炭素線治療における解剖学的変化に応じたリアルタイム照射ビーム生成法の研究

• Project/Area Number: 17K09056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Gunma University
• Principal Investigator: 久保田 佳樹 群馬大学, 重粒子線医学推進機構, 助教 (40583076)
• Co-Investigator(Kenkyū-buntansha): 大野 達也 群馬大学, 大学院医学系研究科, 教授 (10344061) ; 山口 充孝 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員(定常) (10375404) ; 酒井 真理 群馬大学, 大学院医学系研究科, 助教 (70727338)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Discontinued (Fiscal Year 2020)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 炭素線治療 / adaptive / 可変ボーラス / ビームイメージング / 膵臓がん / 飛程変化 / 炭素線 / passive照射法 / リアルタイム / 制動放射 / ボーラス / 照射ビーム生成 / 解剖学的変化

Outline of Annual Research Achievements

本研究はpassive照射法での炭素線治療中の患者の解剖学的な変化を検出し、その変化に応じてリアルタイムに照射ビームを変化させることを目的とする。この方法を実現するためには、体内（水中）に炭素線が通過した際に発生する制動放射を精度よく検出する技術と、その変化量に応じてpassive照射法でのビームを変化させるためのadaptive可変ボーラスを製作することが必要となる。
2020年度はadaptive可変ボーラスの設計・製作を行った。Adaptive可変ボーラスは大きさの異なる計12枚のアクリル板を3枚積み重ねて、それぞれが上下左右方向から独立に稼働させることによって、自由度の高い凹凸を作り出す機構である。最大で10cm×10cmの照射野に対して、15mmの飛程を変更することが可能である。群馬大学重粒子線医学研究センターの炭素線にて実測した結果、ボーラスの凹の中心部分では1%以下の誤差であるのに対して、周囲5mmの位置では3%を超える誤差があった。これはアクリル板の切削精度やアクリル板可動のずれから発生していると考えられる。本adaptive可変ボーラスは手動で動かす機構であるが、それぞれの板はねじ回転によって動くよう製作しているため、ねじ部分をモーター等で回転させることによって自動可動も可能である。
また、前年度までに開発したビームイメージングが2mmの飛程変化に検知成功結果をまとめた論文がJapaneses Journal of Applied Physcs誌に掲載された。

Research Products

• [Journal Article] Robustness of daily dose for each beam angle and accumulated dose for inter-fractional anatomical changes in passive carbon-ion radiotherapy for pancreatic cancer: Bone matching versus tumor matching (2021)
  • Author(s): Kubota Yoshiki、Okamoto Masahiko、Shiba Shintaro、Okazaki Shohei、Matsui Toshiaki、Li Yang、Itabashi Yusuke、Sakai Makoto、Kubo Nobuteru、Tsuda Kazuhisa、Ohno Tatsuya、Nakano Takashi
  • Journal Title: Radiotherapy and Oncology Volume: 157 Pages: 85-92
  • DOI: 10.1016/j.radonc.2021.01.011
  • Peer Reviewed
• [Journal Article] Determination of Deformable Image Registration Algorithms for Accumulating Dose in Carbon-ion Radiotherapy for Pancreatic Cancer (2021)
  • Author(s): LI YANG、KUBOTA YOSHIKI、OKAMOTO MASAHIKO、SHIBA SHINTARO、OKAZAKI SHOHEI、MATSUI TOSHIAKI、KOMATSU SHUNICHIRO、OHNO TATSUYA
  • Journal Title: Anticancer Research Volume: 41 Issue: 2 Pages: 835-843
  • DOI: 10.21873/anticanres.14836
  • Peer Reviewed / Open Access
• [Journal Article] Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging (2020)
  • Author(s): Sakai Makoto、Parajuli Raj Kumar、Kubota Yoshiki、Kubo Nobuteru、Yamaguchi Mitsutaka、Nagao Yuto、Kawachi Naoki、Kikuchi Mikiko、Arakawa Kazuo、Tashiro Mutsumi
  • Journal Title: Sensors Volume: 20 Issue: 9 Pages: 2453-2453
  • DOI: 10.3390/s20092453
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Inter-fractional Anatomical Changes on Dose Distributions in Passive Carbon-Ion Radiotherapy for Prostate Cancer: Comparison of Vertical and Horizontal Fields (2020)
  • Author(s): Yokoyama A, Kubota Y, Kawamura H, Miyasaka Y, Kubo N, Sato H, Abe S, Tsuda K, Sutou T, Ohno T, Nakano T.
