Fumio Maeda, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 日本医師会雑誌 149巻第7号 ヘルペスウイルス感染症2020 HHV-62020

    • Author(s)
      森 康子、有井 潤
    • Total Pages
      1
    • Publisher
      日本医師会
    • Related Report
      2020 Annual Research Report
  • [Book] 月刊細胞 2017年 12月号2017

    • Author(s)
      有井潤、川口寧
    • Total Pages
      3
    • Publisher
      ニューサイエンス社
    • Related Report
      2017 Research-status Report
  • [Remarks] 神戸大学大学院医学研究科附属感染症研究センターのホームページ

    • URL

      https://www.med.kobe-u.ac.jp/virol/index.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 東京大学 医科学研究所 ウイルス病態制御分野

    • URL

      https://www.ims.u-tokyo.ac.jp/Kawaguchi-lab/KawaguchiLabTop.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 神戸大学 大学院医学研究科 臨床ウイルス学分野

    • URL

      https://www.med.kobe-u.ac.jp/virol/index.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 研究室のホームページ

    • URL

      http://www.ims.u-tokyo.ac.jp/Kawaguchi-lab/KawaguchiLabTop.html

    • Related Report
      2018 Research-status Report
  • [Remarks] 研究成果発表のプレスリリース

    • URL

      http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_107.php

    • Related Report
      2018 Research-status Report
  • [Remarks] 研究室のホームページ

    • URL

      http://www.ims.u-tokyo.ac.jp/kawaguchi-lab/KawaguchiLabTop.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 研究成果のプレスリリース

    • URL

      http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_98.php

    • Related Report
      2017 Research-status Report
  • [Remarks] 研究成果のプレスリリース

    • URL

      http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_90.php

    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 新規ウイルス増殖阻害剤2020

    • Inventor(s)
      川口 寧、有井 潤
    • Industrial Property Rights Holder
      国立大学法人 東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-158247
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi