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Research for cerebrovascular disease-related conditions

Research Project

Project/Area Number 17K09084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionNational Cardiovascular Center Research Institute (2018-2023)
Osaka University (2017)

Principal Investigator

Kaori Miwa  国立研究開発法人国立循環器病研究センター, 病院, 医長 (80645341)

Co-Investigator(Kenkyū-buntansha) 坂口 学  大阪大学, 大学院医学系研究科, 招へい教員 (70432474)
藤堂 謙一  大阪大学, 医学部附属病院, 助教 (40403068)
大山 直紀  大阪大学, 医学系研究科, 特任研究員 (90622895)
佐々木 勉  大阪大学, 大学院医学系研究科, 特任教授(常勤) (20534879)
高杉 純司  大阪大学, 医学部附属病院, 助教 (40796033)
権 泰史  大阪大学, 医学部附属病院, 特任講師(常勤) (70751311)
Project Period (FY) 2017-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordscerebrovascular disease / cotnitive impairment / disability / 脳小血管病 / 脳卒中 / ラクナ梗塞 / 認知機能障害 / 認知機能検査 / 急性期脳卒中 / 認知機能 / バイオバンク / 急性期脳梗塞 / 血栓溶解療法 / 脳血管障害 / 認知機能低下 / 社会医学 / 臨床疫学
Outline of Final Research Achievements

Cerebrovascular disorders encompass a diverse range of pathologies and include stroke and cerebral small vessel disease. As they are all associated with physical disability, death, and cognitive impairment, the development of interventions to prevent the onset and severity of disease is an urgent issue.
From registered registry data, this study reports an association between BMI and functional prognosis in stroke patients, and between cerebral small vessel disease and cognitive decline in patients with impaired renal function.

Academic Significance and Societal Importance of the Research Achievements

近年における脳血管障害の機能的予後や認知機能障害について、関連する因子を検証した。修正可能な因子であるBMIや腎機能低下に注目し、最近の知見を纏めた。

Report

(8 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2024 2022 2021 2019

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (2 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Clinical impact of body mass index on outcomes of ischemic and hemorrhagic strokes2024

    • Author(s)
      Kaori Miwa, Michikazu Nakai, Sohei Yoshimura, Yusuke Sasahara, Shinichi Wada, Junpei Koge, Akiko Ishigami, Yoshiki Yagita, Kenji Kamiyama, Yoshihiro Miyamoto, Shotai Kobayashi, Kazuo Minematsu, Kazunori Toyoda, Masatoshi Koga
    • Journal Title

      International Journal of Stroke

      Volume: - Issue: 8 Pages: 907-915

    • DOI

      10.1177/17474930241249370

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management of Emerging or Unconventional Risk Factors-22024

    • Author(s)
      Kaori Miwa, Kazunori Toyoda
    • Journal Title

      Ischemic Stroke Therapeutics

      Volume: - Pages: 141-149

    • DOI

      10.1007/978-3-031-49963-0_12

    • ISBN
      9783031499623, 9783031499630
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Etiology and Outcome of Ischemic Stroke in Patients With Renal Impairment Including Chronic Kidney Disease: Japan Stroke Data Bank2022

    • Author(s)
      Kaori Miwa 1, Masatoshi Koga 1, Michikazu Nakai 1, Sohei Yoshimura 1, Yusuke Sasahara 1, Junpei Koge 1, Kazutaka Sonoda 1, Akiko Ishigami 1, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Shotai Kobayashi, Kazuo Minematsu, Kazunori Toyoda, Japan Stroke Data Bank Investigators
    • Journal Title

      Neurology

      Volume: 98 Issue: 17

    • DOI

      10.1212/wnl.0000000000200153

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Heart Rate Variabilities on Outcome After Acute Intracerebral Hemorrhage: A Post Hoc Analysis of ATACH-22021

    • Author(s)
      Kaori Miwa, Masatoshi Koga, Mayumi Fukuda-Doi, Haruko Yamamoto, Kanata Tanaka, Sohei Yoshimura, Masafumi Ihara, Adnan I Qureshi, Kazunori Toyoda
    • Journal Title

      J Am Heart Assoc

      Volume: 10 Issue: 16

    • DOI

      10.1161/jaha.120.020364

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebral microbleeds development after stroke thrombolysis: A secondary analysis of the THAWS randomized clinical trial2021

    • Author(s)
      Kaori Miwa, Masatoshi Koga, Manabu Inoue, Sohei Yoshimura, Makoto Sasaki, Yusuke Yakushiji, Mayumi Fukuda-Doi, Yasushi Okada, Taizen Nakase, Masafumi Ihara, Yoshinari Nagakane, Shunya Takizawa, Koko Asakura, Junya Aoki, Kazumi Kimura, Haruko Yamamoto, Kazunori Toyoda
    • Journal Title

      Int J Stroke

      Volume: - Issue: 6 Pages: 628-636

    • DOI

      10.1177/17474930211035023

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A 9-Year Longitudinal Study of Basilar Artery Diameter2019

    • Author(s)
      Takeuchi M, Miwa K, Tanaka M, Zhou Y, Todo K, Sasaki T, Sakaguchi M, Kitagawa K, Mochizuki H.
    • Journal Title

      J Am Heart Assoc.

      Volume: 8 Issue: 5

    • DOI

      10.1161/jaha.118.011154

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] CKD 患者の認知症の特徴2024

    • Author(s)
      三輪佳織
    • Organizer
      第14回日本腎臓リハビリテーション学会学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 高血圧性脳小血管病(1型脳小血管病)と認知症2022

    • Author(s)
      三輪佳織
    • Organizer
      第41回日本認知症学会学術集会 第37回日本老年精神医学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Book] Ischemic Stroke Therapeutics2024

    • Author(s)
      Bruce Ovbiagele, Anthony S. Kim
    • Total Pages
      488
    • Publisher
      Springer, Cham
    • ISBN
      9783031499623
    • Related Report
      2023 Annual Research Report

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Published: 2017-04-28   Modified: 2025-01-30  

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