Research on the risk and prevention of developing esophageal squamous cell carcinoma based on the ALDH2/ADH1B polymorphism and the grade of Lugo-voiding lesions on the background esophageal mucosa.

• Project/Area Number: 17K09093
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kitasato University
• Principal Investigator: Katada Chikatoshi 北里大学, 医学部, 講師 (80327361)
• Co-Investigator(Kenkyū-buntansha): 竹下 達也 和歌山県立医科大学, 医学部, 博士研究員 (20150310) ; 牟礼 佳苗 和歌山県立医科大学, 医学部, 准教授 (90268491)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 食道癌 / アルコール / 予防 / ADH1B / ALDH2 / CYP2A6 / ヨード不染帯 / JEC試験 / 飲酒 / 喫煙

Outline of Final Research Achievements

In patients with esophageal squamous cell carcinoma after endoscopic resection, slow ADH1B was significantly associated with a higher cumulative incidence of metachronous esophageal cancer. ALDH2 polymorphism was not associated with a cumulative incidence of metachronous esophageal cancer. Inactive ALDH2, slow ADH1B and CYP2A6 negative were significantly associated with a higher total number of metachronous esophageal cancer per 100 person-years. In a multivariate analysis, slow ADH1B was a risk factor for the development of metachronous esophageal cancer. In patients with slow ADH1B, the frequency of Grade C Lugol-voiding lesions of the esophagus was significantly higher.

Academic Significance and Societal Importance of the Research Achievements

食道癌内視鏡治療例において、新たに発生する食道癌の総数には、ALDH2/ADH1B/CYP2A6の遺伝子多型と関連していた。累積発生割合はADH1Bが関連しており、多変量解析ではSlow ADH1Bがリスク因子であった。内視鏡下に食道粘膜にヨードを散布することで確認できる多発ヨード不染帯は、食道癌発生の強力なリスク因子であるが、Slow ADH1Bには多発ヨード不染帯が多かった。アルコール代謝関連酵素（ADH1B/ALDH2）の遺伝子多型に基づいた飲酒教育は、食道癌の一次予防に貢献する可能性があり、遺伝子多型からハイリスク者を同定して内視鏡がん検診を行う二次予防につながる可能性もある。

Research Products

• [Journal Article] Effect of chemoradiation on the development of second primary cancers after endoscopic resection of T1 esophageal squamous cell carcinoma. (2022)
  • Author(s): Yoshio T, Minashi K, Mizusawa J, Morita Y, Tajika M, Fujiwara J, Yamamoto Y, Katada C, Hori S, Yano T, Takizawa K, Fukuda H, Muto M.
  • Journal Title: Esophagus Volume: -
  • Peer Reviewed
• [Journal Article] History of endoscopic diagnosis and treatment for esophageal and pharyngeal squamous cell carcinoma. (2022)
  • Author(s): Ishihara R, Katada C.
  • Journal Title: Dig Endosc Volume: in press
  • Peer Reviewed
• [Journal Article] A Field effect of alcohol, cigarette smoking, and their cessation on the development of multiple dysplastic lesions and squamous cell carcinoma: a long-term multicenter cohort study. (2022)
  • Author(s): Manabu M, Katada C, Yokoyama T, Yano T, Oda I, Ezoe Y, Tanabe S, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Ogata T, Katagiri A, Yamanouchi T, Matsuo Y, Kawakubo H, Omori T, Kobayashi N, Shimoda T, Ochiai A, Ishikawa H, Baba K, Amanuma Y, Yokoyama A, Ohashi S, Yokoyama A.
  • Journal Title: Gastro Hep Advances Volume: 1 Pages: 265-276
  • Peer Reviewed / Open Access
• [Journal Article] Current status of diagnostic and therapeutic colonoscopy in Japan: The Japan Endoscopic Database Project. (2022)
  • Author(s): Saito Y, Kodashima S, Matsuda T, Matsuda K, Fujishiro M, Tanaka K, Kobayashi K, Katada C, Horimatsu T, Muto M, Ohtsuka K, Oda I, Kato M, Kida M, Hoteya S, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Kato M, Haruma K, Fujimoto K, Iishi H, Ogata H, Uemura N, Kaminishi M, Tajiri H, Inoue H.
