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Association between HHV-6 infection and cognitive functioning in patients receiving allogeneic hematopoietic stem cell transplantation

Research Project

Project/Area Number 17K09090
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionOita University

Principal Investigator

Ogata Masao  大分大学, 医学部, 講師 (10332892)

Co-Investigator(Kenkyū-buntansha) 河野 利恵  大分大学, 医学部, 病院特任助教 (20468002)
稲垣 正俊  島根大学, 学術研究院医学・看護学系, 教授 (60415510)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsヒトヘルペスウイルス6 / 認知機能 / quality of life / 集中力 / 観察研究 / 同種造血幹細胞移植 / Quality of life / ヒトヘルペスウイスス6 / ウィルス / 脳・神経 / 臨床疫学 / HHV-6
Outline of Final Research Achievements

HHV-6 is a herpes virus that is latently infectious in all adults. We designed this study because HHV-6 reactivation may potentially impair the central nervous system of transplant recipients. In an interim analysis, we found a high incidence of impaired attention and concentration and disorientation, consistent with HHV-6 reactivation, suggesting that HHV-6 reactivation causes acute dysfunction of central nervous system functions in many cases, even in those without clinically diagnosed encephalitis.

Academic Significance and Societal Importance of the Research Achievements

本研究はHHV-6が移植患者に対し潜在的に中枢神経機能障害を高頻度にきたし、これが認知機能障害、記憶能力や処理能力の低下、およびQOL低下につながっている可能性を示した。このことは、ウイルス再活性化の抑制が認知機能障害の予防につながる可能性を示しており、意義が大きい。HHV-6にはホスカルネットなどの抗ウイルス薬がその再活性化抑制に有効である。現時点で長期 (移植1年後)にわたる評価が終了していないが、その結果により認知機能障害を目的とした介入試験につながると考えている。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (19 results)

All 2021 2020 2019 2018 2017

All Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Retrospective case analysis of antiviral therapies for HHV‐6 encephalitis after hematopoietic stem cell transplantation2021

    • Author(s)
      Toomey Danny、Phan Tuan L.、Nguyen Vanessa、Phan Thommas T.、Ogata Masao
    • Journal Title

      Transplant Infectious Disease

      Volume: 23 Issue: 1

    • DOI

      10.1111/tid.13443

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 同種造血幹細胞移植後human herpesvirus 6B脳炎: 知っておきたいこと2020

    • Author(s)
      緒方正男
    • Journal Title

      日本造血細胞移植学会雑誌

      Volume: 6 Pages: 77-82

    • NAID

      130007873350

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 移植後HHV-6B脳炎2020

    • Author(s)
      緒方 正男
    • Journal Title

      臨床血液

      Volume: 61 Pages: 945-952

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical practice recommendations for the diagnosis and management of human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation: the Japan Society for Hematopoietic Cell Transplantation.2019

    • Author(s)
      Ogata M, Uchida N, Fukuda T, Ikegame K, Kamimura T, Onizuka M, Kato K, Kobayashi H, Sasahara Y, Sawa M, Sawada A, Hasegawa D, Masuko M, Miyamoto T, Okamoto S.
    • Journal Title

      Bone Marrow Transplant.

      Volume: -- Issue: 6 Pages: 1004-1013

    • DOI

      10.1038/s41409-019-0752-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlations of cytokine levels in cerebrospinal fluid and peripheral blood with outcome of HHV-6B encephalitis after hematopoietic stem cell transplantation.2019

    • Author(s)
      Takano K, Ogata M, Satou T, Miyazaki Y, Otsuka E, Saito N, Ueki T, Kako S, Fukuda T, Shirao K
    • Journal Title

      Transpl Infect Dis

      Volume: 21 Issue: 6

    • DOI

      10.1111/tid.13172

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antiviral therapy for the treatment of HHV-6-associated syndromes after transplant2018

    • Author(s)
      Ogata Masao、Phan Tuan L.、Fukuda Takahiro
    • Journal Title

      American Journal of Transplantation

      Volume: 19 Issue: 1 Pages: 306-307

    • DOI

      10.1111/ajt.15069

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of HHV-6 DNA detection in plasma and whole blood in allogeneic hematopoietic stem cell transplant recipients: frequent false-positive results for active HHV-6 infection using whole blood samples2018

    • Author(s)
      Takano Kuniko、Ogata Masao、Kawano Rie、Satou Takako、Nashimoto Yuko、Shirao Kuniaki
    • Journal Title

