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Comprehensvie analysis of association between diabetes and pancreatic cancer

Research Project

Project/Area Number 17K09095
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionAichi Medical University

Principal Investigator

Lin Yingsong  愛知医科大学, 医学部, 教授 (50340302)

Co-Investigator(Kenkyū-buntansha) 中杤 昌弘  名古屋大学, 医学系研究科(保健), 准教授 (10559983)
伊藤 秀美  愛知県がんセンター(研究所), がん情報・対策研究分野, 分野長 (90393123)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵がん / 糖尿病 / メンデルランダム化 / リスクモデル / 遺伝子多型 / Mendelian randomization法 / Polyriskスコア / ヘモグロビンA1C / 膵癌 / GP2 / 罹病期間 / オッズ比 / がん
Outline of Final Research Achievements

In a multi-institute case-control study of pancreatic cancer, individuals with a history of diabetes had approximately 3-fold increased risk for pancreatic cancer compared with those without. In Mendelian randomiaztion analyses, genetically determined hemoglobin A1c levels were shown to be signicantly associated with pancreatic cancer risk. We also found that diabetes and pancreatic cancer share genetic susceptibility factors when comparing the SNPs that were identified in the genome-wide association studies (GWASs) for both diabetes and pancreatc cancer. Clarification of the relatioship between diabetes and pancreatic cancer contributes to pancreatic cancer etiology and prevention.

Academic Significance and Societal Importance of the Research Achievements

日本では糖尿病と膵がんの関連を多角的に検討した研究が非常に少ない。本研究では、まず糖尿病歴と膵がん罹患リスクの関連を明らかにした。次に、メンデルランダム化(MR)解析を実施し、遺伝要因によって規定されているヘモグロビンA1c(血糖コントロール指標)は、膵がんリスクとの有意な関連が認められた。インスリン抵抗性や分泌不全を基盤とした2型糖尿病が日本で急増している中で、本研究成果は、糖尿病と膵がんの関連をより明確にし、膵がんの予防につながるものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (16 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (12 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 10 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study2021

    • Author(s)
      Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, et al
    • Journal Title

      Journal of Epidemiology

      Volume: 31 Issue: 3 Pages: 172-179

    • DOI

      10.2188/jea.JE20190296

    • NAID

      130007995132

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2021-03-05
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum Pepsinogen Values in Japanese Junior High School Students With Reference to <i>Helicobacter Pylori</i> Infection2020

    • Author(s)
      Okuda M, Lin Y, Mabe K, Kato M, Osaki T, Miyamoto R, Okumura A, Kamiya S, Kikuchi S.
    • Journal Title

      Journal of Epidemiology

      Volume: 30 Issue: 1 Pages: 30-36

    • DOI

      10.2188/jea.JE20180119

    • NAID

      130007782484

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2020-01-05
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of type 2 diabetes loci in 433,540 East Asian individuals2020

    • Author(s)
      Spracklen, C.N., Horikoshi, M., Kim, Y.J., Lin K, Bragg F, Nakatochi M, et al.
    • Journal Title

      Nature

      Volume: 582 Issue: 7811 Pages: 240

    • DOI

      10.1038/s41586-020-2263-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer2020

    • Author(s)
      Lin Y, Nakatochi Y, Hosono Y, Ito H, Kamatani Y, et al.
    • Journal Title

      Nature Communications

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Smoking and Pancreatic Cancer Incidence: A Pooled Analysis of 10 Population-Based Cohort Studies in Japan2019

    • Author(s)
      Koyanagi Yuriko N.、Ito Hidemi、Matsuo Keitaro、Sugawara Yumi、Hidaka Akihisa、Sawada Norie、Wada Keiko、Nagata Chisato、Tamakoshi Akiko、Lin Yingsong、Takeuchi Taro、Kitamura Yuri、Utada Mai、Sadakane Atsuko、Mizoue Tetsuya、Naito Mariko、Tanaka Keitaro、Shimazu Taichi、Tsugane Shoichiro、Inoue Manami
    • Journal Title

      Cancer Epidemiology Biomarkers & Prevention

      Volume: 28 Issue: 8 Pages: 1370-1378

    • DOI

      10.1158/1055-9965.epi-18-1327

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coffee consumption and mortality in Japanese men and women: A pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium).2019

    • Author(s)
      Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Tamakoshi A, Sado J, Kitamura Y, Sugawara Y, Tsuji I, Nagata C, Sadakane A, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M
    • Journal Title

      Prev. Med.