  • Journal Title: Dig Endosc Volume: 34 Pages: 144-152
  • Peer Reviewed
• [Journal Article] Transoral Surgery for Superficial Head and Neck Cancer: National Multi-center Survey in Japan. (2021)
  • Author(s): Katada C, Muto M, Fujii S, Yokoyama T, Yano T, Watanabe A, Iizuka T, Yoshinaga S, Tateya I, Mitani H, Shimizu Y, Takahashi A, Kamijo T, Hanaoka N, Abe M, Shiotani A, Kano K, Asada Y, Matsuhashi T, Umeno H, Okami K, Goda K, Hori S, Ono Y, Terai S, Nagami Y, Sakamoto Y, Ichinoe M, Hayashi R.
  • Journal Title: Cancer Med Volume: 10 Pages: 3848-3861
  • Peer Reviewed / Open Access
• [Journal Article] Predictive significance of promoter DNA methylation of cysteine dioxygenase type 1 (CDO1) in metachronous gastric cancer. (2021)
  • Author(s): Kubota Y, Tanabe S, Azuma M, Horio K, Fujiyama Y, Soeno T, Furue Y, Wada T, Watanabe A, Ishido K, Katada C, Yamashita K, Koizumi W, Kusano C.
  • Journal Title: J Gastic Cancer Volume: 21 Pages: 379-391
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection of cervical esophageal cancer with hypopharyngeal invasion using a curved laryngoscope. (2021)
  • Author(s): Furue Y, Katada C, Kano K, Yoshida T, Yamashita T.
  • Journal Title: Video GIE Volume: 17 Pages: 533-535
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative chemotherapy could modify recurrence patterns through postoperative complications in patients with gastric cancer. (2021)
  • Author(s): Hosoda K, Ushiku H, Katada C, Ishido K, Niihara M, Sakuraya M, Araki I, Washio M, Harada H, Yamashita K, Hiki N.
  • Journal Title: Langenbecks Arch Surg Volume: 406 Pages: 1045-1055
  • Peer Reviewed
• [Journal Article] Usefulness of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma in elderly patients: a single-center retrospective cohort study. (2021)
  • Author(s): Ishido K, Tanabe S, Katada C, Kubota Y, Furue Y, Wada T, Watanabe A, Koizumi W.
  • Journal Title: Jpn J Clin Oncol Volume: 51 Pages: 895-904
  • Peer Reviewed
• [Journal Article] Randomized study of prevention of gastrointestinal toxicities by nutritional support using an amino acid-rich elemental diet during chemotherapy in patients with esophageal cancer (KDOG 1101). (2021)
  • Author(s): Katada C, Fukazawa S, Sugawara M, Sakamoto Y, Takahashi K, Takahashi A, Watanabe A, Wada T, Ishido K, Furue Y, Harada H, Hosoda K, Yamashita K, Hiki N, Sato T, Ichikawa T, Shichiri M, Tanabe S, Koizumi W.
  • Journal Title: Esophagus Volume: 18 Pages: 296-305
  • NAID: 40022523273
  • Peer Reviewed
• [Journal Article] Evaluation of the usefulness of upper gastrointestinal endoscopy and the Valsamouth by an otolaryngologist in patients with hypopharyngeal cancer. (2021)
  • Author(s): Hosono H, Katada C, Kano K, Kimura A, Tsutsumi S, Miyamoto S, Ichinoe M, Furue Y, Tanabe S, Koizumi W, Yamashita T.
  • Journal Title: Auris Nasus Larynx Volume: 48 Pages: 265-273
  • Peer Reviewed
• [Journal Article] Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions. (2020)
  • Author(s): Katada C, Yokoyama T, Yano T, Oda I, Shimizu Y, Takemura K, Koike T, Takizawa K, Hirao M, Okada H, Nakayama N, Kubota Y, Matsuo Y, Kawakubo H, Ishikawa H, Yokoyama A, Muto M.
