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Factors related to elevated serum immunoglobulin G4 (IgG4) levels and development of IgG4-related disease in a Japanese general population

Research Project

Project/Area Number 17K09083
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionKanazawa University

Principal Investigator

FUJII HIROSHI  金沢大学, 医学系, 協力研究員 (20596895)

Co-Investigator(Kenkyū-buntansha) 田嶋 敦  金沢大学, 医学系, 教授 (10396864)
川野 充弘  金沢大学, 附属病院, 講師 (20361983)
中村 裕之  金沢大学, 医学系, 教授 (30231476)
水島 伊知郎  金沢大学, 附属病院, 助教 (50645124)
山田 和徳  金沢医科大学, 医学部, 准教授 (90397224)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsIgG4関連疾患 / IgG4 / 予防医学 / 環境 / 疫学
Outline of Final Research Achievements

This study aimed to investigate the frequency of elevated serum IgG4 level in the general Japanese population and its associated factors. We measured the serum IgG4 in 1,201 residents in Ishikawa prefecture. Logistic regression analysis was used to search for factors related to elevated serum IgG4 levels. The mean serum IgG4 level was 44 mg/dL, and elevated serum IgG4 levels were observed in 42 patients. Logistic regression analyses showed that male sex, older age, and less intake of lipid and polyunsaturated fatty acids and more intake of carbohydrate in daily diet were associated with elevated serum IgG4 levels. Subgroup analyses in men showed that older age, lower estimated glomerular filtration rates based on serum cystatin C (eGFR-cysC) levels, and higher hemoglobin A1c levels were associated with elevated serum IgG4 levels. Among cases with high IgG4 level, one of the 14 residents was diagnosed with possible IgG4-related retroperitoneal fibrosis.

Academic Significance and Societal Importance of the Research Achievements

IgG4関連疾患の罹患率は10万人に0.28~1.08人と試算されていた。しかしながら今回の研究では1201名の検討で1名のIgG4RD疑い症例を認めており、実際はもっと頻度の高い疾患であると考えられる。また、脂質と不飽和脂肪酸の摂取減少、炭水化物の摂取増加、HbA1cがIgG4高値が関連することを示した初めての研究であり、動脈硬化との関連について示唆的な結果を得ることができた。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 7 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Renal Involvement in Retroperitoneal Fibrosis: Prevalence, Impact and Management Challenges2021

    • Author(s)
      Mizushima Ichiro、Kawano Mitsuhiro
    • Journal Title

      International Journal of Nephrology and Renovascular Disease

      Volume: Volume 14 Pages: 279-289

    • DOI

      10.2147/ijnrd.s239160

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease2021

    • Author(s)
      Mizushima Ichiro、Konishi Masahiro、Sanada Hajime、Suzuki Kazuyuki、Takeji Akari、Zoshima Takeshi、Hara Satoshi、Ito Kiyoaki、Fujii Hiroshi、Yamada Kazunori、Kawano Mitsuhiro
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 13341-13341

    • DOI

      10.1038/s41598-021-92814-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of two or more sets of lacrimal glands and/or major salivary glands is related to greater systemic disease activity due to multi-organ involvement in IgG4-related dacryoadenitis/sialadenitis2021

    • Author(s)
      Takahashi Y, Mizushima I, Konishi M, Kawahara H, Sanada H, Suzuki K, Takeji A, Hara S, Ito K, Fujii H, Kawano M.
    • Journal Title

      Mod Rheumatol.

      Volume: 11 Issue: 6 Pages: 1-10

    • DOI

      10.1080/14397595.2021.1878623

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positive disease-specific autoantibodies have limited clinical significance in diagnosing IgG4-related disease in daily clinical practice2020

    • Author(s)
      Ichiro Mizushima 1, Takahiro Yamano 1, Hiroyuki Kawahara 1, Shinya Hibino 1, Ryo Nishioka 1, Takeshi Zoshima 1, Satoshi Hara 1, Kiyoaki Ito 1, Hiroshi Fujii 1, Hideki Nomura 2, Mitsuhiro Kawano 1
    • Journal Title

      Rheumatology (Oxford)

      Volume: 12 Issue: 7 Pages: 3317-3325

    • DOI

      10.1093/rheumatology/keaa783

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypocomplementemia is related to elevated serum levels of IgG subclasses other than IgG4 in IgG4-related kidney disease.2020

    • Author(s)
      Fujisawa Y, Mizushima I, Yamada K, Yamamoto M, Saeki T, Matsui S, Tsuge S, Hara S, Ito K, Fujii H, Takahashi H, Nomura H, Kawa S, Kawano M.
    • Journal Title

      Mod Rheumatol.

