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Realistic three-dimensional virtual nodule based on spatial resolution in lung computed tomography

Research Project

Project/Area Number 17K09059
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionNiigata University

Principal Investigator

Ohkubo Masaki  新潟大学, 医歯学系, 教授 (10203738)

Co-Investigator(Kenkyū-buntansha) 成田 啓廣  新潟大学, 医歯学系, 助教 (10770208)
和田 真一  新潟大学, 医歯学系, 教授 (80105519)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsX線CT / 変調伝達関数(MTF) / 点広がり関数(PSF) / スライス感度分布(SSP) / 空間分解能 / 逐次近似再構成 / 肺がん / コンピュータ支援診断(CAD) / X線CT装置 / CT検診 / エックス線CT
Outline of Final Research Achievements

To evaluate the performance of computer-aided detection (CAD) of lung cancer CT screening, we proposed a new method for generating computer-simulated nodule images ‘virtual nodules’. The performance of a CAD system is affected by CT scanning and image reconstruction conditions. Therefore, CAD performance should be evaluated by image data obtained under the same CT conditions as those used at each site providing CT screening. The virtual nodules were generated based on the spatial resolution of a CT system used in an institution providing cancer screening and were fused into lung images obtained at that institution, allowing site-specific virtual nodules with a realistic appearance. In phantom experiments using laboratory-made physical nodules, the virtual nodules were confirmed to agree well with CT images obtained by scanning the phantom nodules. Virtual nodules can be an effective means of evaluating site-specific CAD performance.

Academic Significance and Societal Importance of the Research Achievements

肺がんの早期発見のために胸部CT検診およびコンピュータ支援診断(CAD)の普及が必要である。しかし、CADによる肺がんの検出性能はCT画像の画質に大きく依存するため、それぞれの検診施設で個別に性能を評価しなければならない。本研究で開発したVirtual Noduleは各施設の画像の空間分解能や雑音の特性を持つ結節像であることから、CADの性能を各施設が適確に評価することが可能となる。これは従来のCAD性能評価法では実現できなかったものであり、肺がんCT検診の普及につながる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] A pitfall of using the circular‐edge technique with image averaging for spatial resolution measurement in iteratively reconstructed CT images2020

    • Author(s)
      Narita Akihiro、Ohkubo Masaki
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 2 Pages: 144-151

    • DOI

      10.1002/acm2.12821

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Applications of 3D-PSF of CT Image to QA for Thoracic CT-CAD: Part 4. Application of 3D-PSF 2. Virtual Nodule Application to QA for Thoracic CT-CAD2019

    • Author(s)
      和田 真一、大久保 真樹、成田 啓廣、村尾 晃平、松本 徹、曾根 脩輔
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 39 Issue: 4 Pages: 77-85

    • DOI

      10.11323/jjmp.39.4_77

    • NAID

      130007772855

    • ISSN
      1345-5354, 2186-9634
    • Year and Date
      2019-12-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Applications of 3D-PSF of CT Image to QA for Thoracic CT-CAD: Part 3. Application of 3D-PSF 1. Conversion and Normalization of the Spatial Resolution of CT Image2019

    • Author(s)
      和田 真一、大久 保真樹、成田 啓廣、村尾 晃平、松本 徹
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 39 Issue: 3 Pages: 61-67

    • DOI

      10.11323/jjmp.39.3_61

    • NAID

      130007739860

    • ISSN
      1345-5354, 2186-9634
    • Year and Date
      2019-10-31
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Applications of 3D-PSF of CT Image to QA for Thoracic CT-CAD: Part 2. Application of 3D-PSF and Verification of Measurement Accuracy of PSF2019

    • Author(s)
      和田 真一、大久 保真樹、成田 啓廣、村尾 晃平、松本 徹
    • Journal Title

      Japanese Journal of Medical Physics (Igakubutsuri)

      Volume: 39 Issue: 2 Pages: 42-49

    • DOI

      10.11323/jjmp.39.2_42

    • NAID

      130007699211

    • ISSN
      1345-5354, 2186-9634
    • Year and Date
      2019-08-31
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of realistic virtual nodules based on three-dimensional spatial resolution in lung computed tomography: A pilot phantom study2017

    • Author(s)
      Narita Akihiro、Ohkubo Masaki、Murao Kohei、Matsumoto Toru、Wada Shinichi
    • Journal Title

      Medical Physics

      Volume: 44 Issue: 10 Pages: 5303-5313

    • DOI

      10.1002/mp.12503

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] A feasible approach to correct MTF measured by the circular-edge method with image averaging in iterative reconstruction CT2020

    • Author(s)
      Ishizaka Natsuki、Narita Akihiro、Ohkubo Masaki
    • Organizer
      第119回医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A simple method for generating metal artifacts on CT image using forward projection2020

    • Author(s)
      Mugishima Daisuke、Narita Akihiro、Ohkubo Masaki
    • Organizer
      第119回医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A method for evaluating the detrending technique in noise power spectrum measurements with a simplified CT image simulation2020

    • Author(s)
      Okamoto Kazuki、Narita Akihiro、Ohkubo Masaki
    • Organizer
      第119回医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 逐次近似再構成CT画像における球体ファントムを用いたslice sensitivity profile(SSP)の測定2020

    • Author(s)
      深谷貴広、成田 啓廣、大久保真樹
    • Organizer
      日本放射線技術学会第76回総会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Determination of point spread function accompanied with verification in iterative reconstruction computed tomography2019

    • Author(s)
      Sakai Ken、Ohkubo Masaki、Narita Akihiro
    • Organizer
      第117回医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Computational simulation of metal artifact generation in CT image: A pilot phantom study2019

    • Author(s)
      Mugishima Daisuke、Narita Akihiro、Ohkubo Masaki
    • Organizer
      第117回医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Determination of point spread function accompanied with verification in iterative reconstruction computed tomography2019

    • Author(s)
      Sakai K, Ohkubo M, Narita A
    • Organizer
      第117回医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Computational simulation of metal artifact generation in CT image: A pilot phantom study2019

    • Author(s)
      Mugishima D, Narita A, Ohkubo M
    • Organizer
      第117回医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Determination of slice sensitivity profile for iterative reconstruction CT using low-contrast phantom2018

    • Author(s)
      Harashima S, Ohkubo M, Narita A
    • Organizer
      第115回医学物理学会学術大会
    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Presentation] CT装置における逐次近似再構成法での低コントラストファントムを用いたSSP決定法2018

    • Author(s)
      原嶋 真吾、成田 啓廣、大久保 真樹、和田 真一
    • Organizer
      第25回日本CT検診学会
    • Related Report
      2017 Research-status Report
  • [Presentation] CAD-quality assuranceのためのSite-specificな疑似肺結節像生成法の研究2018

    • Author(s)
      成田 啓廣、大久保 真樹、村尾 晃平、松本 徹、和田 真一
    • Organizer
      第25回日本CT検診学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Virtual noduleを用いた胸部CT-CADの性能特性評価の研究:nodule性状の変化に対する3機種CADの応答2018

    • Author(s)
      舩越 萌香、郷戸 充、大久保 真樹、成田 啓廣、村尾 晃平、松本 徹、和田 真一、村松 禎久
    • Organizer
      第25回日本CT検診学会
    • Related Report
      2017 Research-status Report
  • [Remarks] 新潟大学医学部保健学科大学院保健学研究科 研究紹介

    • URL

      http://www1.clg.niigata-u.ac.jp/kenkyuka/kenkyu-shokai/#2

    • Related Report
      2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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