  • Journal Title: Front Oncol Volume: 28;10 Pages: 1264-1264
  • DOI: 10.3389/fonc.2020.01264
  • Peer Reviewed / Open Access
• [Journal Article] Skin Dose Reduction by Layer-Stacking Irradiation in Carbon Ion Radiotherapy for Parotid Tumors. (2020)
  • Author(s): Kubo N, Kubota Y, Oike T, Kawamura H, Sakai M, Imamura A, Komatsu S, Miyasaka Y, Sato H, Musha A, Okano N, Shirai K, Saitoh JI, Chikamatsu K, Ohno T.
  • Journal Title: Front Oncol Volume: 10 Pages: 1396-1396
  • DOI: 10.3389/fonc.2020.01396
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimation of shifts of therapeutic carbon-ion beams owing to cavities in a polyethylene target by measuring prompt X-ray images (2020)
  • Author(s): Yamaguchi Mitsutaka、Yamamoto Seiichi、Kitano Maki、Kubota Yoshiki、Sakai Makoto、Akagi Takashi、Nagao Yuto、Kawachi Naoki
  • Journal Title: Japanese Journal of Applied Physics Volume: 59 Issue: 8 Pages: 087001-087001
  • DOI: 10.35848/1347-4065/aba22a
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma (2020)
  • Author(s): Shiba S, Shibuya K, Okamoto M, Okazaki S, Komatsu S, Kubota Y, Nakano T, Ohno T.
  • Journal Title: Radiat Oncol Volume: 14;15(1) Issue: 1 Pages: 195-195
  • DOI: 10.1186/s13014-020-01634-z
  • Peer Reviewed / Open Access
• [Journal Article] Dose assessment for patients with stage I non-small cell lung cancer receiving passive scattering carbon-ion radiotherapy using daily computed tomographic images: A prospective study (2020)
  • Author(s): Li Yang、Kubota Yoshiki、Kubo Nobuteru、Mizukami Tatsuji、Sakai Makoto、Kawamura Hidemasa、Irie Daisuke、Okano Naoko、Tsuda Kazuhisa、Matsumura Akihiko、Saitoh Jun-ichi、Nakano Takashi、Ohno Tatsuya
  • Journal Title: Radiotherapy and Oncology Volume: 144 Pages: 224-230
  • DOI: 10.1016/j.radonc.2020.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Improved iterative reconstruction method for Compton imaging using median filter (2020)
  • Author(s): Sakai Makoto、Parajuli Raj Kumar、Kubota Yoshiki、Kubo Nobuteru、Kikuchi Mikiko、Arakawa Kazuo、Nakano Takashi
  • Journal Title: PLOS ONE Volume: 15 Issue: 3 Pages: e0229366-e0229366
  • DOI: 10.1371/journal.pone.0229366
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer (2019)
  • Author(s): KUBOTA YOSHIKI、OHNO TATSUYA、KAWASHIMA MOTOHIRO、MURATA KAZUTOSHI、OKONOGI NORIYUKI、NODA SHIN-EI、TSUDA KAZUHISA、SAKAI MAKOTO、TASHIRO MUTSUMI、NAKANO TAKASHI
  • Journal Title: Anticancer Research Volume: 39 Issue: 4 Pages: 1915-1921
  • DOI: 10.21873/anticanres.13300
  • Peer Reviewed / Open Access
• [Journal Article] Comparison between bone matching and marker matching for evaluation of intra- and inter-fractional changes in accumulated dose of carbon ion radiotherapy for hepatocellular carcinoma (2019)
  • Author(s): Kubota Yoshiki、Katoh Hiroyuki、Shibuya Kei、Shiba Shintaro、Abe Satoshi、Sakai Makoto、Yuasa Daichi、Tsuda Kazuhisa、Ohno Tatsuya、Nakano Takashi
  • Journal Title: Radiotherapy and Oncology Volume: 137 Pages: 77-82
  • DOI: 10.1016/j.radonc.2019.04.026
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Intensity- and Contour-Based Deformable Image Registration Accuracy in Pancreatic Cancer Patients (2019)