  • Journal Title: Dis Esophagus Volume: 33 Issue: 9
  • DOI: 10.1093/dote/doz110
  • Peer Reviewed
• [Journal Article] Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma. (2020)
  • Author(s): Katada C, Yokoyama T, Yano T, Oda I, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Kubota Y, Yamanouchi T, Tsuda T, Omori T, Kobayashi N, Suzuki H, Tanabe S, Hori K, Nakayama N, Kawakubo H, Kakushima N, Matsuo Y, Ishikawa H, Yokoyama A, Muto M.
  • Journal Title: Esophagus Volume: 17 Issue: 2 Pages: 149-158
  • DOI: 10.1007/s10388-019-00685-w
  • NAID: 40022193329
  • Peer Reviewed / Open Access
• [Journal Article] Long-term outcome of endoscopic mucosal resection for intramucosal esophageal squamous cell cancer: a secondary analysis of the Japan Esophageal Cohort study. (2020)
  • Author(s): Oda I, Shimizu Y, Yoshio T, Katada C, Yokoyama T, Yano T, Suzuki H, Abiko S, Takemura K, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Katagiri A, Yamanouchi T, Matsuo Y, Kawakubo H, Kobayashi N, Shimoda S, Ochiai A, Ishikawa H, Yokoyama A, Muto M.
  • Journal Title: Endoscopy Volume: 52 Issue: 11 Pages: 967-975
  • DOI: 10.1055/a-1185-9329
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of lymph-node metastasis and lymphatic invasion of superficial pharyngeal cancer on narrow band imaging with magnifying endoscopy. (2020)
  • Author(s): Katada C, Okamoto T, Ichinoe M, Sakamoto Y, Kano K, Hosono H, Miyamoto S, Tanabe S, Koizumi W, Yamashita T.
  • Journal Title: Auris Nasus Larynx Volume: 47 Issue: 1 Pages: 128-134
  • DOI: 10.1016/j.anl.2019.04.008
  • Peer Reviewed
• [Journal Article] Effectiveness of planned surveillance for detecting second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma. (2020)
  • Author(s): Shinozaki T, Katada C, Shiga K, Asakage T, Yokoyama T, Yano T, Oda I, Shimizu Y, Takemura K, Ishikawa H, Yokoyama A, Muto M.
  • Journal Title: Jpn J Clin Oncol Volume: 50 Issue: 10 Pages: 1162-1167
  • DOI: 10.1093/jjco/hyaa087
  • Peer Reviewed
• [Journal Article] The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer. (2020)
  • Author(s): Yokoyama A, Katada C, Yokoyama T, Takizawa K, Yano T, Oda I, Shimizu Y, Nakanishi H, Koike T, Hirao M, Okada H, Yoshii T, Katagiri A, Yamanouchi T, Matsuo Y, Kawakubo H, Kobayashi N, Ishikawa H, Muto M.
  • Journal Title: Carcinogenesis Volume: 41 Issue: 8 Pages: 1049-1056
  • DOI: 10.1093/carcin/bgaa022
  • Peer Reviewed / Open Access
• [Journal Article] Retrospective Assessment of the Diagnostic Accuracy of the Depth of Invasion by Narrow Band Imaging Magnifying Endoscopy in Patients with Superficial Esophageal Squamous Cell Carcinoma. (2019)
  • Author(s): Katada C, Tanabe S, Wada T, Ishido K, Yano T, Furue Y, Kondo Y, Kawanishi N, Yamane S, Watanabe A, Azuma M, Koizumi W.
