Immune evasion strategy of pathogenic fungi via inhibitory receptors
Project/Area Number |
17K08888
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Immunology
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Research Institution | Saga University |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | レクチン受容体 / Siglec / 脂質リガンド / 免疫抑制型受容体 / 免疫回避機構 |
Outline of Final Research Achievements |
Siglecs are a family of cell-surface immune receptors that bind to sialic acid at terminal glycan residues. We found that Siglec5 and Siglec14 recognize pathogenic fungi, Trichophyton spp. Trichophyton spp modulated host immune responses via Siglec5 and 14. Biochemical approaches revealed that the Siglec ligands are fungal alkanes and triacylglycerols. Furthermore, Siglec5 weakly recognized several endogenous lipids. Among them, cardiolipin and 5-PAHSA exhibited potent ligand activity on Siglec5. Further, the hydrophobic stretch in the Siglec5 N terminus region was found to be required for efficient recognition of these lipids.
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Academic Significance and Societal Importance of the Research Achievements |
これまでSiglecはシアル酸を認識する受容体として様々な生命現象に関与することが明らかにされてきた。が、本研究によりSiglecが脂質リガンドを認識することが明らかになったことで、Siglecの生理的・病理的機能の理解が新たな方向へと進展する可能性が期待される。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice.2019
Author(s)
Asako Ishikawa, Yasunobu Miyake, Kimiko Kobayashi, Yuzo Murata, Sayaka Iizasa, Ei’ichi Iizasa, Sho Yamasaki, Naomi Hirakawa, Hiromitsu Hara, Hiroki Yoshida, Toshiharu Yasaka
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Journal Title
Scientific Reports
Volume: 9
Issue: 1
Pages: 872-872
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells.2018
Author(s)
Tong, H., Miyake, Y., Mi-Ichi, F., Iwakura, Y., Hara, H. and Yoshida, H.
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Journal Title
PLoS One
Volume: 13
Issue: 3
Pages: 0195119-0195119
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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