Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
Siglecs are a family of cell-surface immune receptors that bind to sialic acid at terminal glycan residues. We found that Siglec5 and Siglec14 recognize pathogenic fungi, Trichophyton spp. Trichophyton spp modulated host immune responses via Siglec5 and 14. Biochemical approaches revealed that the Siglec ligands are fungal alkanes and triacylglycerols. Furthermore, Siglec5 weakly recognized several endogenous lipids. Among them, cardiolipin and 5-PAHSA exhibited potent ligand activity on Siglec5. Further, the hydrophobic stretch in the Siglec5 N terminus region was found to be required for efficient recognition of these lipids.
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