Clinical effectiveness of four-dimensional dose distribution calculation for a tracking irradiation

• Project/Area Number: 17K09078
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Tachibana Hidenobu 国立研究開発法人国立がん研究センター, 先端医療開発センター, 医学物理専門職 (20450215)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 四次元計算 / 線量計算 / 非剛体レジストレーション / 線量計算エンジン / 線量計算アルゴリズム / 高速度 / GPGPU

Outline of Final Research Achievements

We developed a dose calculation engine and a non-rigid registration engine, which are two important points in the development of a quality assurance system using four-dimensional dose calculation. The Collapse Cone Convolution Algorithm was adopted as the dose calculation engine and implemented. As a result, it was confirmed that the calculation accuracy was equivalent to that of the treatment planning device. On the other hand, it was found that the calculation time of this program was very long, and this speedup was decided to be carried over to 2020. Acceleration of non-rigid registration has been completed. Development of a GUI that integrates these two points has been completed. In FY2020, the development of a quality assurance system using four-dimensional dose calculation will be completed, and its effectiveness will be verified.

Academic Significance and Societal Importance of the Research Achievements

放射線治療の新しい技術として動いている腫瘍を追尾して照射する追尾照射がある。通常の照射方では腫瘍の外の正常臓器へも照射する必要があるが、追尾照射方法は腫瘍の周りの正常臓器を極力打たなくて済む。したがって、副作用が小さく、また腫瘍への線量増加が可能で腫瘍制御率の向上が期待できる。
一方、複雑な治療法であり、実際治療計画の際は実際の患者体内の線量分布を確認できていない。そこで、その追尾照射を確認できる方法である四次元線量計算を利用した品質保証システムの開発を行った。このシステムにより不明であった追尾照射の線量分布が明らかになり、さらなる治療法の向上が見込める。