      International Journal of Hematology

      Volume: 108 Issue: 5 Pages: 535-542

    • DOI

      10.1007/s12185-018-2498-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Prophylactic Foscarnet on Human Herpesvirus-6 Reactivation and Encephalitis in Cord Blood Transplant Recipients: A Prospective Multicenter Trial with an Historical Control Group2018

    • Author(s)
      Ogata Masao、Takano Kuniko、Moriuchi Yukiyoshi、Kondo Tadakazu、Ueki Toshimitsu、Nakano Nobuaki、Mori Takehiko、Uoshima Nobuhiko、Nagafuji Koji、Yamasaki Satoshi、Shibasaki Yasuhiko、Sakai Rika、Kato Koji、Choi Ilseung、Jo Yumi、Eto Tetsuya、Kako Shinichi、Oshima Kumi、Fukuda Takahiro
    • Journal Title

      Biology of Blood and Marrow Transplantation

      Volume: 印刷中 Issue: 6 Pages: 1264-1273

    • DOI

      10.1016/j.bbmt.2018.02.008

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation2017

    • Author(s)
      Ogata M、Oshima K、Ikebe T、Takano K、Kanamori H、Kondo T、Ueda Y、Mori T、Hashimoto H、Ogawa H、Eto T、Ueki T、Miyamoto T、Ichinohe T、Atsuta Y、Fukuda T
    • Journal Title

      Bone Marrow Transplant

      Volume: 52 Issue: 11 Pages: 1563-1570

    • DOI

      10.1038/bmt.2017.175

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Human herpesvirus-6B encephalitis after allogeneic HSCT: better understanding the clinical impact, diagnosis, and treatment2020

    • Author(s)
      Ogata M
    • Organizer
      第41回日本造血細胞移植学会総会
    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Invited
  • [Presentation] Cognitive and emotional changes are frequent around the time of HHV-6 reactivation in CBT recipients2020

    • Author(s)
      Ogata M, Inagaki M, Nakamura Y, Okada T, Toubai T, Ueda Y, Uoshima N, Ishida H, Ueki T, Kawano R, Takano K, Oshima K, Shinohara A, Seo S, Fukuda T
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 同種臍帯血移植後HHV-6再活性化の認知機能と生活の質に与える影響に関する前向き観察研究2019

    • Author(s)
      緒方正男、植木俊光、大島久美、河野利恵、篠原明仁、瀬尾幸子、高野久仁子、福田隆浩、稲垣正俊
    • Organizer
      平成30年度第2回造血幹細胞移植合同班会議
    • Related Report
      2019 Research-status Report 2018 Research-status Report
  • [Presentation] Development of the Japanese guideline for management of HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation2019

    • Author(s)
      Ogata M, Uchida N, Fukuda T, Miyamoto T
    • Organizer
      The 11th International Conference on HHV-6&7
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] HHV-6 encephalitis in allogeneic hematopoietic stem cell transplantation: How should we manage it?2019

    • Author(s)
      Ogata M
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Comparison of HHV-6 DNA detection in plasma and whole blood among allogeneic HSCT recipients2018

    • Author(s)
      Ogata M, Takano K, Kawano R, Satou T, Nashimoto Y, Shirao K
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Clinical characteristics and outcome of HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation: results from a Japanese nationwide study2017

    • Author(s)
      Ogata M, Oshima K, Ikebe T, Takano K, Kanamori H, Kondo T, Ueda Y, Mori T, Hashimoto H, Ogawa H, Eto T, Ueki T, Miyamoto T, Ichinohe T, Atsuta Y, and Fukuda T
    • Organizer
      The 10th International Conference on HHV-6 & 7
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Foscarnet to prevent HHV-6 encephalitis in cord blood transplant recipients: a multicenter, open-label, single-arm, phase 2 trial2017

    • Author(s)
      Fukuda T, Ogata M
    • Organizer
      The 10th International Conference on HHV-6 & 7
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Foscarnet for the prevention of HHV-6 encephalitis in cord blood transplantation: a multicenter, phase 2 trial2017

    • Author(s)
      Ogata M, Takano K, Moriuchi Y, Kondo T, Ueki T, Nakano N, Mori T, Uoshima N, Jo Y, Tanaka M, Yamasaki S, Choi I, Kato K, Shibasaki Y, Fukuda T
    • Organizer
      第79回日本血液学会学術集会
    • Related Report
      2017 Research-status Report
  • [Book] 造血細胞移植ガイドライン ウイルス感染症の予防と治療 HHV-62018

    • Author(s)
      緒方正男、内田直之、福田隆浩
    • Total Pages
      21
    • Publisher
      日本造血細胞移植学会ガイドライン委員会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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