  • Author(s): Kubota Yoshiki、Okamoto Masahiko、Li Yang、Shiba Shintaro、Okazaki Shohei、Komatsu Shuichiro、Sakai Makoto、Kubo Nobuteru、Ohno Tatsuya、Nakano Takashi
  • Journal Title: Cancers Volume: 11 Issue: 10 Pages: 1447-1447
  • DOI: 10.3390/cancers11101447
  • Peer Reviewed / Open Access
• [Journal Article] Divided-volume matching technique for volume displacement estimation of patient positioning in radiation therapy (2019)
  • Author(s): Tashiro Mutsumi、Kubota Yoshiki、Torikoshi Masami、Ohno Tatsuya、Nakano Takashi
  • Journal Title: Physica Medica Volume: 62 Pages: 1-12
  • DOI: 10.1016/j.ejmp.2019.04.028
  • Peer Reviewed / Open Access
• [Journal Article] Potential Pitfalls of Diaphragm Structural Matching in Carbon-ion Radiotherapy for Pancreatic Cancer (2019)
  • Author(s): ITABASHI YUSUKE、KUBOTA YOSHIKI、OKAMOTO MASAHIKO、TSUDA KAZUHISA、SHIBA SHINTARO、HOSHINO YOSHIHIKO、SUTO TAKAYUKI、OHNO TATSUYA、NAKANO TAKASHI
  • Journal Title: Anticancer Research Volume: 39 Issue: 8 Pages: 4351-4356
  • DOI: 10.21873/anticanres.13603
  • Peer Reviewed / Open Access
• [Journal Article] Deep learning-assisted literature mining for in vitro radiosensitivity data (2019)
  • Author(s): Komatsu Shuichiro、Oike Takahiro、Komatsu Yuka、Kubota Yoshiki、Sakai Makoto、Matsui Toshiaki、Nuryadi Endang、Permata Tiara Bunga Mayang、Sato Hiro、Kawamura Hidemasa、Okamoto Masahiko、Kaminuma Takuya、Murata Kazutoshi、Okano Naoko、Hirota Yuka、Ohno Tatsuya、Saitoh Jun-ichi、Shibata Atsushi、Nakano Takashi
  • Journal Title: Radiotherapy and Oncology Volume: 139 Pages: 87-93
  • DOI: 10.1016/j.radonc.2019.07.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma (2019)
  • Author(s): Kubo Nobuteru、Kubota Yoshiki、Kawamura Hidemasa、Oike Takahiro、Sakai Makoto、Kumazawa Takuya、Miyasaka Yuhei、Okazaki Shohei、Kobayashi Daijiro、Sato Hiro、Mizukami Tatsuji、Musha Atsushi、Shirai Katsuyuki、Saitoh Jun-ichi、Yokoo Satoshi、Chikamatsu Kazuaki、Ohno Tatsuya、Nakano Takashi
  • Journal Title: Radiotherapy and Oncology Volume: 141 Pages: 72-77
  • DOI: 10.1016/j.radonc.2019.07.022
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Carbon-ion Radiotherapy for Isolated Lymph Node Metastasis After Surgery or Radiotherapy for Lung Cancer (2019)
  • Author(s): Shirai Katsuyuki、Kubota Yoshiki、Ohno Tatsuya、Saitoh Jun-ichi、Abe Takanori、Mizukami Tatsuji、Mori Yasumasa、Kawamura Hidemasa、Akahane Keiko、Nakano Takashi
  • Journal Title: Frontiers in Oncology Volume: 9 Pages: 931-931
  • DOI: 10.3389/fonc.2019.00731
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Compton imaging with 99mTc for human imaging (2019)
  • Author(s): Sakai Makoto、Kubota Yoshiki、Parajuli Raj Kumar、Kikuchi Mikiko、Arakawa Kazuo、Nakano Takashi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 12906-12906
  • DOI: 10.1038/s41598-019-49130-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of Dose Distributions When Using Carbon Ion Radiotherapy Versus Intensity-modulated Radiotherapy for Hepatocellular Carcinoma With Macroscopic Vascular Invasion: A Retrospective Analysis (2019)
  • Author(s): SHIBA SHINTARO、SHIBUYA KEI、KAWASHIMA MOTOHIRO、OKANO NAOKO、KAMINUMA TAKUYA、OKAMOTO MASAHIKO、KUBOTA YOSHIKI、NAKANO TAKASHI、OHNO TATSUYA