      Volume: 123 Pages: 270-277

    • DOI

      10.1016/j.ypmed.2019.04.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals2019

    • Author(s)
      Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, et al.
    • Journal Title

      Commun Biol.

      Volume: 2 Issue: 1 Pages: 115-115

    • DOI

      10.1038/s42003-019-0339-0

    • NAID

      120006937615

    • URL

      https://pure.teikyo.jp/en/publications/d2b1a87f-6b8d-4bb5-a753-843e5cd6647d

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population2019

    • Author(s)
      Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, et al.
    • Journal Title

      Sleep

      Volume: 印刷中 Issue: 6

    • DOI

      10.1093/sleep/zsz046

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction model for pancreatic cancer risk in the general Japanese population.2018

    • Author(s)
      Nakatochi M, Lin Y, Ito H, Hara K, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Sasahira N, Morimoto M, Kobayashi S, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Wang C, Nishiyama T, Kawaguchi T, Takahashi M, Matsuda F, Kikuchi S, Matsuo K
    • Journal Title

      PLoS One

      Volume: 13(9) Issue: 9 Pages: e0203386-e0203386

    • DOI

      10.1371/journal.pone.0203386

    • NAID

      120006822483

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.212018

    • Author(s)
      Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, et al.
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 12 Pages: 4015-4024

    • DOI

      10.1111/cas.13815

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation2017

    • Author(s)
      Campa D, Pastore M, Capurso G, Hackert T, Di Leo M, Izbicki JR, Khaw KT, Gioffreda D, Kupcinskas J, Pasquali C, Macinga P, Kaaks R, Stigliano S, Peeters PH, Key TJ, Talar-Wojnarowska R, Vodicka P, Hidemi Ito, Keitaro Matsuo et al.
    • Journal Title

      International Journal of Cancer

      Volume: 142 Issue: 2 Pages: 290-296

    • DOI

      10.1002/ijc.31047

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 糖尿病と膵癌2017

    • Author(s)
      江川直人
    • Journal Title

      お茶の水医学雑誌

      Volume: 65 Pages: 173-184

    • Related Report
      2017 Research-status Report
  • [Presentation] Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population2019

    • Author(s)
      Yingsong Lin, Masahiro Nakatochi, Hidemi Ito, Yoichiro Kamatani, Hiromi Sakamoto, Hiroshi Ishii, et al.
    • Organizer
      the American Association for Cancer Research Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction model for pancreatic cancer risk in the general Japanese population2018

    • Author(s)
      Yingsong Lin*, Masahiro Nakatochi, Hidemi Ito, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Naoki Sasahira, Makoto Ueno, Naoto Egawa, Sawako Kuruma, Haruhisa Nakao, Fumihiko Matsuda, Shogo Kikuchi, Keitaro Matsuo
    • Organizer
      AACR Special Conference, Pancreatic Cancer: Advances in Science and Clinical Care
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 一般日本人集団における膵がん発症予測モデルの構築2017

    • Author(s)
      中杤 昌弘、林 櫻松、伊藤 秀美、木下 文恵、小林 由美子、石井 浩、笹平 直樹、上野 誠、江川 直人、来間 佐和子、中尾 春壽、松田 文彦、菊地 正悟、松尾 恵太朗
    • Organizer
      日本人類遺伝学会第62回大会
    • Related Report
      2017 Research-status Report
  • [Remarks] 日本膵がん研究コンソーシアム (JaPAN)

    • URL

      http://www.aichi-med-u.c.jp/JaPAN

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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