  • Journal Title: J Gastrointest Cancer Volume: 50 Issue: 2 Pages: 292-297
  • DOI: 10.1007/s12029-018-0075-6
  • Peer Reviewed
• [Journal Article] Efficacy of Endoscopic Resection and Selective Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma. (2019)
  • Author(s): Minashi K, Nihei K, Mizusawa J, Takizawa K, Yano T, Ezoe Y, Tsuchida T, Ono H, Iizuka T, Hanaoka N, Oda I, Morita Y, Tajika M, Fujiwara J, Yamamoto Y, Katada C, Hori S, Doyama H, Oyama T, Nebiki H, Amagai K, Kubota Y, Nishimura K, Kobayashi N, Suzuki T, Hirasawa K, Takeuchi T, Fukuda H, Muto M.
  • Journal Title: Gastroenterology Volume: 157 Issue: 2 Pages: 382-390
  • DOI: 10.1053/j.gastro.2019.04.017
  • NAID: 120006817594
  • Peer Reviewed
• [Journal Article] Impact of the Charlson Comorbidity Index on the treatment strategy and survival in elderly patients after non-curative endoscopic submucosal dissection for esophageal squamous cell carcinoma: a multicenter retrospective study. (2019)
  • Author(s): Nakajo K, Abe S, Oda I, Ishihara R, Tanaka M, Yoshio T, Katada C, Yano T.
  • Journal Title: J Gastroenterol Volume: 54 Issue: 10 Pages: 871-880
  • DOI: 10.1007/s00535-019-01583-9
  • Peer Reviewed
• [Journal Article] Comprehensive Exploration to Identify Predictive DNA Markers of ΔNp63/SOX2 in Drug Resistance in Human Esophageal Squamous Cell Carcinoma. (2019)
  • Author(s): Ooizumi Y, Kojima K, Igarashi K, Tanaka Y, Harada H, Yokota K, Kaida T, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Washio M, Ushiku H, Katoh H, Kosaka Y, Mieno H, Hosoda K, Watanabe M, Katada C, Hiki N, Yamashita K.
  • Journal Title: Ann Surg Oncol Volume: 26 Issue: 13 Pages: 4814-4825
  • DOI: 10.1245/s10434-019-07795-w
  • Peer Reviewed
• [Journal Article] A retrospective study of treatment for curative synchronous double primary cancers of the head and neck and the esophagus. (2018)
  • Author(s): Okamoto T, Katada C, Komori S, Yamashita K, Miyamoto S, Kano K, Seino Y, Hosono H, Matsuba H, Moriya H, Sugawara M, Azuma M, Ishiyama H, Tanabe S, Hayakawa K, Koizumi W, Okamoto M, Yamashita T
  • Journal Title: Auris Nasus Larynx Volume: 45 Issue: 5 Pages: 1053-1060
  • DOI: 10.1016/j.anl.2017.12.005
  • Peer Reviewed
• [Journal Article] Effectiveness and safety of endoscopic aspiration mucosectomy and endoscopic submucosal dissection in patients with superficial esophageal squamous-cell carcinoma. (2018)
  • Author(s): Furue Y, Katada C, Tanabe S, Ishido K, Kondo Y, Kubota Y, Kawanishi N, Yamane S, Watanabe A, Moriya H, Yamashita K, Wada T, Yano T, Azuma M, Koizumi W.
  • Journal Title: Surg Endosc Volume: 印刷中 Issue: 5 Pages: 1433-1440
  • DOI: 10.1007/s00464-018-6418-3
  • Peer Reviewed
• [Journal Article] Current Status of Esophageal Endoscopy Including the Evaluation of Smoking and Alcohol Consumption in Japan: An Analysis Based on the Japan Endoscopy Database. (2018)
  • Author(s): Katada C, Horimatsu T, Muto M, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Kato M, Kida M, Kobayashi K, Hoteya S, Kodashima S, Matsuda T, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H.
  • Journal Title: Esophagus Volume: 印刷中 Issue: 2 Pages: 174-179
  • DOI: 10.1007/s10388-018-0650-8
  • NAID: 40021862192
  • Peer Reviewed
• [Journal Article] Usefulness of narrow band imaging with magnifying endoscopy for the differential diagnosis of cancerous and noncancerous laryngeal lesions. (2018)
  • Author(s): Hosono H, Katada C, Okamoto T, Ichinoe M, Sakamoto Y, Matsuba H, Kano K, Ishido K, Tanabe S, Koizumi W, Yamashita T.