Research Products

• [Journal Article] 2018 AAPM Annual Meeting (2019)
  • Author(s): 橘 英伸
  • Journal Title: Japanese Journal of Medical Physics (Igakubutsuri) Volume: 38 Issue: 4 Pages: 174-176
  • DOI: 10.11323/jjmp.38.4_174
  • NAID: 130007606666
  • ISSN: 1345-5354, 2186-9634
  • Year and Date: 2019-02-28
• [Journal Article] Liver phantom design and dosimetric verification in participating institutions for a proton beam therapy in patients with resectable hepatocellular carcinoma: Japan Clinical Oncology Group trial (JCOG1315C) (2019)
  • Author(s): Nishio T, Tachibana H, Kase Y, Hotta K, Nakamura M, Tamura M, Terunuma T, Toshito T, Yamashita H, Ishikura S, Fuji H, Akimoto T, Nishimura Y.
  • Journal Title: Radiother Oncol. Volume: 29 Pages: 98-104
  • DOI: 10.1016/j.radonc.2019.06.005
  • Peer Reviewed
• [Journal Article] A multi-institutional study of independent calculation verification in inhomogeneous media using a simple and effective method of heterogeneity correction integrated with the Clarkson method (2018)
  • Author(s): Jinno Shunta、Tachibana Hidenobu、Moriya Shunsuke、Mizuno Norifumi、Takahashi Ryo、Kamima Tatsuya、Ishibashi Satoru、Sato Masanori
  • Journal Title: Journal of Radiation Research Volume: 59 Issue: 4 Pages: 490-500
  • DOI: 10.1093/jrr/rry039
  • Peer Reviewed / Open Access
• [Journal Article] Multi-institutional comparison of computer-based independent dose calculation for intensity modulated radiation therapy and volumetric modulated arc therapy (2018)
  • Author(s): Kamima Tatsuya、Baba Hiromi、Takahashi Ryo、Yamashita Mikiko、Sugawara Yasuharu、Kawai Daisuke、Yamamoto Toshijiro、Satou Aya、Tachibana Hidenobu
  • Journal Title: Physica Medica Volume: 45 Pages: 72-81
  • DOI: 10.1016/j.ejmp.2017.10.024
  • Peer Reviewed
• [Journal Article] Design and development of a nonrigid phantom for the quantitative evaluation of DIR-based mapping of simulated pulmonary ventilation (2018)
  • Author(s): Miyakawa Shin、Tachibana Hidenobu、Moriya Shunsuke、Kurosawa Tomoyuki、Nishio Teiji、Sato Masanori
  • Journal Title: Medical Physics Volume: 45 Issue: 8 Pages: 3496-3505
  • DOI: 10.1002/mp.13017
  • Peer Reviewed
• [Journal Article] A multi-institutional study of secondary check of treatment planning using Clarkson-based dose calculation for three-dimensional radiotherapy (2018)
  • Author(s): Takahashi Ryo、Kamima Tatsuya、Itano Masanobu、Yamazaki Takeshi、Ishibashi Satoru、Higuchi Yoshihiro、Shimizu Hiroyuki、Yamamoto Toshijiro、Yamashita Mikiko、Baba Hiromi、Sugawara Yasuharu、Sato Aya、Nishiyama Shiro、Kawai Daisuke、Miyaoka Satoshi、Tachibana Hidenobu
  • Journal Title: Physica Medica Volume: 49 Pages: 19-27
  • DOI: 10.1016/j.ejmp.2018.04.394
  • Peer Reviewed
• [Journal Article] Evaluation of deformation parameters for deformable image registration-based ventilation imaging using an air-ventilating non-rigid phantom (2018)
  • Author(s): Miyakawa Shin、Tachibana Hidenobu、Moriya Shunsuke、Kurosawa Tomoyuki、Nishio Teiji
  • Journal Title: Physica Medica Volume: 50 Pages: 20-25
  • DOI: 10.1016/j.ejmp.2018.05.016
  • Peer Reviewed
• [Journal Article] Impact of shoulder deformation on volumetric modulated arc therapy doses for head and neck cancer (2018)
  • Author(s): Tachibana Hidenobu、Motegi Kana、Moriya Shunsuke
  • Journal Title: Physica Medica Volume: 53 Pages: 118-128
  • DOI: 10.1016/j.ejmp.2018.08.015
  • Peer Reviewed
• [Journal Article] An end-to-end postal audit test to examine the coincidence between the imaging isocenter and treatment beam isocenter of the IGRT linac system for Japan Clinical Oncology Group (JCOG) clinical trials (2018)
  • Author(s): Kumazaki Yu、Ozawa Shuichi、Nakamura Mitsuhiro、Kito Satoshi、Minemura Toshiyuki、Tachibana Hidenobu、Nishio Teiji、Ishikura Satoshi、Nishimura Yasumasa
  • Journal Title: Physica Medica Volume: 53 Pages: 145-152
  • DOI: 10.1016/j.ejmp.2018.08.010
  • Peer Reviewed