  • Journal Title: Anticancer Research Volume: 40 Issue: 1 Pages: 459-464
  • DOI: 10.21873/anticanres.13974
  • Peer Reviewed
• [Journal Article] MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment (2019)
  • Author(s): Kawahara Masahiro、Kawamura Hidemasa、Kubota Yoshiki、Katoh Hiroyuki、Kubo Nobuteru、Shimada Hirofumi、Torikai Kota、Torikoshi Masami、Kanai Tatsuaki、Nakano Takashi
  • Journal Title: Journal of Radiation Research Volume: - Issue: 3 Pages: 335-341
  • DOI: 10.1093/jrr/rry111
  • Peer Reviewed / Open Access
• [Journal Article] Value of Three-Dimensional Imaging Systems for Image-Guided Carbon Ion Radiotherapy (2019)
  • Author(s): Li Yang、Kubota Yoshiki、Tashiro Mutsumi、Ohno Tatsuya
  • Journal Title: Cancers Volume: 11 Issue: 3 Pages: 1-13
  • DOI: 10.3390/cancers11030297
  • Peer Reviewed / Open Access
• [Journal Article] Technical Note: Predicting dose distribution with replacing stopping power ratio for inter‐fractional motion and intra‐fractional motion during carbon ion radiotherapy with passive irradiation method for stage I lung cancer (2018)
  • Author(s): Kubota Yoshiki、Sakai Makoto、Tashiro Mutsumi、Saitoh Jun‐ichi、Abe Takanori、Ohno Tatsuya、Nakano Takashi
  • Journal Title: Medical Physics Volume: 45 Issue: 7 Pages: 3435-3441
  • DOI: 10.1002/mp.12966
  • Peer Reviewed
• [Journal Article] Evaluation of the accuracy and clinical practicality of a calculation system for patient positional displacement in carbon ion radiotherapy at five sites (2018)
  • Author(s): Kubota Yoshiki、Hayashi Hayato、Abe Satoshi、Souda Saki、Okada Ryosuke、Ishii Takayoshi、Tashiro Mutsumi、Torikoshi Masami、Kanai Tatsuaki、Ohno Tatsuya、Nakano Takashi
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: 19 Issue: 2 Pages: 144-153
  • DOI: 10.1002/acm2.12261
  • Peer Reviewed / Open Access
• [Journal Article] Potential Pitfalls of a Fiducial Marker-matching Technique in Carbon-ion Radiotherapy for Lung Cancer (2017)
  • Author(s): S Shiba, J Saitoh, D Irie, K Shirai, T Abe, Y Kubota, M Sakai, R Okada, T Ohno, T Nakan
  • Journal Title: Anticancer Research Volume: 37 Issue: 10 Pages: 5673-5680
  • DOI: 10.21873/anticanres.12003
  • Peer Reviewed
• [Journal Article] Robustness of patient positioning for interfractional error in carbon ion radiotherapy for stage I lung cancer: Bone matching versus tumor matching (2017)
  • Author(s): Sakai Makoto、Kubota Yoshiki、Saitoh Jun-ichi、Irie Daisuke、Shirai Katsuyuki、Okada Ryosuke、Torikoshi Masami、Ohno Tatsuya、Nakano Takashi
  • Journal Title: Radiotherapy and Oncology Volume: - Issue: 1 Pages: 95-100
  • DOI: 10.1016/j.radonc.2017.10.003
  • Peer Reviewed
• [Presentation] Feasibility of carbon ion radiotherapy as a new technique in the treatment of retroperitoneal neuroblastoma (2019)
  • Author(s): SC Huijskens, Y Kubota, BV Balgobind, J Visser, IWEM van Dijk, GOR Janssens, T Ohno, A Bel
  • Organizer: PROS conference
  • Int'l Joint Research
• [Presentation] 炭素線治療における治療室CTの重要性、今後の発展について (2019)
  • Author(s): 久保田佳樹、田代睦、大野達也
  • Organizer: 第118回医学物理学会学術大会
  • Invited