      Volume: 13 Issue: 1 Pages: 1-8

    • DOI

      10.1080/14397595.2019.1709942

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different factors underlie recurrent and de novo organ involvement in immunoglobulin G4-related disease.2020

    • Author(s)
      Mizushima I, Tsuge S, Fujisawa Y, Hara S, Suzuki F, Ito K, Fujii H, Yamada K, Kawano M.
    • Journal Title

      Rheumatology (Oxford).

      Volume: 59 Pages: 513-518

    • DOI

      10.1093/rheumatology/kez321

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abundant a proliferation-inducing ligand (APRIL)-producing macrophages contribute to plasma cell accumulation in immunoglobulin G4-related disease2018

    • Author(s)
      Kawakami Takahiro、Mizushima Ichiro、Yamada Kazunori、Fujii Hiroshi、Ito Kiyoaki、Yasuno Tetsuhiko、Izui Shozo、Yamagishi Masakazu、Huard Bertrand、Kawano Mitsuhiro
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 15 Issue: 6 Pages: 960-969

    • DOI

      10.1093/ndt/gfy296

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A case of IgG4-related kidney disease with predominantly unilateral renal atrophy2018

    • Author(s)
      Takeji Akari、Yamada Kazunori、Inoue Dai、Mizushima Ichiro、Hara Satoshi、Ito Kiyoaki、Fujii Hiroshi、Nakajima Kenichi、Mizutomi Kazuaki、Yamagishi Masakazu、Kawano Mitsuhiro
    • Journal Title

      CEN Case Reports

      Volume: 8 Issue: 1 Pages: 8-13

    • DOI

      10.1007/s13730-018-0355-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of double positive for anti-centromere and anti-SS-a/Ro antibodies on clinicopathological characteristics of primary Sjogren’s syndrome: a retrospective cohort study2018

    • Author(s)
      Suzuki Yasunori、Fujii Hiroshi、Nomura Hideki、Mizushima Ichiro、Yamada Kazunori、Yamagishi Masakazu、Kawano Mitsuhiro
    • Journal Title

      Modern Rheumatology

      Volume: 28 Issue: 5 Pages: 872-878

    • DOI

      10.1080/14397595.2017.1418164

    • Related Report
      2018 Research-status Report
  • [Journal Article] Changes in serum interleukin-6 levels as possible predictor of efficacy of tocilizumab treatment in rheumatoid arthritis2018

    • Author(s)
      Aizu Motohiko、Mizushima Ichiro、Nakazaki Satoshi、Nakashima Akikatsu、Kato Takashi、Murayama Takashi、Kato Shinichi、Katsuki Yasuo、Ogane Kunihiro、Fujii Hiroshi、Yamada Kazunori、Nomura Hideki、Yachie Akihiro、Yamagishi Masakazu、Kawano Mitsuhiro
    • Journal Title

      Modern Rheumatology

      Volume: 28 Issue: 4 Pages: 592-598

    • DOI

      10.1080/14397595.2017.1370766

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Factors related to serum IgG4 elevation and development of IgG4-related disease: data from resident examination2022

    • Author(s)
      Shunsuke tsuge
    • Organizer
      EULAR 2022 Congress
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血清 IgG4 値正常の IgG4 関連疾患の特徴2021

    • Author(s)
      道谷直樹、藤井博、水島伊知郎、川野充弘
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 顎下リンパ節病変のみと考えられたIgG4関連リンパ節症の一例2021

    • Author(s)
      春藤英明、藤井博、水島伊知郎、川野充弘
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 本邦における環境要素および併存疾患が血清IgG4及びIgG4関連疾患に与える影響について2019

    • Author(s)
      川野 充弘・藤井 博
    • Organizer
      第26回ファイザーヘルスリサーチフォーラム
    • Related Report
      2019 Research-status Report
  • [Presentation] 一般住民における食事内容と自己抗体出現の関連についての調査2019

    • Author(s)
      藤井 博、水島 伊知郎、山田 和徳、川野 充弘 他
    • Organizer
      第63回日本リウマチ学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 無治療のIgG4関連疾患患者における疾患増悪に関連する因子の検討2019

    • Author(s)
      水島 伊知郎、藤井 博、山田 和徳、川野 充弘 他
    • Organizer
      第63回日本リウマチ学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 膠原病合併関節リウマチ患者に対するアバタセプトの有用性の検討2019

    • Author(s)
      山田 和徳、水島 伊知郎、藤井 博、川野 充弘 他
    • Organizer
      第63回日本リウマチ学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 環境要素および併存疾患が血清IgG4及びIgG4関連疾患に与える影響について2018

    • Author(s)
      藤井 博
    • Organizer
      第62回日本リウマチ学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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