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Brain surgery and radiation therapy support by white matter evaluation using g-ratio

Research Project

Project/Area Number 17K09057
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionThe University of Tokyo

Principal Investigator

Suzuki Yuichi  東京大学, 医学部附属病院, 診療放射線技師 (70420221)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsg-ratio / ミエリン / 髄鞘 / MRI / 白質 / MTsaturation / NODDI / tractography / 脳疾患患者 / g-raio / 軸索 / 腫瘍鑑別 / DKI / 脳・神経 / 解剖学 / 脳神経疾患
Outline of Final Research Achievements

The g-ratio is an index of brain myelination and is used as a biomarker to indicate the degree of neural transmission, was imaged by MRI and calculated.
Although the method of imaging was used more easily than the previous study, the quantitative value was in good agreement with the study. We examined multi-modal characterization of white matter for studying language and hand motor function in healthy right-handed persons. There were significant differences about language function fiber bundles. The g-ratio was low on the left hemisphere and was shown to have less axon capacity or more myelin capacity than the right hemisphere. The g-ratio was calculated in patients with brain diseases. It was suggested that combining the two quantitative values obtained during the g-ratio calculation would improve the ability to differentiate brain tumors. Quantitative values showed some patterns in white matter near the tumor, suggesting a difference in characteristics depending on the tumor.

Academic Significance and Societal Importance of the Research Achievements

臨床MRIを用いて、かつ通常臨床の検査時間で非侵襲的に脳内白質の神経伝達速度や髄鞘化の指標であるg-ratioを計算、画像化することができた。結果、脳神経の中でも日常生活に重要な運動機能を司る運動神経と言語関連神経の左右差や特徴を把握できるようになった。また、g-ratioを算出する過程で用いる定量画像を複数組み合わせることで、脳腫瘍鑑別こ寄与できる可能性が示唆された。加えて脳疾患患者の白質に関して、定量値はいくつかのパターンを示し、疾患による特徴の差が示唆された。
今回の研究から、既存MRIでは画像化できなかった脳内白質情報や脳腫瘍性状情報を得られることが可能となった。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Advanced diffusion MRI~臨床現場で導入しやすい非正規分布拡散解析~2020

    • Author(s)
      鈴木 雄一、阿部 修
    • Journal Title

      日本磁気共鳴医学会雑誌

      Volume: 40

    • NAID

      130007908607

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Q-ball imaging tractographyにおける交叉角度閾値と錐体路描出能2019

    • Author(s)
      鈴木 雄一
    • Organizer
      日本磁気共鳴医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 「Let’s Visualize More the Brain with MRI!!」 MRIで脳内をもっと見える化してみよう!2019

    • Author(s)
      鈴木 雄一
    • Organizer
      第74回日本放射線技術学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] MagnetizationTransfer効果を用いた高分子化合物画像と拡散尖度画像を組み合わせた脳腫瘍鑑別の改善2018

    • Author(s)
      鈴木 雄一
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ミエリンおよび拡散定量パラメータを用いた言語と手指運動に関連する脳白質神経走行評価2017

    • Author(s)
      鈴木 雄一
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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