• [Presentation] Development of Generating High-Quality Images using Deep Learning for Patient Positioning in Prostate Cancer of Carbon-Ion Radiotherapy (2019)
  • Author(s): 久保田佳樹、早山幸憲、岡本直也、安部聖、想田沙紀、河村英将、田代睦、大野達也、中野隆史
  • Organizer: 第118回医学物理学会学術大会
• [Presentation] Divided-volume matching technique for volume displacement estimation at patient positioning (2019)
  • Author(s): 田代睦、久保田佳樹、大野達也
  • Organizer: 第118回医学物理学会学術大会
• [Presentation] Improvement of reconstruction algorithm for compton camera (2019)
  • Author(s): M Sakai, RK Parajuli, Y Kubota, N Kubo, M Kikuchi, K Arakawa, T Nakano
  • Organizer: IEEE Nuclear Science Symposium (NSS) and Medical Imaging Conference (MIC)
  • Int'l Joint Research
• [Presentation] Operation statistics of Gunma University Heavy Ion Medical Center (2019)
  • Author(s): H Souda, K Yusa, H Shimada, A Matsumura, Y Kubota, M Kawashima, M Sakai, M Tashiro
  • Organizer: ARW2019
  • Int'l Joint Research
• [Presentation] 膵臓がん患者画像における画素値及び輪郭ベースの変形レジストレーションの精度評価 (2019)
  • Author(s): 久保田佳樹、岡本雅彦、Yang Li、柴慎太郎、大野達也、中野隆史
  • Organizer: 日本放射線腫瘍学会第32回学術大会
• [Presentation] 膵臓がんの炭素線治療における日々の変化に対する骨照合と腫瘍照合時の合算線量の評価 (2019)
  • Author(s): 久保田佳樹、岡本雅彦、板橋佑典、柴慎太郎、津田和寿、大野達也、中野隆史
  • Organizer: 日本放射線腫瘍学会第32回学術大会
• [Presentation] Dose assessment for patients with stage ⅠNSCLC receiving carbon ion radiotherapy using daily CT images (2019)
  • Author(s): Y Li, Y Kubota, N Kubo, T Mizukami, M Sakai, H Kawamura, D Irie, N Okano, K Tsuda, JI Saitoh, T Ohno, T Nakano
  • Organizer: 日本放射線腫瘍学会第32回学術大会
• [Presentation] 前立腺がんの炭素線治療における日々の変化に対する垂直ビームと水平ビームの比較 (2019)
  • Author(s): 横山絢香、久保田佳樹、安部聖、河村英将、佐藤浩央、宮坂勇平、久保亘輝、津田和寿、須藤高行、大野達也、中野隆史
  • Organizer: 日本放射線腫瘍学会第32回学術大会
• [Presentation] 頭頸部癌重粒子線治療後の鼻涙管閉塞の解析 (2019)
  • Author(s): 久保亘輝、久保田佳樹、河村英将、酒井真理岩、岩井梨紗、今村文香、松井利晃、佐藤浩央、横尾聡、近松一郎、大野達也 央、横尾聡、近松一朗、大野達也
  • Organizer: 日本放射線腫瘍学会第32回学術大会
• [Presentation] Evaluation of intensity-, contour-based, and hybrid deformable image registration accuracy for pancreatic cancer patient images (2019)
  • Author(s): Y Kubota, M Okamoto, Y Li, S Shiba, S Okazaki, S Komatsu, M Sakai, N Kubo, T Ohno, T Nakano
  • Organizer: The 1st Annual Conference of the Asia-Oceania Particle Therapy Cooperative Group
  • Int'l Joint Research
• [Presentation] A preliminary study on adaptive carbon-ion radiotherapy with passive irradiation for pancreatic cancer (2019)
  • Author(s): Y Li, Y Kubota, M Okamoto, S Shiba, S Okazaki, S Komatsu, T Nakano, T Ohno
  • Organizer: The 1st Annual Conference of the Asia-Oceania Particle Therapy Cooperative Group
  • Int'l Joint Research
• [Presentation] Potential pitfalls of diaphragm structural matching in carbon-ion radiotherapy for pancreatic cancer (2019)
  • Author(s): Y Itabashi, Y Kubota, M Okamoto, K Tsuda, S Shiba, Y Hoshino, T Suto, T Ohno, T Nakano
  • Organizer: The 1st Annual Conference of the Asia-Oceania Particle Therapy Cooperative Group
  • Int'l Joint Research
• [Presentation] 炭素線治療における画像処理と機械学習の役割 (2019)
  • Author(s): 久保田佳樹
  • Organizer: 生体画像と医用人工知能研究会 第1回若手発表会
  • Invited
• [Presentation] 前立腺がんの炭素線治療における日々の変化に対する垂直ビームと水平ビームの直腸照射体積の評価 (2018)
  • Author(s): 横山絢香, 久保田佳樹, 安部聖, 河村英将, 岩永素太郎, 佐藤浩央, 宮坂勇平, 津田和寿, 須藤高行, 大野達也, 中野隆史.
