| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
mTORC1 is a signal transduction molecule that senses nutritional and energy states around cells, and is involved in immune cell differentiation and cytokine expression. Here we show that the amino acid-mTORC1 signal is involved in the regulation of GM-CSF expression in mouse epidermal keratinocytes. In addition, we have revealed that the amino acid treatment may have a therapeutic effect on dermatitis, based on an analysis using an irritant contact dermatitis model in which GM-CSF is known to be an exacerbation factor for inflammation as well as psoriasis.
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