  • Journal Title: Head Neck Volume: 印刷中 Issue: 8 Pages: 2555-2560
  • DOI: 10.1002/hed.25734
  • Peer Reviewed
• [Journal Article] Validation study of a health risk appraisal model and endoscopic screening for early esophageal cancer in men in specialized hospitals. (2017)
  • Author(s): Kondo Y, Katada C, Tanabe S, Wada T, Ishido K, Yano Y, Kawanishi N, Furue Y, Yamane S, Suzuki M, Watanabe A, Azuma M, Moriya H, Yamashita K, Koizumi W, Yokoyama A.
  • Journal Title: Esophagus Volume: 14 Pages: 235-240
  • NAID: 40021255154
  • Peer Reviewed
• [Journal Article] Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. (2017)
  • Author(s): Yokoyama A, Katada C, Yokoyama T, Yano T, Kaneko K, Oda I, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Konishi K, Yamanouchi T, Tsuda T, Omori T, Kobayashi N, Suzuki H, Tanabe S, Hori K, Nakayama N, Kawakubo H, Ishikawa H, Muto M.
  • Journal Title: PLoS One Volume: 12 Issue: 4 Pages: e0175182-e0175182
  • DOI: 10.1371/journal.pone.0175182
  • NAID: 120006313618
  • Peer Reviewed
• [Journal Article] Endoscopic diagnosis and treatment of superficial pharyngeal cancer. (2017)
  • Author(s): Katada C, Okamoto T, Kano K.
  • Journal Title: Dig Endosc Volume: 29 Issue: 7 Pages: 824-824
  • DOI: 10.1111/den.12948
  • Peer Reviewed
• [Presentation] 頭頸部表在癌の内視鏡診断 - AI内視鏡診断構築の試み -. (2021)
  • Author(s): 堅田親利, 古江康明, 田邊聡, 加納孝一, 細野浩, 山下拓, 一戸昌明, 吉田功, 村雲芳樹, 三枝信.
  • Organizer: 第110回日本病理学会総会
  • Invited
• [Presentation] A phase II study of chemoseleciton with docetaxel, cisplatin and 5-fuluorouracil as a strategy for organ preservation in patients with resectable esophageal cancer. (2021)
  • Author(s): Katada C, Hara H, Fujii H, Nakajima TE, Ando T, Nomura M, Kojima T, Yamashita K, Yokoyama T, Sakamoto Y, Sasaki H, Inoue Y, Kawakami S, Ishikawa H, Hosokawa Y, Hamamoto Y, Muto M, Tanara M, Koizumi W.
  • Organizer: ASCO2021 Annual Meeting
  • Int'l Joint Research
• [Presentation] Endoscopic diagnosis for superficial head and neck cancer. (2021)
  • Author(s): Katada C, Furue Y, Wada T, Tanabe S, Kano K, Hosono H, Yamashita T, Ichinoe M, Yoshida T, Murakumo Y, Saegusa M.