  • Organizer: 第15回日本粒子線治療臨床研究会
• [Presentation] 肝細胞癌の重粒子線治療における横隔膜・肝臓照合の検討 (2018)
  • Author(s): 安部聖, 久保田佳樹, 横山絢香, 湯浅大智, 大橋慶明, 小鹿野友昭, 須藤高行, 渋谷圭, 大野達也, 中野隆史.
  • Organizer: 第15回日本粒子線治療臨床研究会
• [Presentation] 肺がん重粒子線治療における位置決め手法の比較 (2018)
  • Author(s): 酒井真理, 久保田佳樹, 河村英将, 武者篤, 水上達治, 久保亘輝, 岡崎祥平, 宮坂勇平, 大野達也, 中野隆史.
  • Organizer: 第15回日本粒子線治療臨床研究会
• [Presentation] 原発性肝臓がん炭素線治療における日ごと・治療中の変化に対する合算線量の評価 (2018)
  • Author(s): 久保田佳樹, 加藤弘之, 渋谷圭, 柴慎太郎, 安部聖, 酒井真理, 湯浅大智, 津田和寿, 小鹿野智明, 大野達也, 中野隆史.
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 肝臓がんの炭素線治療における日ごと・治療中の腫瘍変位に対する位置照合方法の検討 (2018)
  • Author(s): 湯浅大智, 久保田佳樹, 加藤弘之, 渋谷圭, 柴慎太郎, 安部聖, 酒井真理, 湯浅大智, 津田和寿, 小鹿野智明, 星野佳彦, 須藤高行, 大野達也, 中野隆史.
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 膵臓がんの炭素線治療における横隔膜合わせの有用性 (2018)
  • Author(s): 板橋佑典, 久保田佳樹, 岡本雅彦, 大橋慶明, 星野佳彦, 須藤高行, 大野達也, 中野隆史.
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] Accumulated Dose for Inter-fractional Anatomical Change in CIRT for Primary Hepatic Cancer. (2018)
  • Author(s): Y Kubota, H Katoh, K Shibuya, S Shiba, S Abe, M Sakai, D Yuasa, K Tsuda, T Ohno, T Nakano.
  • Organizer: International Symposium on Ion Therapy 2018
  • Int'l Joint Research
• [Presentation] Accumulated Dose for Inter-fractional Anatomical Change in CIRT for Stage I Lung Cancer (2018)
  • Author(s): Y Li, Y Kubota, T Mizukami, JI Saitoh, Y Ohashi, K Tsuda, T Ohno, T Nakano.
  • Organizer: International Symposium on Ion Therapy 2018
  • Int'l Joint Research
• [Presentation] Development of Generating High-Quality Images for Patient Positioning in Carbon-Ion Radiotherapy (2018)
  • Author(s): Y Hayama, Y Kubota, S Abe, S Souda, H Kawamura, M Torikoshi, T Ohno, T Nakano.
  • Organizer: International Symposium on Ion Therapy 2018
  • Int'l Joint Research