• [Journal Article] Multi-institutional comparison of secondary check of treatment planning using computer-based independent dose calculation for non-C-arm linear accelerators (2018)
  • Author(s): Tachibana Hidenobu、Uchida Yukihiro、Miyakawa Ryuta、Yamashita Mikiko、Sato Aya、Kito Satoshi、Maruyama Daiki、Noda Shigetoshi、Kojima Toru、Fukuma Hiroshi、Shirata Ryosuke、Okamoto Hiroyuki、Nakamura Mitsuhiro、Takada Yuma、Nagata Hironori、Hayashi Naoki、Takahashi Ryo、Kawai Daisuke、Itano Masanobu
  • Journal Title: Physica Medica Volume: 56 Pages: 58-65
  • DOI: 10.1016/j.ejmp.2018.11.011
  • Peer Reviewed
• [Journal Article] Range optimization for target and organs at risk in dynamic adaptive passive scattering proton beam therapy ? A proof of concept (2018)
  • Author(s): Moriya Shunsuke、Tachibana Hidenobu、Hotta Kenji、Nakamura Naoki、Sakae Takeji、Akimoto Tetsuo
  • Journal Title: Physica Medica Volume: 56 Pages: 66-73
  • DOI: 10.1016/j.ejmp.2018.11.010
  • Peer Reviewed
• [Journal Article] Usefulness of hybrid deformable image registration algorithms in prostate radiation therapy (2018)
  • Author(s): Motegi Kana、Tachibana Hidenobu、Motegi Atsushi、Hotta Kenji、Baba Hiromi、Akimoto Tetsuo
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: 20 Issue: 1 Pages: 229-236
  • DOI: 10.1002/acm2.12515
  • Peer Reviewed / Open Access
• [Journal Article] Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma (2017)
  • Author(s): Hirano Y, Onozawa M, Hojo H, Motegi A, Zenda S, Hotta K, Moriya S, Tachibana H, Nakamura N, Kojima T, Akimoto T
  • Journal Title: Radiat Oncol Volume: 13(1) Issue: 1 Pages: 474-4481
  • DOI: 10.1186/s13014-018-0966-5
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of a new online patient-specific quality assurance system for respiratory-gated radiotherapy (2017)
  • Author(s): Kurosawa Tomoyuki、Tachibana Hidenobu、Moriya Shunsuke、Miyakawa Shin、Nishio Teiji、Sato Masanori
  • Journal Title: Physica Medica Volume: 43 Pages: 63-72
  • DOI: 10.1016/j.ejmp.2017.10.011
  • Peer Reviewed
• [Journal Article] Effectiveness of a simple and real-time baseline shift monitoring system during stereotactic body radiation therapy of lung tumors (2017)
  • Author(s): Uchida Yukihiro、Tachibana Hidenobu、Kamei Yoshiyuki、Kashihara Kenichi
  • Journal Title: Physica Medica Volume: 43 Pages: 100-106
  • DOI: 10.1016/j.ejmp.2017.11.001
  • Peer Reviewed
• [Journal Article] Prognostic factors associated with the accuracy of deformable image registration in lung cancer patients treated with stereotactic body radiotherapy (2017)
  • Author(s): Sugawara Yasuharu、Tachibana Hidenobu、Kadoya Noriyuki、Kitamura Nozomi、Sawant Amit、Jingu Keiichi
  • Journal Title: Medical Dosimetry Volume: 42 Issue: 4 Pages: 326-333
  • DOI: 10.1016/j.meddos.2017.07.004
  • Peer Reviewed
• [Journal Article] Dose warping performance in deformable image registration in lung (2017)
  • Author(s): Moriya Shunsuke、Tachibana Hidenobu、Kitamura Nozomi、Sawant Amit、Sato Masanori
  • Journal Title: Physica Medica Volume: 37 Pages: 16-23
  • DOI: 10.1016/j.ejmp.2017.03.016
  • Peer Reviewed
• [Presentation] ガンマ評価におけるRadiomicsを利用したIMRT患者検証におけるMLCエラーの検出 (2019)
  • Author(s): 橘英伸
  • Organizer: 第３２回高精度放射線外部照射部会学術大会
• [Presentation] Usefulness of quantitative assessment tool of anatomical change using a virtual proton depth radiograph for adaptive proton therapy (2018)
  • Author(s): 橘英伸
  • Organizer: 第１１５回日本医学物理学会学術大会
• [Presentation] Long SSD法を用いたCTベース治療計画での全身照射の包括的なアプローチ (2018)
  • Author(s): 橘英伸
  • Organizer: 第１１５回日本医学物理学会学術大会
• [Presentation] What Did a Large Cohort Study for Clarkson-Type Secondary Check Find? (2018)
  • Author(s): Hidenobu Tachibana
  • Organizer: AAPM2018
  • Int'l Joint Research
• [Presentation] AAPMタスクグループ２１８（AAPM TG218）レポートから見たIMRT-QAツールの妥当性評価 (2018)
  • Author(s): 橘英伸
  • Organizer: 日本放射線腫瘍学会第３１回学術大会
• [Presentation] 強度変調の複雑性スコアを利用した治療計画の品質の評価 (2018)
  • Author(s): 橘英伸
  • Organizer: 日本放射線腫瘍学会第３１回学術大会