  • Organizer: 第59回日本癌治療学会学術集会
  • Invited
• [Presentation] 本邦における喫煙・飲酒状況の評価を含めた食道内視鏡検査の現状 Japan Endoscopy Database (JED)による検討-. (2020)
  • Author(s): 堅田親利, 堀松高博, 武藤学
  • Organizer: 第99回日本消化器内視鏡学会総会
• [Presentation] 頭頸部表在癌の診断と治療. (2020)
  • Author(s): 堅田親利, 加納孝一, 細野浩, 山下拓
  • Organizer: 第44回日本頭頸部癌学会
• [Presentation] 食道表在扁平上皮癌内視鏡切除後に発生する異時性頭頸部食道癌とAlcohol Use Disorders Identification Test (AUDIT)の関連. (2020)
  • Author(s): 堅田親利, 横山顕, 武藤学
  • Organizer: JDDW2020
• [Presentation] 食道癌内視鏡切除例における異時性癌のリスクと禁酒禁煙の関連 -JEC試験長期追跡. (2020)
  • Author(s): 堅田親利, 横山徹爾, 矢野友規, 小田一郎, 清水勇一, 土山寿志, 小池智幸, 石川秀樹, 横山顕, 武藤学
  • Organizer: 第74回日本食道学会学術集会
• [Presentation] 食道癌の発癌メカニズムと予防に関するコホート研究 -JEC試験の最新知見-. (2020)
  • Author(s): 堅田親利
  • Organizer: がん予防学術大会2020
  • Invited
• [Presentation] アルコール関連発癌に基づいた咽頭食道表在癌診療の新展開 (2020)
  • Author(s): 堅田親利
  • Organizer: 第39回アルコール医学生物学研究会学術集会
  • Invited
• [Presentation] Drinking alcohol, smoking, multiple dysplastic lesions and the risk of field cancerization of squamous cell carcinoma in the esophagus and head and neck region. (2019)
  • Author(s): Katada C, Yokoyama T, Yano T, Oda I, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Ishikawa H, Yokoyama A, Muto M.
  • Organizer: ESMO 2019
  • Int'l Joint Research
• [Presentation] 咽頭食道表在癌診療における新展開 (2019)
  • Author(s): 堅田親利
  • Organizer: 第13回 日本消化管学会教育集会
  • Invited
• [Presentation] 頭頸部表在癌に対する経口的手術の今後の展開 (2019)
  • Author(s): 堅田親利, 武藤学, 林隆一.
  • Organizer: JDDW 2019
• [Presentation] 内視鏡による咽頭スクリーニング (2019)
  • Author(s): 堅田親利
  • Organizer: 第73回日本食道学会学術集会教育セミナー
  • Invited
• [Presentation] Prediction of lymph node metastasis and lymphatic invasion of superficial pharyngeal cancer on NBI magnifying endoscopy. (2018)
  • Author(s): Chikatoshi Katada, Tabito Okamoto, Masaaki Ichinoe
  • Organizer: 第95回日本消化器内視鏡学会総会
• [Presentation] Safety and Effectiveness of Transoral Surgery for Superficial Head and Neck Cancer: The National Registration Survey of Superficial Head and Neck Cancer. (2018)
  • Author(s): Chikatoshi Katada, Satoshi Fujii, Tetsuji Yokoyama et al.
  • Organizer: ASCO2018
  • Int'l Joint Research
• [Presentation] 頭頸部表在癌の内視鏡診断と治療 (2018)
  • Author(s): 堅田親利
  • Organizer: 第42回日本頭頸部癌学会
  • Invited
• [Presentation] 食道・咽頭表在癌に対する内視鏡的粘膜下層剥離術（ESD） (2018)
  • Author(s): 堅田親利
  • Organizer: 第70回気管食道科学会
• [Presentation] Risk factors for the development of dysplastic squamous epithelium in the esophagus. (2017)
  • Author(s): Katada C, Yokoyama T, Yano T, Oda I, Shimizu Y, Tanabe S, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Konishi K, Yamanouchi T, Tsuda T, Omori T, Kobayashi N, Ishikawa H, Yokoyama A, Muto M
  • Organizer: 25th uegweek
  • Int'l Joint Research
• [Presentation] 早期食道癌に対する内視鏡切除に発生する異時性他臓器重複癌の検討 (2017)
  • Author(s): 堅田親利、横山徹爾、矢野友規、小田一郎、清水勇一、土山寿志、小池智幸、滝沢耕平、平尾素宏、武藤学
  • Organizer: 第71回日本食道学会学術集会
• [Presentation] Japan Esophageal Cohort (JEC) study -手法と今後の課題- (2017)
  • Author(s): 武藤学、堅田親利
  • Organizer: 第93回日本消化器内視鏡学会総会
• [Remarks] JEC試験 (UMIN000001676) 登録例の頬粘膜組織を用いた遺伝子多型解析に関する付随研究
  • URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000039642