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A direct range visualization method by C-10 3-gamma Compton-PETfor C-ion therapy

Research Project

Project/Area Number 17K09076
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

Mohammadi Akram  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 先進核医学基盤研究部, 主任研究員(任常) (10554735)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords粒子線治療学 / Compton PET / triple gamma-ray imaging / visualization of C-10 / PET / Compton camera
Outline of Final Research Achievements

In heavy ion therapy, where the cancer treatment using heavy ions has significant advantages, verification of the ion rage inside the patient’s body is an important issue. In this study, we focused on detection of C-10 nuclide, which emits a positron and a single gamma ray at the same time, by combining the PET and Compton camera Methods. First the feasibility of proposed method was checked by performing Monte Carlo simulation and then we made a small-scale prototype of the device (whole-gamma imaging (WGI)) and conducted a demonstration experiment at the HIMAC secondary beam port.

Academic Significance and Societal Importance of the Research Achievements

The major advantage of heavy ion therapy is a good dose localization and it is desirable to reduce range ambiguities in treatment planning for making full use of the major advantage. We developed a range verification system using C-10 beams to verify the ranges in patients directly.

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Influence of momentum acceptance on range monitoring of 11C and 15O ion beams using in-beam PET2020

    • Author(s)
      Akram Mohammadi, Hideaki Tashima, Yuma Iwao, Sodai Takyu, Go Akamatsu, Han Gyu Kang, Fumihiko Nishikido, Eiji Yoshida, Andrew Chacon, Mitra Safavi-Naeini, Katia Parodi and Taiga Yamaya
    • Journal Title

      Physics in Medicine & Biology

      Volume: 65 Issue: 12 Pages: 125006-125006

    • DOI

      10.1088/1361-6560/ab8059

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Compton-PET Imaging of 10C for Range Verification of Carbon Ion Therapy2019

    • Author(s)
      Akram Mohammadi
    • Journal Title

      2018 IEEE Nuclear Science Symposium and Medical Imaging Conference Proceedings (NSS/MIC)

      Volume: - Pages: 1-3

    • DOI

      10.1109/nssmic.2018.8824325

    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Feasibility of Compton-PET to image C-10 distribution for range verification of carbon ion therapy2019

    • Author(s)
      Akram Mohammadi
    • Journal Title

      第11回日本医学物理学会学術大会会報文集

      Volume: 39 Pages: 134-134

    • Related Report
      2019 Research-status Report
  • [Presentation] Optimization of the surface area of the laser-induced layer for DOI detectors with high spatial resolution2020

    • Author(s)
      Akram Mohammadi
    • Organizer
      NSS MIC 2020 Nuclear Science Symposium Medical Imaging Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility of Compton-PET to image C-10 distribution for range verification of carbon ion therapy2019

    • Author(s)
      Akram Mohammadi
    • Organizer
      第11回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Compton-PET imaging of 10C for Range Verification of Carbon Ion Therapy2018

    • Author(s)
      Akram Mohammadi
    • Organizer
      NSS-MIC 2018 (2018 IEEE Nuclear Science Symposium and Medical Imaging Conference)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Potential of Radioactive Ion Beams for Therapy and PET imaging2017

    • Author(s)
      Mohammadi Akram
    • Organizer
      NSS-MIC 2017 (2017 IEEE Nuclear Science Symposium and Medical Imaging Conference)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Range verification of O-15 beam using OpenPET2017

    • Author(s)
      Mohammadi Akram
    • Organizer
      PTCOG56 (56th Annual Conference of the Particle Therapy Co-Operative Group
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-01-27  

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