Comprehensvie analysis of association between diabetes and pancreatic cancer
Project/Area Number |
17K09095
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Aichi Medical University |
Principal Investigator |
Lin Yingsong 愛知医科大学, 医学部, 教授 (50340302)
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Co-Investigator(Kenkyū-buntansha) |
中杤 昌弘 名古屋大学, 医学系研究科(保健), 准教授 (10559983)
伊藤 秀美 愛知県がんセンター(研究所), がん情報・対策研究分野, 分野長 (90393123)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 膵がん / 糖尿病 / メンデルランダム化 / リスクモデル / 遺伝子多型 / Mendelian randomization法 / Polyriskスコア / ヘモグロビンA1C / 膵癌 / GP2 / 罹病期間 / オッズ比 / がん |
Outline of Final Research Achievements |
In a multi-institute case-control study of pancreatic cancer, individuals with a history of diabetes had approximately 3-fold increased risk for pancreatic cancer compared with those without. In Mendelian randomiaztion analyses, genetically determined hemoglobin A1c levels were shown to be signicantly associated with pancreatic cancer risk. We also found that diabetes and pancreatic cancer share genetic susceptibility factors when comparing the SNPs that were identified in the genome-wide association studies (GWASs) for both diabetes and pancreatc cancer. Clarification of the relatioship between diabetes and pancreatic cancer contributes to pancreatic cancer etiology and prevention.
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Academic Significance and Societal Importance of the Research Achievements |
日本では糖尿病と膵がんの関連を多角的に検討した研究が非常に少ない。本研究では、まず糖尿病歴と膵がん罹患リスクの関連を明らかにした。次に、メンデルランダム化(MR)解析を実施し、遺伝要因によって規定されているヘモグロビンA1c(血糖コントロール指標)は、膵がんリスクとの有意な関連が認められた。インスリン抵抗性や分泌不全を基盤とした2型糖尿病が日本で急増している中で、本研究成果は、糖尿病と膵がんの関連をより明確にし、膵がんの予防につながるものである。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Identification of type 2 diabetes loci in 433,540 East Asian individuals.2020
Author(s)
Spracklen, C.N., Horikoshi, M., Kim, Y.J., Lin K, Bragg F, Nakatochi M, et al.
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Journal Title
Nature
Volume: 印刷中
Issue: 7811
Pages: 240-245
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Coffee consumption and mortality in Japanese men and women: A pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium).2019
Author(s)
Abe SK, Saito E, Sawada N, Tsugane S, Ito H, Lin Y, Tamakoshi A, Sado J, Kitamura Y, Sugawara Y, Tsuji I, Nagata C, Sadakane A, Shimazu T, Mizoue T, Matsuo K, Naito M, Tanaka K, Inoue M
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Journal Title
Prev. Med.
Volume: 123
Pages: 270-277
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.2019
Author(s)
Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, et al.
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Journal Title
Commun Biol.
Volume: 2
Issue: 1
Pages: 115-115
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prediction model for pancreatic cancer risk in the general Japanese population.2018
Author(s)
Nakatochi M, Lin Y, Ito H, Hara K, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Sasahira N, Morimoto M, Kobayashi S, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Wang C, Nishiyama T, Kawaguchi T, Takahashi M, Matsuda F, Kikuchi S, Matsuo K
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Journal Title
PLoS One
Volume: 13(9)
Issue: 9
Pages: e0203386-e0203386
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation2017
Author(s)
Campa D, Pastore M, Capurso G, Hackert T, Di Leo M, Izbicki JR, Khaw KT, Gioffreda D, Kupcinskas J, Pasquali C, Macinga P, Kaaks R, Stigliano S, Peeters PH, Key TJ, Talar-Wojnarowska R, Vodicka P, Hidemi Ito, Keitaro Matsuo et al.
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Journal Title
International Journal of Cancer
Volume: 142
Issue: 2
Pages: 290-296
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Prediction model for pancreatic cancer risk in the general Japanese population2018
Author(s)
Yingsong Lin*, Masahiro Nakatochi, Hidemi Ito, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Naoki Sasahira, Makoto Ueno, Naoto Egawa, Sawako Kuruma, Haruhisa Nakao, Fumihiko Matsuda, Shogo Kikuchi, Keitaro Matsuo
Organizer
AACR Special Conference, Pancreatic Cancer: Advances in Science and Clinical Care
Related Report
Int'l Joint Research
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